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    OPRM1 opioid receptor mu 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574141, updated on 17-Aug-2024

    Summary

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    Official Symbol
    OPRM1provided by VGNC
    Official Full Name
    opioid receptor mu 1provided by VGNC
    Primary source
    VGNC:VGNC:83440
    See related
    Ensembl:ENSMMUG00000022691
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See OPRM1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (60275359..60397879)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 4 NC_027896.1 (111985568..112105176, complement)

    Chromosome 4 - NC_041757.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC106998071 Neighboring gene interaction protein for cytohesin exchange factors 1 Neighboring gene CNKSR family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OPRM1 genotype interacts with serotonin system dysfunction to predict alcohol-heightened aggression in primates. Driscoll CA, et al. Addict Biol, 2017 Nov. PMID 27484010, Free PMC Article
    2. OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors in rhesus macaques. Schwandt ML, et al. Psychoneuroendocrinology, 2011 Oct. PMID 21459516, Free PMC Article
    3. Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates. Barr CS, et al. Proc Natl Acad Sci U S A, 2008 Apr 1. PMID 18378897, Free PMC Article
    4. Chronic prenatal cocaine treatment down-regulates mu-opioid receptor mRNA expression in the brain of fetal Rhesus Macaque. Chai L, et al. Neurosci Lett, 1999 Feb 12. PMID 10081923
    5. Roles of μ-opioid receptors and nociceptin/orphanin FQ peptide receptors in buprenorphine-induced physiological responses in primates. Cremeans CM, et al. J Pharmacol Exp Ther, 2012 Oct. PMID 22743574, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A nonsynonymous SNP in the first exon of the OPRM1 gene (OPRM1 A118G) encodes the ligand-binding domain the receptor and which has been associated with increased alcohol-induced stimulation and euphoria.
      Title: OPRM1 genotype interacts with serotonin system dysfunction to predict alcohol-heightened aggression in primates.
    2. Coactivation of mu opioid receptors with nociceptin receptors produces synergistic antinociception.
      Title: Roles of μ-opioid receptors and nociceptin/orphanin FQ peptide receptors in buprenorphine-induced physiological responses in primates.
    3. Thisstudy adds to the growing literature showing that variation in the mu-opioid receptor gene OPRM1 is associated with social attachment and rejection.
      Title: Mu-opioid receptor (OPRM1) variation, oxytocin levels and maternal attachment in free-ranging rhesus macaques Macaca mulatta.
    4. OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors.
      Title: OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors in rhesus macaques.
    5. findings suggest a role for OPRM1 variation in the expression of attachment behavior, especially as a function of separation from the caregiver
      Title: Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables G-protein beta-subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables beta-endorphin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables morphine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables neuropeptide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled opioid receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mu-type opioid receptor
    Names
    M-OR-1
    MOR-1
    mu opioid receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032824.1 → NP_001027996.1  mu-type opioid receptor

      See identical proteins and their annotated locations for NP_001027996.1

      Status: PROVISIONAL

      Source sequence(s)
      AF286024
      UniProtKB/Swiss-Prot
      Q9MYW9
      UniProtKB/TrEMBL
      A0A1D5Q767
      Related
      ENSMMUP00000043883.2, ENSMMUT00000074867.2
      Conserved Domains (2) summary
      pfam00001
      Location:87 → 338
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:79 → 285
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041757.1 Reference Mmul_10 Primary Assembly

      Range
      60275359..60397879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015137070.2 → XP_014992556.1  mu-type opioid receptor isoform X2

      Conserved Domains (1) summary
      cd15090
      Location:1 → 249
      7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_015137065.2 → XP_014992551.2  mu-type opioid receptor isoform X1

      UniProtKB/TrEMBL
      A0A1D5Q767
      Conserved Domains (1) summary
      cd15090
      Location:71 → 349
      7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_015137071.2 → XP_014992557.2  mu-type opioid receptor isoform X3

      Conserved Domains (2) summary
      cd14964
      Location:73 → 97
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:71 → 98
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. XM_015137067.2 → XP_014992553.1  mu-type opioid receptor isoform X2

      Conserved Domains (1) summary
      cd15090
      Location:1 → 249
      7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors

    5. XM_015137068.2 → XP_014992554.1  mu-type opioid receptor isoform X2

      Conserved Domains (1) summary
      cd15090
      Location:1 → 249
      7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9MYW9.2 GenPept UniProtKB/Swiss-Prot:Q9MYW9

    Gene LinkOut

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