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    LYN LYN proto-oncogene, Src family tyrosine kinase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 698553, updated on 17-Aug-2024

    Summary

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    Official Symbol
    LYNprovided by VGNC
    Official Full Name
    LYN proto-oncogene, Src family tyrosine kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:74464
    Locus tag
    EGK_18962
    See related
    Ensembl:ENSMMUG00000014149
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See LYN in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 8 NC_041761.1 (56506690..56644873)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 8 NC_027900.1 (53835524..53974122)

    Chromosome 8 - NC_041761.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114680252 Neighboring gene transmembrane protein 68 Neighboring gene trimethylguanosine synthase 1 Neighboring gene small nucleolar RNA SNORA1 Neighboring gene small nucleolar RNA U54 Neighboring gene nucleophosmin pseudogene Neighboring gene ribosomal protein S20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extrinsic component of cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein kinase Lyn
    Names
    v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
    XP_001087049.2
    XP_015000871.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041761.1 Reference Mmul_10 Primary Assembly

      Range
      56506690..56644873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001087049.4 → XP_001087049.2  tyrosine-protein kinase Lyn isoform X1

      See identical proteins and their annotated locations for XP_001087049.2

      UniProtKB/TrEMBL
      A0A663D5D8, A0A8J8YHP5, F7BV42, G7MZD6, H9F8Q0
      Related
      ENSMMUP00000071141.1, ENSMMUT00000088863.1
      Conserved Domains (3) summary
      cd10364
      Location:125 → 225
      SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
      cd12004
      Location:67 → 122
      SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
      cd05072
      Location:239 → 510
      PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

    2. XM_015145385.2 → XP_015000871.1  tyrosine-protein kinase Lyn isoform X2

      UniProtKB/TrEMBL
      H9F8Q0
      Conserved Domains (3) summary
      cd10364
      Location:104 → 204
      SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
      cd12004
      Location:46 → 101
      SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
      cd05072
      Location:218 → 489
      PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn
    Nucleotide Protein
    Heading Accession and Version

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