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    INSRR insulin receptor related receptor [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 718670, updated on 17-Aug-2024

    Summary

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    Official Symbol
    INSRRprovided by VGNC
    Official Full Name
    insulin receptor related receptorprovided by VGNC
    Primary source
    VGNC:VGNC:106390
    See related
    Ensembl:ENSMMUG00000055304
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See INSRR in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (94106585..94125864)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (131480213..131499454, complement)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene platelet endothelial aggregation receptor 1 Neighboring gene neurotrophic receptor tyrosine kinase 1 Neighboring gene uncharacterized LOC114670326 Neighboring gene SH2 domain containing 2A Neighboring gene proline rich mitotic checkpoint control factor Neighboring gene heparin binding growth factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables insulin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables insulin receptor substrate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphatidylinositol 3-kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of insulin receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    insulin receptor-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      94106585..94125864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015112355.2 → XP_014967841.1  insulin receptor-related protein isoform X4

      UniProtKB/TrEMBL
      A0A5F7ZFV3, G7ME13
      Related
      ENSMMUP00000064503.1, ENSMMUT00000081282.1
      Conserved Domains (6) summary
      cd05032
      Location:972 → 1248
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      cd00063
      Location:819 → 908
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00064
      Location:228 → 275
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:173 → 326
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:346 → 460
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:979 → 1246
      Pkinase_Tyr; Protein tyrosine kinase

    2. XM_015112344.2 → XP_014967830.1  insulin receptor-related protein isoform X1

      UniProtKB/TrEMBL
      G7ME13
      Conserved Domains (6) summary
      cd05032
      Location:1035 → 1285
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      cd00063
      Location:819 → 908
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00064
      Location:228 → 275
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:173 → 326
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:346 → 460
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:1042 → 1286
      Pkinase_Tyr; Protein tyrosine kinase

    3. XM_015112346.2 → XP_014967832.1  insulin receptor-related protein isoform X2

      UniProtKB/TrEMBL
      G7ME13
      Conserved Domains (6) summary
      cd05032
      Location:1035 → 1311
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      cd00063
      Location:819 → 908
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00064
      Location:228 → 275
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:173 → 326
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:346 → 460
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:1042 → 1309
      Pkinase_Tyr; Protein tyrosine kinase

    4. XM_015112351.2 → XP_014967837.1  insulin receptor-related protein isoform X3

      UniProtKB/TrEMBL
      G7ME13
      Conserved Domains (6) summary
      cd05032
      Location:972 → 1222
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      cd00063
      Location:819 → 908
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00064
      Location:228 → 275
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:173 → 326
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:346 → 460
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:979 → 1223
      Pkinase_Tyr; Protein tyrosine kinase

    5. XM_028827494.1 → XP_028683327.1  insulin receptor-related protein isoform X5

      UniProtKB/TrEMBL
      G7ME13
      Conserved Domains (4) summary
      cd00063
      Location:819 → 908
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00757
      Location:173 → 326
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:346 → 459
      Recep_L_domain; Receptor L domain
      cl21453
      Location:1035 → 1239
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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