HTR1A 5-hydroxytryptamine receptor 1A [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: HTR1Aprovided by VGNC
Official Full Name: 5-hydroxytryptamine receptor 1Aprovided by VGNC
Primary source: VGNC:VGNC:73536
Locus tag: EGK_16528
See related: Ensembl:ENSMMUG00000001789
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as: 5-HT1A
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	6	NC_041759.1 (62470874..62472748, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	6	NC_027898.1 (62106389..62108263, complement)

Chromosome 6 - NC_041759.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased levels of 5-HT1A receptor binding were seen in the raphe nuclei following chronic ethanol self-administration.
Title: The effects of chronic alcohol self-administration on serotonin-1A receptor binding in nonhuman primates.
Cimbi-36 is the first agonist radioligand suitable for examination of 5-HT2A receptors in the cortical regions and of 5-HT2C receptors in the choroid plexus of the primate brain.
Title: Characterization of [(11)C]Cimbi-36 as an agonist PET radioligand for the 5-HT(2A) and 5-HT(2C) receptors in the nonhuman primate brain.
Significantly lower 5-HT1A binding is found in s-carrier subjects (5-HTTLPR genotype) in both cortical brain regions and the raphe nuclei.
Title: Serotonin transporter genotype affects serotonin 5-HT1A binding in primates.
5-HT1A receptor levels increase during development in the female brain from pre-to peripuberty.
Title: The relation of developmental changes in brain serotonin transporter (5HTT) and 5HT1A receptor binding to emotional behavior in female rhesus monkeys: effects of social status and 5HTT genotype.
5HT1A receptor may lose sensitivity to the suppressive effect of estradiol after 5 months, whereas the 5HT2C receptor increases, however, addition of progesterone in the EP5 regimen maintains the regulatory effects
Title: Differential effects of ovarian steroids and raloxifene on serotonin 1A and 2C receptor protein expression in macaques.

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General gene information

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Markers

NoName (e-PCR)
- UniSTS:481605

RH70818 (e-PCR)
- UniSTS:27760

HTR1A (e-PCR)
- UniSTS:479890

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables G protein-coupled serotonin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of behavior	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of hormone secretion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 1A

Names: serotonin receptor type 1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.