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    TIAM2 TIAM Rac1 associated GEF 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 701688, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TIAM2provided by VGNC
    Official Full Name
    TIAM Rac1 associated GEF 2provided by VGNC
    Primary source
    VGNC:VGNC:81887
    See related
    Ensembl:ENSMMUG00000011169
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See TIAM2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (61288695..61561905)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 4 NC_027896.1 (110823171..110994586, complement)

    Chromosome 4 - NC_041757.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114677386 Neighboring gene SR-related CTD associated factor 8 Neighboring gene U6 spliceosomal RNA Neighboring gene transcription factor B1, mitochondrial Neighboring gene claudin 20 Neighboring gene NADPH oxidase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    T-lymphoma invasion and metastasis-inducing protein 2
    Names
    T cell lymphoma invasion and metastasis 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041757.1 Reference Mmul_10 Primary Assembly

      Range
      61288695..61561905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015137091.2 → XP_014992577.2  T-lymphoma invasion and metastasis-inducing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A5K1UFG6, G7MQ27
      Conserved Domains (5) summary
      smart00325
      Location:1103 → 1292
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:888 → 973
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:505 → 631
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1294 → 1466
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      cl28922
      Location:811 → 881
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. XM_028847275.1 → XP_028703108.1  T-lymphoma invasion and metastasis-inducing protein 2 isoform X2

      UniProtKB/TrEMBL
      F6VAK2, G7MQ27
      Related
      ENSMMUP00000014621.3, ENSMMUT00000015612.4
      Conserved Domains (4) summary
      smart00325
      Location:1049 → 1238
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:834 → 919
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:505 → 631
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1240 → 1412
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

    3. XM_015137092.2 → XP_014992578.2  T-lymphoma invasion and metastasis-inducing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A5K1UFG6, G7MQ27
      Related
      ENSMMUP00000033271.3, ENSMMUT00000040200.3
      Conserved Domains (5) summary
      smart00325
      Location:1103 → 1292
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:888 → 973
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:505 → 631
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:1294 → 1466
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      cl28922
      Location:811 → 881
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    4. XM_015137094.2 → XP_014992580.1  T-lymphoma invasion and metastasis-inducing protein 2 isoform X3

      Conserved Domains (2) summary
      cd01255
      Location:219 → 391
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam00621
      Location:28 → 217
      RhoGEF; RhoGEF domain
    Nucleotide Protein
    Heading Accession and Version

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