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    HFE homeostatic iron regulator [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 696129, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HFEprovided by VGNC
    Official Full Name
    homeostatic iron regulatorprovided by VGNC
    Primary source
    VGNC:VGNC:73371
    Locus tag
    EGK_14545
    See related
    Ensembl:ENSMMUG00000023733
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See HFE in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (143893579..143902368, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 4 NC_027896.1 (26673153..26682003)

    Chromosome 4 - NC_041757.1Genomic Context describing neighboring genes Neighboring gene H2B clustered histone 4 Neighboring gene histone H3.1-like Neighboring gene H1.6 linker histone, cluster member Neighboring gene H1.2 linker histone, cluster member Neighboring gene H2A clustered histone 5, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables transferrin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of T cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to iron ion starvation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hereditary hemochromatosis protein
    Names
    HFE alpha 3 domain
    hemochromatosis

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001260576.2 → NP_001247505.1  hereditary hemochromatosis protein precursor

      See identical proteins and their annotated locations for NP_001247505.1

      Status: PROVISIONAL

      Source sequence(s)
      JU334244
      UniProtKB/TrEMBL
      A0A8J8YEH6, F7HAR1, G7MR22, H9FTP0
      Related
      ENSMMUP00000034329.2, ENSMMUT00000041296.3
      Conserved Domains (2) summary
      cd07698
      Location:206 → 298
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:27 → 199
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041757.1 Reference Mmul_10 Primary Assembly

      Range
      143893579..143902368 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028846640.1 → XP_028702473.1  hereditary hemochromatosis protein isoform X2

      Conserved Domains (1) summary
      cd07698
      Location:27 → 118
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

    2. XM_015135625.2 → XP_014991111.2  hereditary hemochromatosis protein isoform X1

      UniProtKB/TrEMBL
      H9FTP1
      Conserved Domains (2) summary
      cd07698
      Location:114 → 206
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:27 → 113
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    Nucleotide Protein
    Heading Accession and Version

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