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    POLQ DNA polymerase theta [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 713828, updated on 17-Aug-2024

    Summary

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    Official Symbol
    POLQprovided by VGNC
    Official Full Name
    DNA polymerase thetaprovided by VGNC
    Primary source
    VGNC:VGNC:76210
    See related
    Ensembl:ENSMMUG00000007973
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See POLQ in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (154779718..154885253)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (42604783..42710316, complement)

    Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene arginine-fifty homeobox Neighboring gene syntaxin binding protein 5L Neighboring gene nucleosome assembly protein 1-like 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in double-strand break repair via alternative nonhomologous end joining IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA polymerase theta
    Names
    polymerase (DNA directed), theta
    XP_014985456.2
    XP_014985457.2
    XP_014985458.2
    XP_028700428.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041755.1 Reference Mmul_10 Primary Assembly

      Range
      154779718..154885253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015129970.2 → XP_014985456.2  DNA polymerase theta isoform X1

      UniProtKB/TrEMBL
      A0A1D5QQG1
      Related
      ENSMMUP00000050288.2, ENSMMUT00000054300.2
      Conserved Domains (4) summary
      cd08638
      Location:2093 → 2587
      DNA_pol_A_theta; DNA polymerase theta is a low-fidelity family A enzyme implicated in translesion synthesis and in somatic hypermutation
      COG1204
      Location:82 → 844
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      cd18026
      Location:82 → 295
      DEXHc_POLQ-like; DEXH-box helicase domain of DNA polymerase theta
      cl10012
      Location:1902 → 2087
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

    2. XM_015129971.2 → XP_014985457.2  DNA polymerase theta isoform X2

      UniProtKB/TrEMBL
      A0A1D5QQG1
      Conserved Domains (4) summary
      cd08638
      Location:2093 → 2588
      DNA_pol_A_theta; DNA polymerase theta is a low-fidelity family A enzyme implicated in translesion synthesis and in somatic hypermutation
      COG1204
      Location:82 → 844
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      cd18026
      Location:82 → 295
      DEXHc_POLQ-like; DEXH-box helicase domain of DNA polymerase theta
      cl10012
      Location:1902 → 2087
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

    3. XM_028844595.1 → XP_028700428.1  DNA polymerase theta isoform X3

      UniProtKB/TrEMBL
      A0A1D5QQG1
      Conserved Domains (3) summary
      cd08638
      Location:1916 → 2411
      DNA_pol_A_theta; DNA polymerase theta is a low-fidelity family A enzyme implicated in translesion synthesis and in somatic hypermutation
      COG1204
      Location:14 → 667
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      cl10012
      Location:1725 → 1910
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

    4. XM_015129972.2 → XP_014985458.2  DNA polymerase theta isoform X3

      UniProtKB/TrEMBL
      A0A1D5QQG1
      Conserved Domains (3) summary
      cd08638
      Location:1916 → 2411
      DNA_pol_A_theta; DNA polymerase theta is a low-fidelity family A enzyme implicated in translesion synthesis and in somatic hypermutation
      COG1204
      Location:14 → 667
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      cl10012
      Location:1725 → 1910
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    Nucleotide Protein
    Heading Accession and Version

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