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    NTRK1 neurotrophic receptor tyrosine kinase 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 719670, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NTRK1provided by VGNC
    Official Full Name
    neurotrophic receptor tyrosine kinase 1provided by VGNC
    Primary source
    VGNC:VGNC:75540
    See related
    Ensembl:ENSMMUG00000012424
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See NTRK1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (94083877..94106399, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (131501290..131522507)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 71 Neighboring gene platelet endothelial aggregation receptor 1 Neighboring gene uncharacterized LOC114670326 Neighboring gene insulin receptor related receptor Neighboring gene SH2 domain containing 2A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables neurotrophin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables neurotrophin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to nerve growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nerve growth factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    high affinity nerve growth factor receptor
    XP_001114243.4
    XP_028683330.1
    XP_028683332.1
    XP_028683336.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      94083877..94106399 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001114243.4 → XP_001114243.4  high affinity nerve growth factor receptor isoform X3

      UniProtKB/TrEMBL
      F7DJ84
      Related
      ENSMMUP00000016315.4, ENSMMUT00000017421.4
      Conserved Domains (6) summary
      cd04971
      Location:325 → 405
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:222 → 308
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd05092
      Location:530 → 809
      PTKc_TrkA; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A
      sd00031
      Location:94 → 118
      LRR_1; leucine-rich repeat [structural motif]
      pfam16920
      Location:177 → 218
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      pfam13855
      Location:118 → 176
      LRR_8; Leucine rich repeat

    2. XM_028827503.1 → XP_028683336.1  high affinity nerve growth factor receptor isoform X4

      UniProtKB/TrEMBL
      F7DJ75, F7DJ84
      Related
      ENSMMUP00000016316.4, ENSMMUT00000017422.4
      Conserved Domains (6) summary
      cd04971
      Location:325 → 405
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:222 → 308
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd05092
      Location:524 → 803
      PTKc_TrkA; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A
      sd00031
      Location:94 → 118
      LRR_1; leucine-rich repeat [structural motif]
      pfam16920
      Location:177 → 218
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      pfam13855
      Location:118 → 176
      LRR_8; Leucine rich repeat

    3. XM_028827499.1 → XP_028683332.1  high affinity nerve growth factor receptor isoform X2

      UniProtKB/TrEMBL
      F7DJ84
      Conserved Domains (6) summary
      cd04971
      Location:299 → 379
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:196 → 282
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd05092
      Location:498 → 777
      PTKc_TrkA; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A
      sd00031
      Location:93 → 116
      LRR_1; leucine-rich repeat [structural motif]
      pfam16920
      Location:151 → 192
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      pfam13855
      Location:92 → 150
      LRR_8; Leucine rich repeat

    4. XM_028827497.1 → XP_028683330.1  high affinity nerve growth factor receptor isoform X1

      UniProtKB/TrEMBL
      F7DJ84
      Conserved Domains (6) summary
      cd04971
      Location:299 → 379
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:196 → 282
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd05092
      Location:504 → 783
      PTKc_TrkA; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A
      sd00031
      Location:93 → 116
      LRR_1; leucine-rich repeat [structural motif]
      pfam16920
      Location:151 → 192
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      pfam13855
      Location:92 → 150
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version

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