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    TLE3 TLE family member 3, transcriptional corepressor [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 698046, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TLE3provided by VGNC
    Official Full Name
    TLE family member 3, transcriptional corepressorprovided by VGNC
    Primary source
    VGNC:VGNC:78366
    See related
    Ensembl:ENSMMUG00000014023
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See TLE3 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (46764911..46815768, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (47032898..47084402, complement)

    Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene gem-associated protein 8 pseudogene Neighboring gene uncharacterized LOC114679260 Neighboring gene U6 spliceosomal RNA Neighboring gene 40S ribosomal protein SA-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transducin-like enhancer protein 3
    Names
    transducin like enhancer of split 3
    transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041760.1 Reference Mmul_10 Primary Assembly

      Range
      46764911..46815768 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015142581.2 → XP_014998067.1  transducin-like enhancer protein 3 isoform X15

      UniProtKB/TrEMBL
      F7AVT5
      Conserved Domains (4) summary
      COG2319
      Location:476 → 761
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:475 → 760
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 132
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:480 → 519
      7WD40; WD40 repeat [structural motif]

    2. XM_015142573.2 → XP_014998059.1  transducin-like enhancer protein 3 isoform X7

      UniProtKB/TrEMBL
      F7AVT5
      Conserved Domains (4) summary
      COG2319
      Location:477 → 769
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:483 → 768
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 132
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:488 → 527
      7WD40; WD40 repeat [structural motif]

    3. XM_015142582.2 → XP_014998068.1  transducin-like enhancer protein 3 isoform X16

      UniProtKB/TrEMBL
      F7AVT5, H9ZCZ1
      Conserved Domains (3) summary
      cd00200
      Location:467 → 752
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:472 → 511
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    4. XM_015142579.2 → XP_014998065.1  transducin-like enhancer protein 3 isoform X13

      UniProtKB/TrEMBL
      F7AVT5, H9ZCZ2
      Conserved Domains (3) summary
      cd00200
      Location:472 → 757
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:477 → 516
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    5. XM_015142578.2 → XP_014998064.1  transducin-like enhancer protein 3 isoform X12

      UniProtKB/TrEMBL
      F7AVT5
      Conserved Domains (4) summary
      COG2319
      Location:470 → 762
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:476 → 761
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:481 → 520
      7WD40; WD40 repeat [structural motif]

    6. XM_015142575.2 → XP_014998061.1  transducin-like enhancer protein 3 isoform X9

      UniProtKB/TrEMBL
      F7AVT5, H9EN36
      Related
      ENSMMUP00000043241.2, ENSMMUT00000060441.2
      Conserved Domains (4) summary
      COG2319
      Location:475 → 767
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:481 → 766
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:486 → 525
      7WD40; WD40 repeat [structural motif]

    7. XM_015142569.2 → XP_014998055.1  transducin-like enhancer protein 3 isoform X3

      UniProtKB/TrEMBL
      F7AVT5
      Conserved Domains (4) summary
      COG2319
      Location:487 → 779
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:493 → 778
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 142
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:498 → 537
      7WD40; WD40 repeat [structural motif]

    8. XM_015142577.2 → XP_014998063.1  transducin-like enhancer protein 3 isoform X11

      UniProtKB/TrEMBL
      F7AVT5
      Conserved Domains (3) summary
      cd00200
      Location:477 → 762
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:482 → 521
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    9. XM_015142574.2 → XP_014998060.1  transducin-like enhancer protein 3 isoform X8

      UniProtKB/TrEMBL
      F7AVT5
      Conserved Domains (3) summary
      cd00200
      Location:482 → 767
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:487 → 526
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    10. XM_015142571.2 → XP_014998057.1  transducin-like enhancer protein 3 isoform X5

      UniProtKB/TrEMBL
      F7AVT5
      Conserved Domains (4) summary
      COG2319
      Location:480 → 772
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:486 → 771
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:491 → 530
      7WD40; WD40 repeat [structural motif]

    11. XM_015142570.2 → XP_014998056.1  transducin-like enhancer protein 3 isoform X4

      UniProtKB/TrEMBL
      F7AVT5
      Conserved Domains (4) summary
      COG2319
      Location:485 → 777
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:491 → 776
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:496 → 535
      7WD40; WD40 repeat [structural motif]

    12. XM_015142568.2 → XP_014998054.1  transducin-like enhancer protein 3 isoform X2

      UniProtKB/TrEMBL
      F7AVT5
      Conserved Domains (4) summary
      COG2319
      Location:488 → 780
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:494 → 779
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:499 → 538
      7WD40; WD40 repeat [structural motif]

    13. XM_015142576.2 → XP_014998062.1  transducin-like enhancer protein 3 isoform X10

      UniProtKB/TrEMBL
      F7AVT5
      Conserved Domains (4) summary
      COG2319
      Location:473 → 765
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:479 → 764
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:484 → 523
      7WD40; WD40 repeat [structural motif]

    14. XM_015142572.2 → XP_014998058.1  transducin-like enhancer protein 3 isoform X6

      UniProtKB/TrEMBL
      A0A1D5R774, F7AVT5, H9ZCZ0
      Related
      ENSMMUP00000056162.2, ENSMMUT00000067151.2
      Conserved Domains (4) summary
      COG2319
      Location:478 → 770
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:484 → 769
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:489 → 528
      7WD40; WD40 repeat [structural motif]

    15. XM_015142567.2 → XP_014998053.1  transducin-like enhancer protein 3 isoform X1

      UniProtKB/TrEMBL
      F7AVT5
      Conserved Domains (4) summary
      COG2319
      Location:423 → 708
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:422 → 707
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 76
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:427 → 466
      7WD40; WD40 repeat [structural motif]

    16. XM_015142580.2 → XP_014998066.1  transducin-like enhancer protein 3 isoform X14

      Conserved Domains (4) summary
      COG2319
      Location:485 → 617
      WD40; WD40 repeat [General function prediction only]
      pfam03920
      Location:1 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:494 → 533
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:490 → 617
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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