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    SHMT1 serine hydroxymethyltransferase 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 701186, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SHMT1provided by VGNC
    Official Full Name
    serine hydroxymethyltransferase 1provided by VGNC
    Primary source
    VGNC:VGNC:103864
    See related
    Ensembl:ENSMMUG00000013535
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See SHMT1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 16 NC_041769.1 (18175976..18213528, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 16 NC_027908.1 (18503125..18540753, complement)

    Chromosome 16 - NC_041769.1Genomic Context describing neighboring genes Neighboring gene DNA topoisomerase III alpha Neighboring gene SMCR8-C9orf72 complex subunit Neighboring gene uncharacterized LOC106993915 Neighboring gene uncharacterized LOC106993916 Neighboring gene coactosin-like protein pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cobalt ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables glycine hydroxymethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables mRNA 5'-UTR binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables mRNA regulatory element binding translation repressor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-serine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in folic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in glycine biosynthetic process from serine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in purine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine hydroxymethyltransferase, cytosolic
    NP_001244360.1
    XP_014974168.1
    XP_014974169.1
    XP_014974170.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001257431.1 → NP_001244360.1  serine hydroxymethyltransferase, cytosolic

      See identical proteins and their annotated locations for NP_001244360.1

      Status: PROVISIONAL

      Source sequence(s)
      JU335936
      UniProtKB/TrEMBL
      F6WIE8, F7FV99, G7NJ32
      Conserved Domains (2) summary
      PLN03226
      Location:24 → 480
      PLN03226; serine hydroxymethyltransferase; Provisional
      pfam00464
      Location:26 → 425
      SHMT; Serine hydroxymethyltransferase

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041769.1 Reference Mmul_10 Primary Assembly

      Range
      18175976..18213528 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015118682.2 → XP_014974168.1  serine hydroxymethyltransferase, cytosolic isoform X1

      UniProtKB/TrEMBL
      F6WIE8, F7FV99, G7NJ32
      Related
      ENSMMUP00000017801.4, ENSMMUT00000019005.4
      Conserved Domains (2) summary
      PLN03226
      Location:24 → 480
      PLN03226; serine hydroxymethyltransferase; Provisional
      pfam00464
      Location:26 → 425
      SHMT; Serine hydroxymethyltransferase

    2. XM_015118684.2 → XP_014974170.1  serine hydroxymethyltransferase, cytosolic isoform X1

      UniProtKB/TrEMBL
      F6WIE8, F7FV99, G7NJ32
      Conserved Domains (2) summary
      PLN03226
      Location:24 → 480
      PLN03226; serine hydroxymethyltransferase; Provisional
      pfam00464
      Location:26 → 425
      SHMT; Serine hydroxymethyltransferase

    3. XM_015118683.2 → XP_014974169.1  serine hydroxymethyltransferase, cytosolic isoform X1

      UniProtKB/TrEMBL
      F6WIE8, F7FV99, G7NJ32
      Conserved Domains (2) summary
      PLN03226
      Location:24 → 480
      PLN03226; serine hydroxymethyltransferase; Provisional
      pfam00464
      Location:26 → 425
      SHMT; Serine hydroxymethyltransferase
    Nucleotide Protein
    Heading Accession and Version

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    Molecular Biology Databases
    Research Materials