TPH2 tryptophan hydroxylase 2 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: TPH2provided by VGNC
Official Full Name: tryptophan hydroxylase 2provided by VGNC
Primary source: VGNC:VGNC:79270
See related: Ensembl:ENSMMUG00000007730
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	11	NC_041764.1 (71510031..71600964)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	11	NC_027903.1 (70772942..70863894)

Chromosome 11 - NC_041764.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TPH2 5'- and 3'-regulatory polymorphisms are differentially associated with hypothalamo-pituitary-adrenal axis function and self-injurious behavior in rhesus monkeys
Title: TPH2 5'- and 3'-regulatory polymorphisms are differentially associated with HPA axis function and self-injurious behavior in rhesus monkeys.
The present study supports the hypothesis that rearing experience and rhTPH2 A2051C interact to influence central 5-HT metabolism, HPA axis function, and aggressive behaviors
Title: The effect of rearing experience and TPH2 genotype on HPA axis function and aggression in rhesus monkeys: a retrospective analysis.
functional significance of two nonsynonymous single nucleotide polymorphisms (SNPs) (C74A and G223A) in rhesus monkey TPH2
Title: Rhesus monkey tryptophan hydroxylase-2 coding region haplotypes affect mRNA stability.
Study identified 17 single nucleotide polymorphisms; 3'-UTR polymorphisms were significantly associated with HPA axis activity, especially 2051A>C, which was strikingly correlated with plasma cortisol level in the morning only.
Title: Tryptophan hydroxylase-2 gene polymorphisms in rhesus monkeys: association with hypothalamic-pituitary-adrenal axis function and in vitro gene expression.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables iron ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables tryptophan 5-monooxygenase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in aromatic amino acid metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in serotonin biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in neuron projection	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tryptophan 5-hydroxylase 2

Names: neuronal tryptophan hydroxylase; tryptophan 5-monooxygenase 2

NP_001035035.1

EC 1.14.16.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039946.1 → NP_001035035.1 tryptophan 5-hydroxylase 2

See identical proteins and their annotated locations for NP_001035035.1

Status: PROVISIONAL

Source sequence(s)

DQ360113

UniProtKB/Swiss-Prot

Q2HZ26

UniProtKB/TrEMBL

G7N7N9

Related

ENSMMUP00000010151.3, ENSMMUT00000010821.3

Conserved Domains (2) summary

pfam00351
Location:152 → 482

Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase

cl09141
Location:64 → 137

ACT; ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme