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    PTPRZ1 protein tyrosine phosphatase receptor type Z1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574174, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PTPRZ1provided by VGNC
    Official Full Name
    protein tyrosine phosphatase receptor type Z1provided by VGNC
    Primary source
    VGNC:VGNC:76625
    See related
    Ensembl:ENSMMUG00000012418
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PTPRZ1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (148281089..148473558)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (147844844..148040629)

    Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene FAM3 metabolism regulating signaling molecule C Neighboring gene 60S ribosomal protein L18 pseudogene Neighboring gene U7 small nuclear RNA Neighboring gene tetratricopeptide repeat protein 14-like Neighboring gene aminoadipate-semialdehyde synthase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidyl-tyrosine dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase zeta
    Names
    receptor-protein tyrosine phosphatase beta
    NP_001265311.1
    NP_001265330.1
    XP_014990266.2
    XP_014990267.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278382.1 → NP_001265311.1  receptor-type tyrosine-protein phosphatase zeta isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JU335709, JV477015, JV515406, JV553208, JV553209
      UniProtKB/TrEMBL
      F7DJJ9
      Related
      ENSMMUP00000016302.4, ENSMMUT00000017408.4
      Conserved Domains (5) summary
      smart00194
      Location:1720 → 1995
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:1756 → 1995
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd03122
      Location:45 → 298
      alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
      pfam00041
      Location:313 → 401
      fn3; Fibronectin type III domain
      pfam07777
      Location:684 → 763
      MFMR; G-box binding protein MFMR

    2. NM_001278401.1 → NP_001265330.1  receptor-type tyrosine-protein phosphatase zeta isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame alternate exon in the 3' coding region compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter than isoform 1.
      Source sequence(s)
      JU335709, JV477015, JV515406, JV553208, JV553209
      UniProtKB/TrEMBL
      A0A5F8AB20
      Related
      ENSMMUP00000075133.1, ENSMMUT00000108821.1
      Conserved Domains (5) summary
      smart00194
      Location:1720 → 1988
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:1749 → 1988
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd03122
      Location:45 → 298
      alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
      pfam00041
      Location:313 → 401
      fn3; Fibronectin type III domain
      pfam07777
      Location:684 → 763
      MFMR; G-box binding protein MFMR

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041756.1 Reference Mmul_10 Primary Assembly

      Range
      148281089..148473558
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015134780.2 → XP_014990266.2  receptor-type tyrosine-protein phosphatase zeta isoform X1

      Conserved Domains (4) summary
      cd03122
      Location:45 → 298
      alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
      pfam00041
      Location:313 → 395
      fn3; Fibronectin type III domain
      cd17669
      Location:1217 → 1420
      R-PTP-Z-2; catalytic domain of receptor-type tyrosine-protein phosphatase Z, repeat 2
      cl28904
      Location:857 → 1134
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    2. XM_015134781.2 → XP_014990267.2  receptor-type tyrosine-protein phosphatase zeta isoform X2

      Conserved Domains (4) summary
      cd03122
      Location:45 → 298
      alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
      pfam00041
      Location:313 → 395
      fn3; Fibronectin type III domain
      cd17669
      Location:1210 → 1413
      R-PTP-Z-2; catalytic domain of receptor-type tyrosine-protein phosphatase Z, repeat 2
      cl28904
      Location:857 → 1127
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    Nucleotide Protein
    Heading Accession and Version

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