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    ZSWIM4 zinc finger SWIM-type containing 4 [ Homo sapiens (human) ]

    Gene ID: 65249, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZSWIM4provided by HGNC
    Official Full Name
    zinc finger SWIM-type containing 4provided by HGNC
    Primary source
    HGNC:HGNC:25704
    See related
    Ensembl:ENSG00000132003 MIM:620539; AllianceGenome:HGNC:25704
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in esophagus (RPKM 2.3), lung (RPKM 2.0) and 25 other tissues See more
    Orthologs
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    Genomic context

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    See ZSWIM4 in Genome Data Viewer
    Location:
    19p13.13-p13.12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (13795443..13832254)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (13921625..13958384)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (13906257..13943068)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10208 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:13876533-13877162 Neighboring gene methylthioribose-1-phosphate isomerase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14135 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:13885277-13885806 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:13885807-13886335 Neighboring gene chromosome 19 open reading frame 53 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:13896673-13897634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14136 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10209 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10210 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14137 Neighboring gene uncharacterized LOC107985334 Neighboring gene MPRA-validated peak3376 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:13928069-13928736 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:13928737-13929405 Neighboring gene RNA, 7SL, cytoplasmic 619, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:13929406-13930073 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:13936598-13937294 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14140 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10211 Neighboring gene miR-23a/27a/24-2 cluster host gene Neighboring gene microRNA 24-2 Neighboring gene microRNA 27a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ZSWIM4 inhibition improves chemosensitivity in epithelial ovarian cancer cells by suppressing intracellular glycine biosynthesis. Gong K, et al. J Transl Med, 2024 Feb 21. PMID 38383406, Free PMC Article
    2. SWIM domain protein ZSWIM4 is required for JAK2 inhibition resistance in breast cancer. Gong K, et al. Life Sci, 2021 Aug 15. PMID 34102191
    3. Colonic transcriptional response to 1α,25(OH)(2) vitamin D(3) in African- and European-Americans. Alleyne D, et al. J Steroid Biochem Mol Biol, 2017 Apr. PMID 28163244, Free PMC Article
    4. Characterization of long cDNA clones from human adult spleen. Hattori A, et al. DNA Res, 2000 Dec 31. PMID 11214971
    5. ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection. Hüttenhain R, et al. Cell Host Microbe, 2019 Jul 10. PMID 31253590, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZSWIM4 inhibition improves chemosensitivity in epithelial ovarian cancer cells by suppressing intracellular glycine biosynthesis.
      Title: ZSWIM4 inhibition improves chemosensitivity in epithelial ovarian cancer cells by suppressing intracellular glycine biosynthesis.
    2. SWIM domain protein ZSWIM4 is required for JAK2 inhibition resistance in breast cancer.
      Title: SWIM domain protein ZSWIM4 is required for JAK2 inhibition resistance in breast cancer.
    3. there are inter-ethnic differences for uridine phosphorylase 1 (UPP1) and zinc finger-SWIM containing 4 (ZSWIM4) in response to 1alpha,25(OH)2D3
      Title: Colonic transcriptional response to 1α,25(OH)(2) vitamin D(3) in African- and European-Americans.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of zinc finger, SWIM-type containing 4 (ZSWIM4) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger SWIM domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001367834.3 → NP_001354763.1  zinc finger SWIM domain-containing protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC020916
      Consensus CDS
      CCDS92534.1
      UniProtKB/TrEMBL
      A0AAG2TUE6, K7ERJ6
      Related
      ENSP00000468285.2, ENST00000590508.6

    2. NM_023072.3 → NP_075560.2  zinc finger SWIM domain-containing protein 4 isoform 1

      See identical proteins and their annotated locations for NP_075560.2

      Status: VALIDATED

      Source sequence(s)
      AC020916, AK022283, AK024452, BG764264
      Consensus CDS
      CCDS32924.1
      UniProtKB/Swiss-Prot
      Q9H7M6
      Related
      ENSP00000254323.2, ENST00000254323.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      13795443..13832254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027153.2 → XP_016882642.1  zinc finger SWIM domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0AAG2TUE6

    2. XM_047439236.1 → XP_047295192.1  zinc finger SWIM domain-containing protein 4 isoform X6

    3. XM_017027155.2 → XP_016882644.1  zinc finger SWIM domain-containing protein 4 isoform X3

    4. XM_047439235.1 → XP_047295191.1  zinc finger SWIM domain-containing protein 4 isoform X4

      UniProtKB/TrEMBL
      A0AAG2TUE6

    5. XM_017027154.2 → XP_016882643.1  zinc finger SWIM domain-containing protein 4 isoform X2

    6. XM_017027156.2 → XP_016882645.1  zinc finger SWIM domain-containing protein 4 isoform X8

      UniProtKB/TrEMBL
      A0AAG2TUE6

    7. XM_047439237.1 → XP_047295193.1  zinc finger SWIM domain-containing protein 4 isoform X7

      UniProtKB/TrEMBL
      A0AAG2TUE6

    8. XM_017027157.2 → XP_016882646.1  zinc finger SWIM domain-containing protein 4 isoform X9

    9. XM_024451657.2 → XP_024307425.1  zinc finger SWIM domain-containing protein 4 isoform X5

      UniProtKB/TrEMBL
      A0AAG2TUE6

    RNA

    1. XR_007066949.1 RNA Sequence

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160022.1 Reference GRCh38.p14 PATCHES

      Range
      7284..44095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332708.1 → XP_054188683.1  zinc finger SWIM domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0AAG2TUE6

    2. XM_054332713.1 → XP_054188688.1  zinc finger SWIM domain-containing protein 4 isoform X6

    3. XM_054332710.1 → XP_054188685.1  zinc finger SWIM domain-containing protein 4 isoform X3

    4. XM_054332711.1 → XP_054188686.1  zinc finger SWIM domain-containing protein 4 isoform X4

      UniProtKB/TrEMBL
      A0AAG2TUE6

    5. XM_054332709.1 → XP_054188684.1  zinc finger SWIM domain-containing protein 4 isoform X2

    6. XM_054332715.1 → XP_054188690.1  zinc finger SWIM domain-containing protein 4 isoform X8

      UniProtKB/TrEMBL
      A0AAG2TUE6

    7. XM_054332714.1 → XP_054188689.1  zinc finger SWIM domain-containing protein 4 isoform X7

      UniProtKB/TrEMBL
      A0AAG2TUE6

    8. XM_054332716.1 → XP_054188691.1  zinc finger SWIM domain-containing protein 4 isoform X9

    9. XM_054332712.1 → XP_054188687.1  zinc finger SWIM domain-containing protein 4 isoform X5

      UniProtKB/TrEMBL
      A0AAG2TUE6

    RNA

    1. XR_008485786.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      13921625..13958384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321793.1 → XP_054177768.1  zinc finger SWIM domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0AAG2TUE6

    2. XM_054321798.1 → XP_054177773.1  zinc finger SWIM domain-containing protein 4 isoform X6

    3. XM_054321795.1 → XP_054177770.1  zinc finger SWIM domain-containing protein 4 isoform X3

    4. XM_054321796.1 → XP_054177771.1  zinc finger SWIM domain-containing protein 4 isoform X4

      UniProtKB/TrEMBL
      A0AAG2TUE6

    5. XM_054321794.1 → XP_054177769.1  zinc finger SWIM domain-containing protein 4 isoform X2

    6. XM_054321799.1 → XP_054177774.1  zinc finger SWIM domain-containing protein 4 isoform X9

    7. XM_054321797.1 → XP_054177772.1  zinc finger SWIM domain-containing protein 4 isoform X5

      UniProtKB/TrEMBL
      A0AAG2TUE6

    RNA

    1. XR_008485178.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H7M6.3 GenPept UniProtKB/Swiss-Prot:Q9H7M6

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