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    CORO1B coronin 1B [ Homo sapiens (human) ]

    Gene ID: 57175, updated on 10-Dec-2024

    Summary

    Official Symbol
    CORO1Bprovided by HGNC
    Official Full Name
    coronin 1Bprovided by HGNC
    Primary source
    HGNC:HGNC:2253
    See related
    Ensembl:ENSG00000172725 MIM:609849; AllianceGenome:HGNC:2253
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CORONIN-2
    Summary
    Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility (Cai et al., 2005 [PubMed 16027158]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in prostate (RPKM 38.7), spleen (RPKM 34.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CORO1B in Genome Data Viewer
    Location:
    11q13.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (67435510..67443809, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (67429626..67437925, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67202981..67211280, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67183887-67184722 Neighboring gene carnosine synthase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3631 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3632 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5093 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67195675-67196442 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67196443-67197210 Neighboring gene ribosomal protein S6 kinase B2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67201247-67202008 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67203533-67204294 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67204572-67205104 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67205105-67205637 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67205638-67206170 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67206171-67206702 Neighboring gene protein tyrosine phosphatase receptor type C associated protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5098 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5099 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67209163-67210002 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:67210843-67211682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5101 Neighboring gene G protein-coupled receptor 152 Neighboring gene calcium binding protein 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5103 Neighboring gene transmembrane protein 134 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:67236334-67236958

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • DKFZp762I166

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization PubMed 
    involved_in actin filament branching PubMed 
    involved_in actin filament bundle assembly PubMed 
    involved_in actin filament organization  
    involved_in cell migration  
    involved_in cell migration PubMed 
    involved_in cellular response to platelet-derived growth factor stimulus PubMed 
    involved_in endothelial cell chemotaxis PubMed 
    involved_in endothelial cell chemotaxis PubMed 
    involved_in negative regulation of Arp2/3 complex-mediated actin nucleation PubMed 
    involved_in negative regulation of smooth muscle cell chemotaxis PubMed 
    involved_in positive regulation of lamellipodium morphogenesis PubMed 
    involved_in protein localization to cell leading edge PubMed 
    involved_in regulation of Arp2/3 complex-mediated actin nucleation PubMed 
    involved_in ruffle organization PubMed 
    involved_in wound healing PubMed 

    General protein information

    Preferred Names
    coronin-1B
    Names
    coronin, actin binding protein, 1B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001018070.3 → NP_001018080.1  coronin-1B

      See identical proteins and their annotated locations for NP_001018080.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AP003419, BC006449, DA061767
      Consensus CDS
      CCDS8164.1
      UniProtKB/Swiss-Prot
      B2RD45, Q9BR76
      Related
      ENSP00000377471.1, ENST00000393893.5
      Conserved Domains (2) summary
      sd00039
      Location:38 → 80
      7WD40; WD40 repeat [structural motif]
      cl25676
      Location:10 → 485
      WD40_4; Type of WD40 repeat
    2. NM_020441.3 → NP_065174.1  coronin-1B

      See identical proteins and their annotated locations for NP_065174.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AP003419, BC006449
      Consensus CDS
      CCDS8164.1
      UniProtKB/Swiss-Prot
      B2RD45, Q9BR76
      Related
      ENSP00000340211.5, ENST00000341356.10
      Conserved Domains (2) summary
      sd00039
      Location:38 → 80
      7WD40; WD40 repeat [structural motif]
      cl25676
      Location:10 → 485
      WD40_4; Type of WD40 repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      67435510..67443809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      67429626..67437925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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