U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    TMEM174 transmembrane protein 174 [ Homo sapiens (human) ]

    Gene ID: 134288, updated on 10-Dec-2024

    Summary

    Official Symbol
    TMEM174provided by HGNC
    Official Full Name
    transmembrane protein 174provided by HGNC
    Primary source
    HGNC:HGNC:28187
    See related
    Ensembl:ENSG00000164325 MIM:614909; AllianceGenome:HGNC:28187
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be involved in phosphate ion homeostasis. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward kidney (RPKM 66.3) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TMEM174 in Genome Data Viewer
    Location:
    5q13.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (73173193..73175143)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (73654534..73656484)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (72469020..72470970)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379030 Neighboring gene 40S ribosomal protein S3-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:72451076-72451576 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:72451577-72452077 Neighboring gene uncharacterized LOC340090 Neighboring gene uncharacterized LOC124901002 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16087 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:72525833-72526458 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:72528715-72529663 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:72542107-72542607 Neighboring gene uncharacterized LOC105379031

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (10 hits/1234 screens)

    EBI GWAS Catalog

    Description
    Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
    EBI GWAS Catalog

    Interactions

    General gene information

    Clone Names

    • FLJ31268, MGC13034

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in phosphate ion homeostasis  
    Component Evidence Code Pubs
    located_in apical plasma membrane  
    located_in endoplasmic reticulum membrane PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153217.3NP_694949.1  transmembrane protein 174

      See identical proteins and their annotated locations for NP_694949.1

      Status: VALIDATED

      Source sequence(s)
      AC116345, AK315460
      Consensus CDS
      CCDS4018.1
      UniProtKB/Swiss-Prot
      B2RDA0, Q8WUU8, Q96N81
      Related
      ENSP00000296776.5, ENST00000296776.6
      Conserved Domains (1) summary
      pfam15029
      Location:9241
      TMEM174; Transmembrane protein 174

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      73173193..73175143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      73654534..73656484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.