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    ZNF628 zinc finger protein 628 [ Homo sapiens (human) ]

    Gene ID: 89887, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF628provided by HGNC
    Official Full Name
    zinc finger protein 628provided by HGNC
    Primary source
    HGNC:HGNC:28054
    See related
    Ensembl:ENSG00000197483 MIM:610671; AllianceGenome:HGNC:28054
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZEC; Zfp628
    Summary
    Zinc finger proteins (ZNFs), which bind nucleic acids, perform many key functions, the most important of which is regulating transcription. See ZNF91 (MIM 603971) for general information on ZNFs.[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in testis (RPKM 3.1), spleen (RPKM 1.1) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF628 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (55476617..55484487)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (58572887..58580760)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55987984..55995854)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11034 Neighboring gene isochorismatase domain containing 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55974394-55975116 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55975839-55976561 Neighboring gene chromosome 19 open reading frame 85 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11035 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11037 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:55988382-55988705 Neighboring gene Sharpr-MPRA regulatory region 3758 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11038 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15097 Neighboring gene N-acetyltransferase 14 (putative) Neighboring gene scavenger receptor cysteine rich family member with 5 domains Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11039 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11040 Neighboring gene Sharpr-MPRA regulatory region 5021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56028273-56028774

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. ZEC, a zinc finger protein with novel binding specificity and transcription regulatory activity. Chen GY, et al. Gene, 2004 Sep 29. PMID 15556296
    2. CCAT1/FABP5 promotes tumour progression through mediating fatty acid metabolism and stabilizing PI3K/AKT/mTOR signalling in lung adenocarcinoma. Chen J, et al. J Cell Mol Med, 2021 Oct. PMID 34431227, Free PMC Article
    3. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. Li S, et al. Proc Natl Acad Sci U S A, 2014 May 13. PMID 24778252, Free PMC Article
    4. A dual-activity topoisomerase complex regulates mRNA translation and turnover. Su S, et al. Nucleic Acids Res, 2022 Jul 8. PMID 35748872, Free PMC Article
    5. Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy. Sun X, et al. Acta Pharm Sin B, 2022 Feb. PMID 35256949, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105139

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 628
    Names
    zinc finger protein Zec

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033113.3 → NP_149104.3  zinc finger protein 628

      See identical proteins and their annotated locations for NP_149104.3

      Status: VALIDATED

      Source sequence(s)
      AC008735, BC016036, BC089449
      Consensus CDS
      CCDS33116.3
      UniProtKB/Swiss-Prot
      Q5EBL2, Q86X34
      Related
      ENSP00000469591.1, ENST00000598519.2
      Conserved Domains (4) summary
      COG5048
      Location:43 → 213
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:150 → 170
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:361 → 378
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:204 → 226
      zf-C2H2; Zinc finger, C2H2 type

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      55476617..55484487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      58572887..58580760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5EBL2.3 GenPept UniProtKB/Swiss-Prot:Q5EBL2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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