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    C22orf46P chromosome 22 open reading frame 46, pseudogene [ Homo sapiens (human) ]

    Gene ID: 79640, updated on 10-Dec-2024

    Summary

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    Official Symbol
    C22orf46Pprovided by HGNC
    Official Full Name
    chromosome 22 open reading frame 46, pseudogeneprovided by HGNC
    Primary source
    HGNC:HGNC:26294
    See related
    Ensembl:ENSG00000293428 AllianceGenome:HGNC:26294
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C22orf46
    Expression
    Ubiquitous expression in testis (RPKM 7.6), brain (RPKM 5.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See C22orf46P in Genome Data Viewer
    Location:
    22q13.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (41688937..41698136)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (42167914..42177110)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (42084941..42094140)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene protein LLP homolog Neighboring gene RNA, U6 small nuclear 476, pseudogene Neighboring gene small nuclear ribonucleoprotein 13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19125 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:42084352-42084551 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19126 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19128 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13796 Neighboring gene meiotic double-stranded break formation protein 1 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene10 Neighboring gene RNA, U6atac small nuclear 22, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Nucleolar protein TAAP1/C22orf46 confers pro-survival signaling in non-small cell lung cancer. Döring M, et al. Life Sci Alliance, 2024 Apr. PMID 38228372, Free PMC Article
    2. Circular RNA circ-CCAC1 Facilitates Adrenocortical Carcinoma Cell Proliferation, Migration, and Invasion through Regulating the miR-514a-5p/C22orf46 Axis. Li W, et al. Biomed Res Int, 2020. PMID 33195693, Free PMC Article
    3. N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cheng Y, et al. Cancer Cell, 2021 Jul 12. PMID 34048709, Free PMC Article
    4. Functional proteomics mapping of a human signaling pathway. Colland F, et al. Genome Res, 2004 Jul. PMID 15231748, Free PMC Article
    5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. Oláh J, et al. J Biol Chem, 2011 Sep 30. PMID 21832049, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nucleolar protein TAAP1/C22orf46 confers pro-survival signaling in non-small cell lung cancer.
      Title: Nucleolar protein TAAP1/C22orf46 confers pro-survival signaling in non-small cell lung cancer.
    2. Circular RNA circ-CCAC1 Facilitates Adrenocortical Carcinoma Cell Proliferation, Migration, and Invasion through Regulating the miR-514a-5p/C22orf46 Axis.
      Title: Circular RNA circ-CCAC1 Facilitates Adrenocortical Carcinoma Cell Proliferation, Migration, and Invasion through Regulating the miR-514a-5p/C22orf46 Axis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • CTA-216E10.6
    • uncharacterized protein C22orf46

    Clone Names

    • FLJ23584

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_160905.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      Z83840
      Related
      ENST00000656592.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      41688937..41698136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      42167914..42177110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001142964.1: Suppressed sequence

      Description
      NM_001142964.1: This RefSeq was removed because it is now thought that this gene is a pseudogene.

    2. NM_024588.3: Suppressed sequence

      Description
      NM_024588.3: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version

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