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    PA2G4 proliferation-associated 2G4 [ Homo sapiens (human) ]

    Gene ID: 5036, updated on 10-Dec-2024

    Summary

    Official Symbol
    PA2G4provided by HGNC
    Official Full Name
    proliferation-associated 2G4provided by HGNC
    Primary source
    HGNC:HGNC:8550
    See related
    Ensembl:ENSG00000170515 MIM:602145; AllianceGenome:HGNC:8550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EBP1; HG4-1; ITAF45; p38-2G4
    Summary
    This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in skin (RPKM 37.0), esophagus (RPKM 35.3) and 25 other tissues See more
    Orthologs
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    Genomic context

    See PA2G4 in Genome Data Viewer
    Location:
    12q13.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (56104559..56113910)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (56072163..56081516)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56498343..56507694)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:56473606-56474596 Neighboring gene erb-b2 receptor tyrosine kinase 3 Neighboring gene uncharacterized LOC105369782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6471 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:56514939-56515936 Neighboring gene ribosomal protein L41 Neighboring gene zinc finger CCCH-type containing 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6472

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (240 hits/1251 screens)

    EBI GWAS Catalog

    Description
    Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr downregulates proliferation-associated protein 2G4 (PA2G4) and upregulates p53 in glioblastoma U87MG cells PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human proliferation-associated 2G4, 38kDa (PA2G4) at amino acid residues 346-347 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in azurophil granule lumen  
    located_in cytoplasm PubMed 
    located_in extracellular exosome PubMed 
    located_in extracellular region  
    located_in membrane PubMed 
    located_in nucleolus PubMed 
    located_in nucleus PubMed 
    part_of ribonucleoprotein complex  

    General protein information

    Preferred Names
    proliferation-associated protein 2G4
    Names
    ErbB-3 binding protein 1
    ErbB-3 receptor binding protein
    ErbB3-binding protein Ebp1
    IRES-specific cellular transacting factor 45
    cell cycle protein p38-2G4 homolog
    erbB3-binding protein 1
    proliferation-associated 2G4, 38kD
    proliferation-associated 2G4, 38kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006191.3 → NP_006182.2  proliferation-associated protein 2G4

      See identical proteins and their annotated locations for NP_006182.2

      Status: REVIEWED

      Source sequence(s)
      AC034102, BC001951, BU683753
      Consensus CDS
      CCDS8902.1
      UniProtKB/Swiss-Prot
      O43846, Q9UM59, Q9UQ80
      UniProtKB/TrEMBL
      A8K6Y1
      Related
      ENSP00000302886.6, ENST00000303305.11
      Conserved Domains (1) summary
      TIGR00495
      Location:1 → 388
      crvDNA_42K; 42K curved DNA binding protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      56104559..56113910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      56072163..56081516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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