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    SNAP23 synaptosome associated protein 23 [ Homo sapiens (human) ]

    Gene ID: 8773, updated on 10-Dec-2024

    Summary

    Official Symbol
    SNAP23provided by HGNC
    Official Full Name
    synaptosome associated protein 23provided by HGNC
    Primary source
    HGNC:HGNC:11131
    See related
    Ensembl:ENSG00000092531 MIM:602534; AllianceGenome:HGNC:11131
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SNAP-23; SNAP23A; SNAP23B; HsT17016
    Summary
    Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 25.6), appendix (RPKM 23.5) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SNAP23 in Genome Data Viewer
    Location:
    15q15.1-q15.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (42491129..42533058)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (40297171..40339102)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (42787832..42825256)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene calpain 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:42676684-42677239 Neighboring gene uncharacterized LOC105370794 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:42677734-42678933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9300 Neighboring gene zinc finger protein 106 Neighboring gene RNA, U6 small nuclear 188, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:42749529-42750361 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:42750362-42751193 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9303 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:42787505-42788048 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:42788049-42788592 Neighboring gene MPRA-validated peak2311 silencer Neighboring gene leucine rich repeat containing 57 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9304 Neighboring gene HAUS augmin like complex subunit 2 Neighboring gene MYL12B pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SNAP receptor activity  
    enables protein binding PubMed 
    enables syntaxin binding  
    enables syntaxin binding PubMed 
    Process Evidence Code Pubs
    involved_in exocytosis  
    involved_in histamine secretion by mast cell PubMed 
    involved_in membrane fusion PubMed 
    involved_in post-Golgi vesicle-mediated transport PubMed 
    involved_in protein transport  
    involved_in synaptic vesicle fusion to presynaptic active zone membrane  
    involved_in synaptic vesicle priming  
    involved_in vesicle targeting PubMed 
    Component Evidence Code Pubs
    part_of SNARE complex  
    part_of SNARE complex PubMed 
    located_in adherens junction PubMed 
    located_in azurophil granule PubMed 
    located_in cytoplasm PubMed 
    located_in extracellular exosome PubMed 
    located_in focal adhesion PubMed 
    located_in mitochondrion PubMed 
    located_in neuron projection  
    located_in nucleoplasm  
    located_in phagocytic vesicle membrane  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in presynapse  
    located_in specific granule PubMed 
    located_in specific granule membrane  
    located_in tertiary granule membrane  

    General protein information

    Preferred Names
    synaptosomal-associated protein 23
    Names
    synaptosomal-associated protein, 23kD
    synaptosomal-associated protein, 23kDa
    synaptosome associated protein 23kDa
    vesicle-membrane fusion protein SNAP-23

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003825.4 → NP_003816.2  synaptosomal-associated protein 23 isoform SNAP23A

      See identical proteins and their annotated locations for NP_003816.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longer transcript, containing eight exons and encoding the full-length isoform (SNAP23A).
      Source sequence(s)
      AK290152, BC022890, BM782600
      Consensus CDS
      CCDS10087.1
      UniProtKB/Swiss-Prot
      O00161, O00162, Q13602, Q6IAE3
      UniProtKB/TrEMBL
      A8K287
      Related
      ENSP00000249647.3, ENST00000249647.8
      Conserved Domains (3) summary
      cd15884
      Location:149 → 207
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:9 → 75
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:86 → 147
      SNAP-25; SNAP-25 family
    2. NM_130798.3 → NP_570710.1  synaptosomal-associated protein 23 isoform SNAP23B

      See identical proteins and their annotated locations for NP_570710.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks internal exon 6 but maintains the same reading frame as compared to transcript variant 1. It encodes an isoform (SNAP23B) which is missing 53 aa as compared to the full-length isoform (SNAP23A) encoded by transcript variant 1. The missing region is required for nonspecific binding of the protein to plasma membranes, indicating a functional difference between isoforms SNAP23A and SNAP23B.
      Source sequence(s)
      AK290152, BC022890, BM782600, DA650133
      Consensus CDS
      CCDS10088.1
      Related
      ENSP00000207062.1, ENST00000349777.5
      Conserved Domains (2) summary
      cd15884
      Location:96 → 154
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cl22856
      Location:9 → 75
      SNARE; SNARE motif

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      42491129..42533058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433203.1 → XP_047289159.1  synaptosomal-associated protein 23 isoform X2

      UniProtKB/Swiss-Prot
      O00161, O00162, Q13602, Q6IAE3
      UniProtKB/TrEMBL
      A8K287
    2. XM_017022694.2 → XP_016878183.2  synaptosomal-associated protein 23 isoform X2

      UniProtKB/Swiss-Prot
      O00161, O00162, Q13602, Q6IAE3
      UniProtKB/TrEMBL
      A8K287
    3. XM_047433202.1 → XP_047289158.1  synaptosomal-associated protein 23 isoform X2

      UniProtKB/Swiss-Prot
      O00161, O00162, Q13602, Q6IAE3
      UniProtKB/TrEMBL
      A8K287
    4. XM_047433199.1 → XP_047289155.1  synaptosomal-associated protein 23 isoform X1

    5. XM_047433200.1 → XP_047289156.1  synaptosomal-associated protein 23 isoform X1

    6. XM_006720725.4 → XP_006720788.1  synaptosomal-associated protein 23 isoform X1

      See identical proteins and their annotated locations for XP_006720788.1

      Conserved Domains (3) summary
      cd15884
      Location:160 → 218
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:9 → 75
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:100 → 158
      SNAP-25; SNAP-25 family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      40297171..40339102
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379043.1 → XP_054235018.1  synaptosomal-associated protein 23 isoform X2

      UniProtKB/Swiss-Prot
      O00161, O00162, Q13602, Q6IAE3
      UniProtKB/TrEMBL
      A8K287
    2. XM_054379042.1 → XP_054235017.1  synaptosomal-associated protein 23 isoform X2

      UniProtKB/Swiss-Prot
      O00161, O00162, Q13602, Q6IAE3
      UniProtKB/TrEMBL
      A8K287
    3. XM_054379041.1 → XP_054235016.1  synaptosomal-associated protein 23 isoform X2

      UniProtKB/Swiss-Prot
      O00161, O00162, Q13602, Q6IAE3
      UniProtKB/TrEMBL
      A8K287
    4. XM_054379040.1 → XP_054235015.1  synaptosomal-associated protein 23 isoform X1

    5. XM_054379039.1 → XP_054235014.1  synaptosomal-associated protein 23 isoform X1

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