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    MYO1D myosin ID [ Homo sapiens (human) ]

    Gene ID: 4642, updated on 10-Dec-2024

    Summary

    Official Symbol
    MYO1Dprovided by HGNC
    Official Full Name
    myosin IDprovided by HGNC
    Primary source
    HGNC:HGNC:7598
    See related
    Ensembl:ENSG00000176658 MIM:606539; AllianceGenome:HGNC:7598
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    myr4; PPP1R108
    Summary
    Enables protein domain specific binding activity. Predicted to be involved in several processes, including actin filament organization; actin filament-based movement; and early endosome to recycling endosome transport. Located in extracellular exosome. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in colon (RPKM 49.5), small intestine (RPKM 32.7) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MYO1D in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (32492522..32877124, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (33438289..33823203, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (30819540..31204142, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:30771309-30771924 Neighboring gene proteasome 26S subunit, non-ATPase 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:30812797-30813298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8422 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8423 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:30814538-30815097 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:30817300-30817421 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12031 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8425 Neighboring gene uncharacterized LOC124903982 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:30824438-30824945 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:30830591-30831361 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:30832133-30832903 Neighboring gene uncharacterized LOC105371734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12032 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12033 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12034 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8426 Neighboring gene uncharacterized LOC107985012 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8427 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:30849483-30850006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:30850007-30850529 Neighboring gene cyclin dependent kinase 5 regulatory subunit 1 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:30873137-30873636 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12035 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12036 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:31010379-31011000 Neighboring gene MPRA-validated peak2803 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8428 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8429 Neighboring gene Sharpr-MPRA regulatory region 12414 Neighboring gene uncharacterized LOC124903981 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12038 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12039 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:31203674-31203861 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:31213662-31214258 Neighboring gene CRISPRi-validated MYO1D non-hub enhancer 1 Neighboring gene CRISPRi-validated cis-regulatory element chr17.1747 Neighboring gene Sharpr-MPRA regulatory region 12135 Neighboring gene MYO1D divergent transcript Neighboring gene CRISPRi-validated MYO1D hub enhancer Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:31244864-31245495 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:31262798-31263448 Neighboring gene Sharpr-MPRA regulatory region 812 Neighboring gene H2B.N variant histone 1 Neighboring gene transmembrane protein 98

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (9 hits/1260 screens)

    EBI GWAS Catalog

    Description
    Genetic association of short sleep duration with hypertension incidence--a 6-year follow-up in the Korean genome and epidemiology study.
    EBI GWAS Catalog
    Genome-Wide Association Identifies Regulatory Loci Associated with Distinct Local Histogram Emphysema Patterns.
    EBI GWAS Catalog
    Genome-wide association study of pancreatic cancer in Japanese population.
    EBI GWAS Catalog
    Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
    EBI GWAS Catalog

    Interactions

    General gene information

    Clone Names

    • KIAA0727

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding  
    enables actin filament binding  
    enables actin filament binding  
    enables calcium-dependent protein binding  
    enables calmodulin binding  
    enables microfilament motor activity  
    enables microfilament motor activity  
    enables protein binding PubMed 
    enables protein domain specific binding PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization  
    involved_in actin filament-based movement  
    involved_in cellular localization  
    involved_in early endosome to recycling endosome transport  
    involved_in endocytosis  
    involved_in protein transport  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton  
    located_in apical dendrite  
    located_in axolemma  
    located_in axon  
    located_in basolateral plasma membrane  
    located_in brush border  
    located_in cell cortex  
    is_active_in cytoplasm  
    located_in cytoplasmic vesicle  
    located_in early endosome  
    located_in endosome  
    located_in extracellular exosome PubMed 
    is_active_in microvillus  
    located_in myelin sheath  
    part_of myosin complex  
    located_in neuron projection  
    located_in neuronal cell body  
    located_in perikaryon  
    is_active_in plasma membrane  
    located_in smooth endoplasmic reticulum  

    General protein information

    Preferred Names
    unconventional myosin-Id
    Names
    myosin-I gamma
    protein phosphatase 1, regulatory subunit 108

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303279.2NP_001290208.1  unconventional myosin-Id isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AB018270, AK127942, BC030602, DB363168
      Consensus CDS
      CCDS76991.1
      UniProtKB/TrEMBL
      J3QRN6, Q7Z3N6
      Related
      ENSP00000464305.1, ENST00000579584.5
      Conserved Domains (2) summary
      cd01378
      Location:24682
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:803957
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
    2. NM_001303280.2NP_001290209.1  unconventional myosin-Id isoform 3

      See identical proteins and their annotated locations for NP_001290209.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks multiple 3' coding exons and contains an alternate 3' terminal exon, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      BC030602
      Consensus CDS
      CCDS76992.1
      UniProtKB/TrEMBL
      J3KRL0
      Related
      ENSP00000462055.1, ENST00000583621.1
      Conserved Domains (1) summary
      cl22853
      Location:24433
      Motor_domain; Myosin and Kinesin motor domain
    3. NM_001411088.1NP_001398017.1  unconventional myosin-Id isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC007982, AC025211, AC079336, AC084809
      Consensus CDS
      CCDS92288.1
      UniProtKB/TrEMBL
      K7EIG7, Q7Z3N6
      Related
      ENSP00000464741.1, ENST00000394649.8
    4. NM_015194.3NP_056009.1  unconventional myosin-Id isoform 1

      See identical proteins and their annotated locations for NP_056009.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AB018270, AC007982, BC030602, BC030796
      Consensus CDS
      CCDS32615.1
      UniProtKB/Swiss-Prot
      A6H8V3, O94832, Q8NHP9
      UniProtKB/TrEMBL
      Q7Z3N6
      Related
      ENSP00000324527.5, ENST00000318217.10
      Conserved Domains (3) summary
      smart00242
      Location:4694
      MYSc; Myosin. Large ATPases
      cd01378
      Location:24682
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:803997
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      32492522..32877124 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024685.3XP_016880174.1  unconventional myosin-Id isoform X1

      UniProtKB/TrEMBL
      Q7Z3N6

    RNA

    1. XR_001752521.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      33438289..33823203 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316247.1XP_054172222.1  unconventional myosin-Id isoform X1

      UniProtKB/TrEMBL
      Q7Z3N6

    RNA

    1. XR_008484823.1 RNA Sequence

    2. XR_008484822.1 RNA Sequence

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