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    IL5RA interleukin 5 receptor subunit alpha [ Homo sapiens (human) ]

    Gene ID: 3568, updated on 10-Dec-2024

    Summary

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    Official Symbol
    IL5RAprovided by HGNC
    Official Full Name
    interleukin 5 receptor subunit alphaprovided by HGNC
    Primary source
    HGNC:HGNC:6017
    See related
    Ensembl:ENSG00000091181 MIM:147851; AllianceGenome:HGNC:6017
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IL5R; CD125; CDw125; HSIL5R3
    Summary
    The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]
    Expression
    Biased expression in lung (RPKM 1.2), prostate (RPKM 0.7) and 13 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IL5RA in Genome Data Viewer
    Location:
    3p26.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (3066324..3110374, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (3060643..3104729, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (3108008..3152058, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene contactin 4 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 4 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_69430 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:3079797-3080996 Neighboring gene CNTN4 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14007 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14008 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19343 Neighboring gene uncharacterized LOC124909339 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14009 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:3168955-3169685 Neighboring gene tRNA nucleotidyl transferase 1 Neighboring gene cereblon

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling. Caveney NA, et al. Mol Cell, 2024 May 16. PMID 38614096,
    2. Separate endocytic pathways regulate IL-5 receptor internalization and signaling. Lei JT, et al. J Leukoc Biol, 2008 Aug. PMID 18511572, Free PMC Article
    3. JAK kinases control IL-5 receptor ubiquitination, degradation, and internalization. Martinez-Moczygemba M, et al. J Leukoc Biol, 2007 Apr. PMID 17227823
    4. Asymmetric usage of antagonist charged residues drives interleukin-5 receptor recruitment but is insufficient for receptor activation. Ishino T, et al. Biochemistry, 2006 Jan 31. PMID 16430207, Free PMC Article
    5. Differential expression of the interleukin 5 receptor alpha isoforms in blood and tissue eosinophils of nasal polyp patients. Gevaert P, et al. Allergy, 2009 May. PMID 19170670

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling.
      Title: Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling.
    2. Epithelial IL5RA promotes epithelial-mesenchymal transition in pulmonary fibrosis via Jak2/STAT3 cascade.
      Title: Epithelial IL5RA promotes epithelial-mesenchymal transition in pulmonary fibrosis via Jak2/STAT3 cascade.
    3. The Study of the Influence of IL5RA Variants on Chronic Obstructive Pulmonary Disease.
      Title: The Study of the Influence of IL5RA Variants on Chronic Obstructive Pulmonary Disease.
    4. IL5RA as an immunogenic cell death-related predictor in progression and therapeutic response of multiple myeloma.
      Title: IL5RA as an immunogenic cell death-related predictor in progression and therapeutic response of multiple myeloma.
    5. Transcriptional Regulation of the Human IL5RA Gene through Alternative Promoter Usage during Eosinophil Development.
      Title: Transcriptional Regulation of the Human IL5RA Gene through Alternative Promoter Usage during Eosinophil Development.
    6. MiRNA-495-3p Attenuates TNF-alpha Induced Apoptosis and Inflammation in Human Nucleus Pulposus Cells by Targeting IL5RA.
      Title: MiRNA-495-3p Attenuates TNF-α Induced Apoptosis and Inflammation in Human Nucleus Pulposus Cells by Targeting IL5RA.
    7. Treatment Challenges in Severe Eosinophilic Asthma: Differential Response to Anti-IL-5 and Anti-IL-5R Therapy.
      Title: Treatment Challenges in Severe Eosinophilic Asthma: Differential Response to Anti-IL-5 and Anti-IL-5R Therapy.
    8. Ceruloplasmin and oxidative stress in severe eosinophilic asthma patients treated with Mepolizumab and Benralizumab.
      Title: Ceruloplasmin and oxidative stress in severe eosinophilic asthma patients treated with Mepolizumab and Benralizumab.
    9. IL-5Ralpha marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease.
      Title: IL-5Rα marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease.
    10. Expression of IL-5 receptor alpha by murine and human lung neutrophils.
      Title: Expression of IL-5 receptor alpha by murine and human lung neutrophils.
    Submit: New GeneRIF Correction See all GeneRIFs (45)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
    EBI GWAS Catalog
    Genome-wide association study of antibody response to smallpox vaccine.
    EBI GWAS Catalog
    Genome-wide association study of the age of onset of childhood asthma.
    EBI GWAS Catalog
    Impact of ancestry and common genetic variants on QT interval in African Americans.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC26560

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-5 receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in interleukin-5-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of leukocyte proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of interleukin-5 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-5 receptor subunit alpha
    Names
    CD125 antigen
    IL-5 receptor subunit alpha
    IL-5R subunit alpha
    interleukin 5 receptor type 3
    interleukin 5 receptor, alpha
    interleukin-5 receptor alpha chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029547.1 RefSeqGene

      Range
      5001..49051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000564.5 → NP_000555.2  interleukin-5 receptor subunit alpha isoform 1 precursor

      See identical proteins and their annotated locations for NP_000555.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 4 both encode the same isoform (1).
      Source sequence(s)
      AC022002, AC024060, AK304256, BX118481, DB222974, M96652, X61176
      Consensus CDS
      CCDS2559.1
      UniProtKB/Swiss-Prot
      B3IU77, B4E2G0, Q01344, Q14633, Q15469, Q6ISX9
      UniProtKB/TrEMBL
      Q14631
      Related
      ENSP00000256452.3, ENST00000256452.7
      Conserved Domains (2) summary
      pfam09240
      Location:129 → 236
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      cl21522
      Location:25 → 107
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    2. NM_001243099.2 → NP_001230028.1  interleukin-5 receptor subunit alpha isoform 4 precursor

      See identical proteins and their annotated locations for NP_001230028.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC022002, AC024060, AK304256, BX118481
      Consensus CDS
      CCDS58813.1
      UniProtKB/TrEMBL
      Q14631
      Related
      ENSP00000390753.1, ENST00000438560.5
      Conserved Domains (2) summary
      pfam09240
      Location:129 → 236
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      cl21522
      Location:25 → 107
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    3. NM_175724.2 → NP_783851.1  interleukin-5 receptor subunit alpha isoform 2 precursor

      See identical proteins and their annotated locations for NP_783851.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' end region, which leads to a translation frameshift, when compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      AC024060, BI520196, DB229011, M96651, X62156
      Consensus CDS
      CCDS46739.1
      UniProtKB/TrEMBL
      Q8NHV7
      Related
      ENSP00000400400.2, ENST00000430514.6
      Conserved Domains (2) summary
      pfam09240
      Location:129 → 236
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      cl21522
      Location:25 → 107
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    4. NM_175725.3 → NP_783852.1  interleukin-5 receptor subunit alpha isoform 3 precursor

      See identical proteins and their annotated locations for NP_783852.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' end region, which leads to a translation frameshift, when compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      AC024060, BI520196, DB229011, M75914, X62156
      Consensus CDS
      CCDS2560.1
      UniProtKB/TrEMBL
      Q8NHV7
      Related
      ENSP00000309196.8, ENST00000311981.12
      Conserved Domains (2) summary
      pfam09240
      Location:129 → 236
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      cl21522
      Location:25 → 107
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    5. NM_175726.4 → NP_783853.1  interleukin-5 receptor subunit alpha isoform 1 precursor

      See identical proteins and their annotated locations for NP_783853.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an internal segment within the 5' UTR, as compared to variant 1. Variants 1 and 4 encode the same isoform (1).
      Source sequence(s)
      AC022002, AK304256, BX118481, DB222974, M96652, X61176
      Consensus CDS
      CCDS2559.1
      UniProtKB/Swiss-Prot
      B3IU77, B4E2G0, Q01344, Q14633, Q15469, Q6ISX9
      UniProtKB/TrEMBL
      Q14631
      Related
      ENSP00000412209.2, ENST00000446632.7
      Conserved Domains (2) summary
      pfam09240
      Location:129 → 236
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      cl21522
      Location:25 → 107
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    6. NM_175727.2 → NP_783854.1  interleukin-5 receptor subunit alpha isoform 2 precursor

      See identical proteins and their annotated locations for NP_783854.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an internal segment within the 5' UTR, and differs in the 3' end region, when compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      BI520196, DB229011, M96651, X62156
      Consensus CDS
      CCDS46739.1
      UniProtKB/TrEMBL
      Q8NHV7
      Related
      ENSP00000392059.1, ENST00000456302.5
      Conserved Domains (2) summary
      pfam09240
      Location:129 → 236
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      cl21522
      Location:25 → 107
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    7. NM_175728.3 → NP_783855.1  interleukin-5 receptor subunit alpha isoform 3 precursor

      See identical proteins and their annotated locations for NP_783855.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an internal segment within the 5' UTR, and differs in the 3' end region, when compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      BC027599, BI520196, DB229011, M75914, X62156
      Consensus CDS
      CCDS2560.1
      UniProtKB/TrEMBL
      Q8NHV7
      Related
      ENSP00000373358.1, ENST00000383846.5
      Conserved Domains (2) summary
      pfam09240
      Location:129 → 236
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      cl21522
      Location:25 → 107
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      3066324..3110374 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011533677.2 → XP_011531979.1  interleukin-5 receptor subunit alpha isoform X1

      See identical proteins and their annotated locations for XP_011531979.1

      UniProtKB/TrEMBL
      Q14631
      Conserved Domains (2) summary
      pfam09240
      Location:129 → 236
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      cl21522
      Location:25 → 107
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    2. XM_011533678.3 → XP_011531980.1  interleukin-5 receptor subunit alpha isoform X1

      See identical proteins and their annotated locations for XP_011531980.1

      UniProtKB/TrEMBL
      Q14631
      Conserved Domains (2) summary
      pfam09240
      Location:129 → 236
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      cl21522
      Location:25 → 107
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      3060643..3104729 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346456.1 → XP_054202431.1  interleukin-5 receptor subunit alpha isoform X1

      UniProtKB/TrEMBL
      Q14631

    2. XM_054346455.1 → XP_054202430.1  interleukin-5 receptor subunit alpha isoform X1

      UniProtKB/TrEMBL
      Q14631
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01344.2 GenPept UniProtKB/Swiss-Prot:Q01344

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