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    WT1-AS WT1 antisense RNA [ Homo sapiens (human) ]

    Gene ID: 51352, updated on 10-Dec-2024

    Summary

    Official Symbol
    WT1-ASprovided by HGNC
    Official Full Name
    WT1 antisense RNAprovided by HGNC
    Primary source
    HGNC:HGNC:18135
    See related
    Ensembl:ENSG00000183242 MIM:607899; AllianceGenome:HGNC:18135
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    WIT1; WIT-1; WT1AS; WT1-AS1
    Summary
    This gene is located upstream of the Wilms tumor 1 (WT1) gene; these two genes are bi-directionally transcribed from the same promoter region. This gene is imprinted in kidney, with preferential expression from the paternal allele. Imprinting defects at chromosome 11p13 may contribute to tumorigenesis. [provided by RefSeq, May 2014]
    Expression
    Biased expression in ovary (RPKM 4.7), endometrium (RPKM 3.7) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See WT1-AS in Genome Data Viewer
    Location:
    11p13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (32435518..32458769)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (32571003..32594257)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (32457064..32480315)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984322 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4563 Neighboring gene thioesterase superfamily member 7, pseudogene Neighboring gene small nucleolar RNA, H/ACA box 88 Neighboring gene HCNE2 enhancer upstream of PAX6 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:32380174-32380395 Neighboring gene WT1 3' enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3221 Neighboring gene WT1 intron 3 regulatory region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:32449464-32450078 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:32450079-32450691 Neighboring gene WT1/WT1-AS bi-directional promoter region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:32459559-32460416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:32460417-32461272 Neighboring gene Sharpr-MPRA regulatory region 1868 Neighboring gene WT1 transcription factor Neighboring gene MPRA-validated peak1243 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4564 Neighboring gene MPRA-validated peak1244 silencer Neighboring gene MPRA-validated peak1246 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:32605088-32605740 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3223 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 9 Neighboring gene eukaryotic translation initiation factor 3 subunit M Neighboring gene coiled-coil domain containing 73 Neighboring gene 60S ribosomal protein L34-like Neighboring gene ribosomal protein L34 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Other Names

    • WT1 antisense RNA (non-protein coding)
    • Wilms tumor associated protein
    • Wilms tumor upstream neighbor 1

    Clone Names

    • MGC120207, MGC120208, MGC120209

    Gene Ontology Provided by GOA

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_023920.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon, contains an alternate 5' exon, and differs in the 3' exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AL049692, DA743604, DB262871, DQ289488
    2. NR_120546.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      DQ289489, DQ289490
    3. NR_120547.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon and contains two alternate 5' exons, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AL049692
    4. NR_120548.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) shares no exons with variant 1, but contains the same 5' exon as variant 2 and four alternate 3' exons. The transcript is shorter than variants 1 and 2.
      Source sequence(s)
      AL049692
      Related
      ENST00000525436.2
    5. NR_120549.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) shares no exons with variant 1, but contains the same 5' exon as variant 2 and an alternate 3' exon. The transcript is shorter than variants 1 and 2.
      Source sequence(s)
      AL049692
      Related
      ENST00000459866.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      32435518..32458769
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      32571003..32594257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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