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    FOXJ3 forkhead box J3 [ Homo sapiens (human) ]

    Gene ID: 22887, updated on 10-Dec-2024

    Summary

    Official Symbol
    FOXJ3provided by HGNC
    Official Full Name
    forkhead box J3provided by HGNC
    Primary source
    HGNC:HGNC:29178
    See related
    Ensembl:ENSG00000198815 MIM:616035; AllianceGenome:HGNC:29178
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 10.6), testis (RPKM 10.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FOXJ3 in Genome Data Viewer
    Location:
    1p34.2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (42176548..42335880, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (42047196..42206280, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (42642219..42801551, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:42630276-42631240 Neighboring gene Sharpr-MPRA regulatory region 9331 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:42638778-42639405 Neighboring gene guanylate cyclase activator 2B Neighboring gene guanylate cyclase activator 2A Neighboring gene Sharpr-MPRA regulatory region 10195 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 757 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:42799881-42800838 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 759 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 761 Neighboring gene ribosomal modification protein rimK like family member A Neighboring gene ribosomal protein S15a pseudogene 8 Neighboring gene zinc finger MYND-type containing 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC165036, MGC176686

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cell differentiation  
    involved_in male meiosis I  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    involved_in spermatogenesis  
    Component Evidence Code Pubs
    located_in chromatin  
    is_active_in nucleus  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198850.2NP_001185779.1  forkhead box protein J3 isoform 1

      See identical proteins and their annotated locations for NP_001185779.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC096540, AK027075, BC063298, BC151828
      Consensus CDS
      CCDS30689.1
      UniProtKB/Swiss-Prot
      A7MBL7, A7MD18, D3DPW2, Q9NSS7, Q9UPW0
      Related
      ENSP00000361654.1, ENST00000372573.5
      Conserved Domains (2) summary
      pfam00250
      Location:78155
      Forkhead; Forkhead domain
      pfam15258
      Location:339445
      FAM222A; Protein family of FAM222A
    2. NM_001198851.2NP_001185780.1  forkhead box protein J3 isoform 1

      See identical proteins and their annotated locations for NP_001185780.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has two additional exons in the 5' UTR, as compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AK027075, BC063298, BC151828, BC152441
      Consensus CDS
      CCDS30689.1
      UniProtKB/Swiss-Prot
      A7MBL7, A7MD18, D3DPW2, Q9NSS7, Q9UPW0
      Related
      ENSP00000361653.1, ENST00000372572.5
      Conserved Domains (2) summary
      pfam00250
      Location:78155
      Forkhead; Forkhead domain
      pfam15258
      Location:339445
      FAM222A; Protein family of FAM222A
    3. NM_001198852.2NP_001185781.1  forkhead box protein J3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AB028964, AC096540, AK027075, BC014182, BC063298, BC151828
      Consensus CDS
      CCDS55594.1
      UniProtKB/Swiss-Prot
      Q9UPW0
      Related
      ENSP00000354449.1, ENST00000361776.5
      Conserved Domains (1) summary
      pfam00250
      Location:78155
      Forkhead; Forkhead domain
    4. NM_014947.5NP_055762.3  forkhead box protein J3 isoform 1

      See identical proteins and their annotated locations for NP_055762.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variants 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC096540, AK027075, BC063298, BC151828
      Consensus CDS
      CCDS30689.1
      UniProtKB/Swiss-Prot
      A7MBL7, A7MD18, D3DPW2, Q9NSS7, Q9UPW0
      Related
      ENSP00000354620.1, ENST00000361346.6
      Conserved Domains (2) summary
      pfam00250
      Location:78155
      Forkhead; Forkhead domain
      pfam15258
      Location:339445
      FAM222A; Protein family of FAM222A

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      42176548..42335880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449488.1XP_047305444.1  forkhead box protein J3 isoform X5

    2. XM_024454163.2XP_024309931.1  forkhead box protein J3 isoform X2

      UniProtKB/Swiss-Prot
      A7MBL7, A7MD18, D3DPW2, Q9NSS7, Q9UPW0
      Conserved Domains (2) summary
      pfam00250
      Location:78155
      Forkhead; Forkhead domain
      pfam15258
      Location:339445
      FAM222A; Protein family of FAM222A
    3. XM_047449489.1XP_047305445.1  forkhead box protein J3 isoform X5

    4. XM_047449474.1XP_047305430.1  forkhead box protein J3 isoform X2

      UniProtKB/Swiss-Prot
      A7MBL7, A7MD18, D3DPW2, Q9NSS7, Q9UPW0
    5. XM_047449471.1XP_047305427.1  forkhead box protein J3 isoform X2

      UniProtKB/Swiss-Prot
      A7MBL7, A7MD18, D3DPW2, Q9NSS7, Q9UPW0
    6. XM_047449478.1XP_047305434.1  forkhead box protein J3 isoform X2

      UniProtKB/Swiss-Prot
      A7MBL7, A7MD18, D3DPW2, Q9NSS7, Q9UPW0
      Related
      ENSP00000439044.1, ENST00000545068.5
    7. XM_017000693.3XP_016856182.1  forkhead box protein J3 isoform X6

    8. XM_006710458.5XP_006710521.1  forkhead box protein J3 isoform X3

      Conserved Domains (1) summary
      pfam00250
      Location:63140
      Forkhead; Forkhead domain
    9. XM_006710459.4XP_006710522.1  forkhead box protein J3 isoform X4

      Conserved Domains (1) summary
      pfam00250
      Location:86163
      Forkhead; Forkhead domain
    10. XM_005270632.5XP_005270689.1  forkhead box protein J3 isoform X1

      Conserved Domains (1) summary
      pfam00250
      Location:86163
      Forkhead; Forkhead domain
    11. XM_047449486.1XP_047305442.1  forkhead box protein J3 isoform X3

    12. XM_017000694.2XP_016856183.1  forkhead box protein J3 isoform X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      42047196..42206280 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335198.1XP_054191173.1  forkhead box protein J3 isoform X5

    2. XM_054335194.1XP_054191169.1  forkhead box protein J3 isoform X2

    3. XM_054335199.1XP_054191174.1  forkhead box protein J3 isoform X5

    4. XM_054335193.1XP_054191168.1  forkhead box protein J3 isoform X2

    5. XM_054335192.1XP_054191167.1  forkhead box protein J3 isoform X2

    6. XM_054335195.1XP_054191170.1  forkhead box protein J3 isoform X2

    7. XM_054335200.1XP_054191175.1  forkhead box protein J3 isoform X6

    8. XM_054335196.1XP_054191171.1  forkhead box protein J3 isoform X3

    9. XM_054335197.1XP_054191172.1  forkhead box protein J3 isoform X3

    10. XM_054335201.1XP_054191176.1  forkhead box protein J3 isoform X7

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