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    CARHSP1 calcium regulated heat stable protein 1 [ Homo sapiens (human) ]

    Gene ID: 23589, updated on 10-Dec-2024

    Summary

    Official Symbol
    CARHSP1provided by HGNC
    Official Full Name
    calcium regulated heat stable protein 1provided by HGNC
    Primary source
    HGNC:HGNC:17150
    See related
    Ensembl:ENSG00000153048 MIM:616885; AllianceGenome:HGNC:17150
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSDC1; CRHSP24; CRHSP-24
    Summary
    Enables mRNA 3'-UTR binding activity. Predicted to be involved in regulation of mRNA stability. Predicted to be located in P granule; cytoplasmic exosome (RNase complex); and cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 17.9), adrenal (RPKM 11.8) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CARHSP1 in Genome Data Viewer
    Location:
    16p13.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (8852942..8869006, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (8885694..8901743, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (8946799..8962863, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:8891090-8891784 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:8891785-8892479 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7178 Neighboring gene transmembrane protein 186 Neighboring gene phosphomannomutase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7179 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7180 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:8923335-8923936 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:8929774-8930308 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:8930309-8930841 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:8940347-8940938 Neighboring gene uncharacterized LOC100130283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:8953773-8954487 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10355 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:8959743-8960380 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:8960381-8961020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10356 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7181 Neighboring gene CARHSP1 divergent transcript Neighboring gene ReSE screen-validated silencer GRCh37_chr16:8971783-8971898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10357 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:8976345-8976845 Neighboring gene LITAF domain containing

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • MGC111446

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding  
    enables mRNA 3'-UTR binding PubMed 
    enables phosphatase binding PubMed 
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction PubMed 
    involved_in regulation of mRNA stability  
    involved_in regulation of mRNA stability  
    Component Evidence Code Pubs
    located_in P granule  
    located_in P-body  
    is_active_in cytoplasm  
    part_of cytoplasmic exosome (RNase complex)  
    located_in cytosol  

    General protein information

    Preferred Names
    calcium-regulated heat-stable protein 1
    Names
    calcium regulated heat stable protein 1, 24kDa
    calcium-regulated heat-stable protein (24kD)
    calcium-regulated heat-stable protein of 24 kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042476.2 → NP_001035941.1  calcium-regulated heat-stable protein 1

      See identical proteins and their annotated locations for NP_001035941.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AC022167, BC001333, BQ004670, HY090855
      Consensus CDS
      CCDS10537.1
      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9
      Related
      ENSP00000379838.2, ENST00000396593.6
      Conserved Domains (1) summary
      cd04458
      Location:63 → 128
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...
    2. NM_001278260.2 → NP_001265189.1  calcium-regulated heat-stable protein 1

      See identical proteins and their annotated locations for NP_001265189.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AC022167
      Consensus CDS
      CCDS10537.1
      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9
      Related
      ENSP00000481550.1, ENST00000611932.4
      Conserved Domains (1) summary
      cd04458
      Location:63 → 128
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...
    3. NM_001278261.2 → NP_001265190.1  calcium-regulated heat-stable protein 1

      See identical proteins and their annotated locations for NP_001265190.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AC022167
      Consensus CDS
      CCDS10537.1
      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9
      Related
      ENSP00000483591.1, ENST00000618335.4
      Conserved Domains (1) summary
      cd04458
      Location:63 → 128
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...
    4. NM_001278262.2 → NP_001265191.1  calcium-regulated heat-stable protein 1

      See identical proteins and their annotated locations for NP_001265191.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AC022167
      Consensus CDS
      CCDS10537.1
      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9
      Related
      ENSP00000480542.1, ENST00000614449.4
      Conserved Domains (1) summary
      cd04458
      Location:63 → 128
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...
    5. NM_001278263.1 → NP_001265192.1  calcium-regulated heat-stable protein 1

      See identical proteins and their annotated locations for NP_001265192.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AC022167, BM920489, BQ004670, HY090855
      Consensus CDS
      CCDS10537.1
      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9
      Related
      ENSP00000455284.1, ENST00000561530.5
      Conserved Domains (1) summary
      cd04458
      Location:63 → 128
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...
    6. NM_001278264.2 → NP_001265193.1  calcium-regulated heat-stable protein 1

      See identical proteins and their annotated locations for NP_001265193.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AC022167
      Consensus CDS
      CCDS10537.1
      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9
      Related
      ENSP00000480144.1, ENST00000619881.4
      Conserved Domains (1) summary
      cd04458
      Location:63 → 128
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...
    7. NM_001278265.2 → NP_001265194.1  calcium-regulated heat-stable protein 1

      See identical proteins and their annotated locations for NP_001265194.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AC022167
      Consensus CDS
      CCDS10537.1
      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9
      Related
      ENSP00000478055.1, ENST00000610831.4
      Conserved Domains (1) summary
      cd04458
      Location:63 → 128
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...
    8. NM_001278266.2 → NP_001265195.1  calcium-regulated heat-stable protein 1

      See identical proteins and their annotated locations for NP_001265195.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AC022167
      Consensus CDS
      CCDS10537.1
      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9
      Related
      ENSP00000455855.1, ENST00000567554.5
      Conserved Domains (1) summary
      cd04458
      Location:63 → 128
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...
    9. NM_014316.4 → NP_055131.2  calcium-regulated heat-stable protein 1

      See identical proteins and their annotated locations for NP_055131.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1-9 encode the same protein.
      Source sequence(s)
      AC022167
      Consensus CDS
      CCDS10537.1
      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9
      Related
      ENSP00000311847.4, ENST00000311052.10
      Conserved Domains (1) summary
      cd04458
      Location:63 → 128
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      8852942..8869006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522444.3 → XP_011520746.1  calcium-regulated heat-stable protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011520746.1

      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9
      Conserved Domains (1) summary
      cd04458
      Location:63 → 128
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...
    2. XM_047433886.1 → XP_047289842.1  calcium-regulated heat-stable protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9
    3. XM_047433884.1 → XP_047289840.1  calcium-regulated heat-stable protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9
    4. XM_047433885.1 → XP_047289841.1  calcium-regulated heat-stable protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      8885694..8901743 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379981.1 → XP_054235956.1  calcium-regulated heat-stable protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9
    2. XM_054379982.1 → XP_054235957.1  calcium-regulated heat-stable protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9
    3. XM_054379980.1 → XP_054235955.1  calcium-regulated heat-stable protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9
    4. XM_054379983.1 → XP_054235958.1  calcium-regulated heat-stable protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9
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