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    CHD9 chromodomain helicase DNA binding protein 9 [ Homo sapiens (human) ]

    Gene ID: 80205, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CHD9provided by HGNC
    Official Full Name
    chromodomain helicase DNA binding protein 9provided by HGNC
    Primary source
    HGNC:HGNC:25701
    See related
    Ensembl:ENSG00000177200 MIM:616936; AllianceGenome:HGNC:25701
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AD013; CHD-9; CReMM; KISH2; PRIC320
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and ATP-dependent activity, acting on DNA. Predicted to be involved in DNA duplex unwinding; chromatin looping; and chromatin remodeling. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 7.0), ovary (RPKM 6.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CHD9 in Genome Data Viewer
    Location:
    16q12.2
    Exon count:
    56
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (53054991..53327497)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (58852750..59125294)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (53088903..53361409)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene MTCH2 pseudogene 4 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:53078114-53078979 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:53089197-53089728 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10831 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:53094537-53094763 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10832 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10833 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10834 Neighboring gene CHD9 neighbor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10836 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:53119716-53120520 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:53125251-53125936 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:53132870-53134069 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10841 Neighboring gene MPRA-validated peak2596 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7494 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7495 Neighboring gene Sharpr-MPRA regulatory region 10980 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:53241747-53242336 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:53242337-53242924 Neighboring gene thyroid hormone receptor interactor 13 pseudogene Neighboring gene thyroid hormone receptor interactor 13 pseudogene Neighboring gene small nucleolar RNA U13 Neighboring gene RNA, 5S ribosomal pseudogene 427

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Dynamic interactions of chromatin-related mesenchymal modulator, a chromodomain helicase-DNA-binding protein, with promoters in osteoprogenitors. Shur I, et al. Stem Cells, 2006 May. PMID 16705189
    2. Characterization and functional analysis of CReMM, a novel chromodomain helicase DNA-binding protein. Shur I, et al. J Mol Biol, 2005 Sep 23. PMID 16095617
    3. Gene expression regulation by the Chromodomain helicase DNA-binding protein 9 (CHD9) chromatin remodeler is dispensable for murine development. Alendar A, et al. PLoS One, 2020. PMID 32453735, Free PMC Article
    4. Expression and regulation of CReMM, a chromodomain helicase-DNA-binding (CHD), in marrow stroma derived osteoprogenitors. Marom R, et al. J Cell Physiol, 2006 Jun. PMID 16523501
    5. PRIC320, a transcription coactivator, isolated from peroxisome proliferator-binding protein complex. Surapureddi S, et al. Biochem Biophys Res Commun, 2006 May 5. PMID 16554032

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gene expression regulation by the Chromodomain helicase DNA-binding protein 9 (CHD9) chromatin remodeler is dispensable for murine development.
      Title: Gene expression regulation by the Chromodomain helicase DNA-binding protein 9 (CHD9) chromatin remodeler is dispensable for murine development.
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    3. CReMM is a chromodomain helicase-DNA-binding protein expressed by osteoprogenitors
      Title: Expression and regulation of CReMM, a chromodomain helicase-DNA-binding (CHD), in marrow stroma derived osteoprogenitors.
    4. Chromatin immunoprecipitation assay was applied to follow the dynamics of CReMM binding to A/T-rich regions on promoters of genes that play a role in osteoblast maturation.
      Title: Dynamic interactions of chromatin-related mesenchymal modulator, a chromodomain helicase-DNA-binding protein, with promoters in osteoprogenitors.
    5. The CHD9 (CReMM) protein is extensively phosphorylated, has DNA-dependent ATPase activity, and binds to A/T-rich DNA. It is also expressed in mesenchymal progenitors.
      Title: Characterization and functional analysis of CReMM, a novel chromodomain helicase DNA-binding protein.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables forked DNA-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables four-way junction helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    chromodomain-helicase-DNA-binding protein 9
    Names
    ATP-dependent helicase CHD9
    PPAR-alpha-interacting complex protein 320 kDa
    PPAR{gamma}-interacting cofactor 320 kDa
    chromatin remodeling factor CHROM1
    chromatin-related mesenchymal modulator
    ciprofibrate bound protein p240
    kismet homolog 2
    peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein
    proteinx0008
    NP_001295248.1
    NP_001339056.1
    NP_001339085.1
    NP_001339086.1
    NP_001339087.1
    NP_001369282.1
    NP_001369283.1
    NP_001369284.1
    NP_079410.4
    XP_005256225.1
    XP_006721344.1
    XP_006721346.1
    XP_011521649.1
    XP_016879208.1
    XP_016879209.1
    XP_016879213.1
    XP_024306227.1
    XP_024306229.1
    XP_047290643.1
    XP_047290644.1
    XP_047290645.1
    XP_047290646.1
    XP_047290647.1
    XP_047290648.1
    XP_047290649.1
    XP_047290650.1
    XP_047290651.1
    XP_047290652.1
    XP_047290653.1
    XP_047290654.1
    XP_047290655.1
    XP_047290656.1
    XP_047290657.1
    XP_047290658.1
    XP_047290659.1
    XP_047290660.1
    XP_047290661.1
    XP_047290662.1
    XP_047290663.1
    XP_047290664.1
    XP_047290665.1
    XP_047290666.1
    XP_054169978.1
    XP_054169979.1
    XP_054169980.1
    XP_054169981.1
    XP_054169982.1
    XP_054169983.1
    XP_054169984.1
    XP_054169985.1
    XP_054169986.1
    XP_054169987.1
    XP_054169988.1
    XP_054169989.1
    XP_054169990.1
    XP_054169991.1
    XP_054169992.1
    XP_054169993.1
    XP_054169994.1
    XP_054169995.1
    XP_054169996.1
    XP_054169997.1
    XP_054169998.1
    XP_054169999.1
    XP_054170000.1
    XP_054170001.1
    XP_054170002.1
    XP_054170003.1
    XP_054170004.1
    XP_054170005.1
    XP_054170006.1
    XP_054170007.1
    XP_054170008.1
    XP_054170009.1
    XP_054170010.1
    XP_054170011.1
    XP_054170012.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308319.2 → NP_001295248.1  chromodomain-helicase-DNA-binding protein 9 isoform 1

      See identical proteins and their annotated locations for NP_001295248.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 7 both encode the same isoform (1).
      Source sequence(s)
      AC007906, AC079416
      Consensus CDS
      CCDS76865.1
      UniProtKB/Swiss-Prot
      B2RTU2, B9ZVQ0, O15025, Q1WF12, Q3L8U1, Q6DTK9, Q9H9V7, Q9UHM2
      UniProtKB/TrEMBL
      B7ZML1
      Related
      ENSP00000396345.2, ENST00000447540.6
      Conserved Domains (6) summary
      smart00592
      Location:2556 → 2600
      BRK; domain in transcription and CHROMO domain helicases
      PLN03142
      Location:811 → 1480
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG5422
      Location:176 → 362
      ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
      COG5641
      Location:161 → 558
      GAT1; GATA Zn-finger-containing transcription factor [Transcription]
      cd18663
      Location:770 → 828
      CD2_tandem_CHD5-9_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
      cd18668
      Location:686 → 750
      CD1_tandem_CHD5-9_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins

    2. NM_001352127.3 → NP_001339056.1  chromodomain-helicase-DNA-binding protein 9 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AC007906, AC079416
      Consensus CDS
      CCDS45485.1
      UniProtKB/TrEMBL
      B7ZML1
      Related
      ENSP00000455307.1, ENST00000564845.5
      Conserved Domains (6) summary
      smart00592
      Location:2540 → 2584
      BRK; domain in transcription and CHROMO domain helicases
      COG5048
      Location:80 → 479
      COG5048; FOG: Zn-finger [General function prediction only]
      cd00024
      Location:692 → 752
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      pfam00385
      Location:773 → 827
      Chromo; Chromo (CHRromatin Organisation MOdifier) domain
      pfam15350
      Location:164 → 355
      ETAA1; Ewing's tumor-associated antigen 1 homolog
      cl26465
      Location:811 → 1480
      SNF2_N; SNF2 family N-terminal domain

    3. NM_001352156.3 → NP_001339085.1  chromodomain-helicase-DNA-binding protein 9 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC007906, AC079416
      Consensus CDS
      CCDS92161.1
      UniProtKB/TrEMBL
      B7ZML1, H3BTW3
      Related
      ENSP00000457355.2, ENST00000565803.2
      Conserved Domains (4) summary
      smart00592
      Location:2083 → 2127
      BRK; domain in transcription and CHROMO domain helicases
      cd00024
      Location:218 → 278
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      pfam00385
      Location:299 → 353
      Chromo; Chromo (CHRromatin Organisation MOdifier) domain
      cl26465
      Location:337 → 1006
      SNF2_N; SNF2 family N-terminal domain

    4. NM_001352157.3 → NP_001339086.1  chromodomain-helicase-DNA-binding protein 9 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC007906, AC079416
      UniProtKB/TrEMBL
      Q461N2
      Conserved Domains (4) summary
      smart00592
      Location:2067 → 2111
      BRK; domain in transcription and CHROMO domain helicases
      cd00024
      Location:218 → 278
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      pfam00385
      Location:299 → 353
      Chromo; Chromo (CHRromatin Organisation MOdifier) domain
      cl26465
      Location:337 → 1006
      SNF2_N; SNF2 family N-terminal domain

    5. NM_001352158.3 → NP_001339087.1  chromodomain-helicase-DNA-binding protein 9 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC007906, AC079416
      UniProtKB/TrEMBL
      Q461N2
      Conserved Domains (4) summary
      smart00592
      Location:2034 → 2078
      BRK; domain in transcription and CHROMO domain helicases
      cd00024
      Location:185 → 245
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      pfam00385
      Location:266 → 320
      Chromo; Chromo (CHRromatin Organisation MOdifier) domain
      cl26465
      Location:304 → 973
      SNF2_N; SNF2 family N-terminal domain

    6. NM_001382353.1 → NP_001369282.1  chromodomain-helicase-DNA-binding protein 9 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variant 1, encodes isoform 1.
      Source sequence(s)
      AC007906, AC079416
      Consensus CDS
      CCDS76865.1
      UniProtKB/Swiss-Prot
      B2RTU2, B9ZVQ0, O15025, Q1WF12, Q3L8U1, Q6DTK9, Q9H9V7, Q9UHM2
      UniProtKB/TrEMBL
      B7ZML1
      Related
      ENSP00000381522.3, ENST00000398510.7
      Conserved Domains (6) summary
      smart00592
      Location:2556 → 2600
      BRK; domain in transcription and CHROMO domain helicases
      PLN03142
      Location:811 → 1480
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG5422
      Location:176 → 362
      ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
      COG5641
      Location:161 → 558
      GAT1; GATA Zn-finger-containing transcription factor [Transcription]
      cd18663
      Location:770 → 828
      CD2_tandem_CHD5-9_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
      cd18668
      Location:686 → 750
      CD1_tandem_CHD5-9_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins

    7. NM_001382354.1 → NP_001369283.1  chromodomain-helicase-DNA-binding protein 9 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC007906, AC079416
      UniProtKB/TrEMBL
      Q461N2
      Conserved Domains (5) summary
      smart00592
      Location:2050 → 2094
      BRK; domain in transcription and CHROMO domain helicases
      PLN03142
      Location:304 → 973
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      cd18663
      Location:263 → 321
      CD2_tandem_CHD5-9_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
      cd18668
      Location:179 → 243
      CD1_tandem_CHD5-9_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
      cd18061
      Location:353 → 574
      DEXHc_CHD9; DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9

    8. NM_001382355.1 → NP_001369284.1  chromodomain-helicase-DNA-binding protein 9 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC007906, AC079416
      UniProtKB/TrEMBL
      Q461N2
      Conserved Domains (5) summary
      smart00592
      Location:2049 → 2093
      BRK; domain in transcription and CHROMO domain helicases
      PLN03142
      Location:304 → 973
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      cd18663
      Location:263 → 321
      CD2_tandem_CHD5-9_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
      cd18668
      Location:179 → 243
      CD1_tandem_CHD5-9_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
      cd18061
      Location:353 → 574
      DEXHc_CHD9; DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9

    9. NM_025134.7 → NP_079410.4  chromodomain-helicase-DNA-binding protein 9 isoform 2

      See identical proteins and their annotated locations for NP_079410.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variant 3, encodes isoform 2.
      Source sequence(s)
      AC007906, AC079416
      Consensus CDS
      CCDS45485.1
      UniProtKB/TrEMBL
      B7ZML1
      Related
      ENSP00000457466.1, ENST00000566029.5
      Conserved Domains (6) summary
      smart00592
      Location:2540 → 2584
      BRK; domain in transcription and CHROMO domain helicases
      COG5048
      Location:80 → 479
      COG5048; FOG: Zn-finger [General function prediction only]
      cd00024
      Location:692 → 752
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      pfam00385
      Location:773 → 827
      Chromo; Chromo (CHRromatin Organisation MOdifier) domain
      pfam15350
      Location:164 → 355
      ETAA1; Ewing's tumor-associated antigen 1 homolog
      cl26465
      Location:811 → 1480
      SNF2_N; SNF2 family N-terminal domain

    RNA

    1. NR_168108.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007906

    2. NR_168109.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007906

    3. NR_168111.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007906

    4. NR_168112.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007906

    5. NR_168114.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007906

    6. NR_168116.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007906

    7. NR_168117.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007906

    8. NR_168119.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007906

    9. NR_168120.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007906

    10. NR_168123.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007906

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      53054991..53327497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434707.1 → XP_047290663.1  chromodomain-helicase-DNA-binding protein 9 isoform X7

      UniProtKB/TrEMBL
      B7ZML1

    2. XM_047434693.1 → XP_047290649.1  chromodomain-helicase-DNA-binding protein 9 isoform X2

      UniProtKB/Swiss-Prot
      B2RTU2, B9ZVQ0, O15025, Q1WF12, Q3L8U1, Q6DTK9, Q9H9V7, Q9UHM2
      UniProtKB/TrEMBL
      B7ZML1

    3. XM_047434692.1 → XP_047290648.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      UniProtKB/TrEMBL
      B7ZML1

    4. XM_017023719.2 → XP_016879208.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      UniProtKB/TrEMBL
      B7ZML1
      Conserved Domains (6) summary
      smart00592
      Location:2557 → 2601
      BRK; domain in transcription and CHROMO domain helicases
      COG5048
      Location:80 → 479
      COG5048; FOG: Zn-finger [General function prediction only]
      cd00024
      Location:692 → 752
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      pfam00385
      Location:773 → 827
      Chromo; Chromo (CHRromatin Organisation MOdifier) domain
      pfam15350
      Location:164 → 355
      ETAA1; Ewing's tumor-associated antigen 1 homolog
      cl26465
      Location:811 → 1480
      SNF2_N; SNF2 family N-terminal domain

    5. XM_047434703.1 → XP_047290659.1  chromodomain-helicase-DNA-binding protein 9 isoform X7

      UniProtKB/TrEMBL
      B7ZML1

    6. XM_017023720.2 → XP_016879209.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      UniProtKB/TrEMBL
      B7ZML1
      Conserved Domains (6) summary
      smart00592
      Location:2557 → 2601
      BRK; domain in transcription and CHROMO domain helicases
      COG5048
      Location:80 → 479
      COG5048; FOG: Zn-finger [General function prediction only]
      cd00024
      Location:692 → 752
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      pfam00385
      Location:773 → 827
      Chromo; Chromo (CHRromatin Organisation MOdifier) domain
      pfam15350
      Location:164 → 355
      ETAA1; Ewing's tumor-associated antigen 1 homolog
      cl26465
      Location:811 → 1480
      SNF2_N; SNF2 family N-terminal domain

    7. XM_047434699.1 → XP_047290655.1  chromodomain-helicase-DNA-binding protein 9 isoform X7

      UniProtKB/TrEMBL
      B7ZML1

    8. XM_024450459.2 → XP_024306227.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      UniProtKB/TrEMBL
      B7ZML1
      Conserved Domains (6) summary
      smart00592
      Location:2557 → 2601
      BRK; domain in transcription and CHROMO domain helicases
      COG5048
      Location:80 → 479
      COG5048; FOG: Zn-finger [General function prediction only]
      cd00024
      Location:692 → 752
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      pfam00385
      Location:773 → 827
      Chromo; Chromo (CHRromatin Organisation MOdifier) domain
      pfam15350
      Location:164 → 355
      ETAA1; Ewing's tumor-associated antigen 1 homolog
      cl26465
      Location:811 → 1480
      SNF2_N; SNF2 family N-terminal domain

    9. XM_047434695.1 → XP_047290651.1  chromodomain-helicase-DNA-binding protein 9 isoform X3

      UniProtKB/TrEMBL
      B7ZML1

    10. XM_047434700.1 → XP_047290656.1  chromodomain-helicase-DNA-binding protein 9 isoform X7

      UniProtKB/TrEMBL
      B7ZML1

    11. XM_005256168.5 → XP_005256225.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      See identical proteins and their annotated locations for XP_005256225.1

      UniProtKB/TrEMBL
      B7ZML1
      Conserved Domains (6) summary
      smart00592
      Location:2557 → 2601
      BRK; domain in transcription and CHROMO domain helicases
      COG5048
      Location:80 → 479
      COG5048; FOG: Zn-finger [General function prediction only]
      cd00024
      Location:692 → 752
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      pfam00385
      Location:773 → 827
      Chromo; Chromo (CHRromatin Organisation MOdifier) domain
      pfam15350
      Location:164 → 355
      ETAA1; Ewing's tumor-associated antigen 1 homolog
      cl26465
      Location:811 → 1480
      SNF2_N; SNF2 family N-terminal domain

    12. XM_047434694.1 → XP_047290650.1  chromodomain-helicase-DNA-binding protein 9 isoform X3

      UniProtKB/TrEMBL
      B7ZML1

    13. XM_047434696.1 → XP_047290652.1  chromodomain-helicase-DNA-binding protein 9 isoform X4

      UniProtKB/TrEMBL
      B7ZML1

    14. XM_047434697.1 → XP_047290653.1  chromodomain-helicase-DNA-binding protein 9 isoform X5

      UniProtKB/TrEMBL
      B7ZML1

    15. XM_047434698.1 → XP_047290654.1  chromodomain-helicase-DNA-binding protein 9 isoform X6

      UniProtKB/TrEMBL
      B7ZML1

    16. XM_047434702.1 → XP_047290658.1  chromodomain-helicase-DNA-binding protein 9 isoform X7

      UniProtKB/TrEMBL
      B7ZML1

    17. XM_047434688.1 → XP_047290644.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      UniProtKB/TrEMBL
      B7ZML1

    18. XM_047434706.1 → XP_047290662.1  chromodomain-helicase-DNA-binding protein 9 isoform X7

      UniProtKB/TrEMBL
      B7ZML1

    19. XM_047434689.1 → XP_047290645.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      UniProtKB/TrEMBL
      B7ZML1

    20. XM_047434690.1 → XP_047290646.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      UniProtKB/TrEMBL
      B7ZML1

    21. XM_047434701.1 → XP_047290657.1  chromodomain-helicase-DNA-binding protein 9 isoform X7

      UniProtKB/TrEMBL
      B7ZML1

    22. XM_006721283.4 → XP_006721346.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      See identical proteins and their annotated locations for XP_006721346.1

      UniProtKB/TrEMBL
      B7ZML1
      Conserved Domains (6) summary
      smart00592
      Location:2557 → 2601
      BRK; domain in transcription and CHROMO domain helicases
      COG5048
      Location:80 → 479
      COG5048; FOG: Zn-finger [General function prediction only]
      cd00024
      Location:692 → 752
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      pfam00385
      Location:773 → 827
      Chromo; Chromo (CHRromatin Organisation MOdifier) domain
      pfam15350
      Location:164 → 355
      ETAA1; Ewing's tumor-associated antigen 1 homolog
      cl26465
      Location:811 → 1480
      SNF2_N; SNF2 family N-terminal domain

    23. XM_047434704.1 → XP_047290660.1  chromodomain-helicase-DNA-binding protein 9 isoform X7

      UniProtKB/TrEMBL
      B7ZML1

    24. XM_047434687.1 → XP_047290643.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      UniProtKB/TrEMBL
      B7ZML1

    25. XM_047434705.1 → XP_047290661.1  chromodomain-helicase-DNA-binding protein 9 isoform X7

      UniProtKB/TrEMBL
      B7ZML1

    26. XM_011523347.3 → XP_011521649.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      See identical proteins and their annotated locations for XP_011521649.1

      UniProtKB/TrEMBL
      B7ZML1
      Conserved Domains (6) summary
      smart00592
      Location:2557 → 2601
      BRK; domain in transcription and CHROMO domain helicases
      COG5048
      Location:80 → 479
      COG5048; FOG: Zn-finger [General function prediction only]
      cd00024
      Location:692 → 752
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      pfam00385
      Location:773 → 827
      Chromo; Chromo (CHRromatin Organisation MOdifier) domain
      pfam15350
      Location:164 → 355
      ETAA1; Ewing's tumor-associated antigen 1 homolog
      cl26465
      Location:811 → 1480
      SNF2_N; SNF2 family N-terminal domain

    27. XM_017023724.2 → XP_016879213.1  chromodomain-helicase-DNA-binding protein 9 isoform X7

      UniProtKB/TrEMBL
      B7ZML1
      Conserved Domains (6) summary
      smart00592
      Location:2106 → 2150
      BRK; domain in transcription and CHROMO domain helicases
      cd00024
      Location:241 → 301
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00046
      Location:428 → 577
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:412 → 699
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:731 → 845
      Helicase_C; Helicase conserved C-terminal domain
      pfam00385
      Location:323 → 376
      Chromo; Chromo (CHRromatin Organization MOdifier) domain

    28. XM_006721281.3 → XP_006721344.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      See identical proteins and their annotated locations for XP_006721344.1

      UniProtKB/TrEMBL
      B7ZML1
      Conserved Domains (6) summary
      smart00592
      Location:2557 → 2601
      BRK; domain in transcription and CHROMO domain helicases
      COG5048
      Location:80 → 479
      COG5048; FOG: Zn-finger [General function prediction only]
      cd00024
      Location:692 → 752
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      pfam00385
      Location:773 → 827
      Chromo; Chromo (CHRromatin Organisation MOdifier) domain
      pfam15350
      Location:164 → 355
      ETAA1; Ewing's tumor-associated antigen 1 homolog
      cl26465
      Location:811 → 1480
      SNF2_N; SNF2 family N-terminal domain

    29. XM_047434691.1 → XP_047290647.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      UniProtKB/TrEMBL
      B7ZML1

    30. XM_047434709.1 → XP_047290665.1  chromodomain-helicase-DNA-binding protein 9 isoform X9

      UniProtKB/TrEMBL
      Q461N2

    31. XM_047434710.1 → XP_047290666.1  chromodomain-helicase-DNA-binding protein 9 isoform X10

      UniProtKB/TrEMBL
      Q461N2

    32. XM_047434708.1 → XP_047290664.1  chromodomain-helicase-DNA-binding protein 9 isoform X8

      UniProtKB/TrEMBL
      B7ZML1

    33. XM_024450461.2 → XP_024306229.1  chromodomain-helicase-DNA-binding protein 9 isoform X11

      UniProtKB/TrEMBL
      Q461N2
      Related
      ENST00000219084.10
      Conserved Domains (4) summary
      smart00592
      Location:1896 → 1940
      BRK; domain in transcription and CHROMO domain helicases
      cd00024
      Location:31 → 91
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      pfam00385
      Location:112 → 166
      Chromo; Chromo (CHRromatin Organisation MOdifier) domain
      cl26465
      Location:150 → 819
      SNF2_N; SNF2 family N-terminal domain

    RNA

    1. XR_007064921.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      58852750..59125294
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314033.1 → XP_054170008.1  chromodomain-helicase-DNA-binding protein 9 isoform X7

      UniProtKB/TrEMBL
      B7ZML1

    2. XM_054314017.1 → XP_054169992.1  chromodomain-helicase-DNA-binding protein 9 isoform X2

      UniProtKB/TrEMBL
      B7ZML1

    3. XM_054314016.1 → XP_054169991.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      UniProtKB/TrEMBL
      B7ZML1

    4. XM_054314008.1 → XP_054169983.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      UniProtKB/TrEMBL
      B7ZML1

    5. XM_054314029.1 → XP_054170004.1  chromodomain-helicase-DNA-binding protein 9 isoform X7

      UniProtKB/TrEMBL
      B7ZML1

    6. XM_054314009.1 → XP_054169984.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      UniProtKB/TrEMBL
      B7ZML1

    7. XM_054314024.1 → XP_054169999.1  chromodomain-helicase-DNA-binding protein 9 isoform X7

      UniProtKB/TrEMBL
      B7ZML1

    8. XM_054314011.1 → XP_054169986.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      UniProtKB/TrEMBL
      B7ZML1

    9. XM_054314019.1 → XP_054169994.1  chromodomain-helicase-DNA-binding protein 9 isoform X3

      UniProtKB/TrEMBL
      B7ZML1

    10. XM_054314025.1 → XP_054170000.1  chromodomain-helicase-DNA-binding protein 9 isoform X7

      UniProtKB/TrEMBL
      B7ZML1

    11. XM_054314003.1 → XP_054169978.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      UniProtKB/TrEMBL
      B7ZML1

    12. XM_054314018.1 → XP_054169993.1  chromodomain-helicase-DNA-binding protein 9 isoform X3

      UniProtKB/TrEMBL
      B7ZML1

    13. XM_054314020.1 → XP_054169995.1  chromodomain-helicase-DNA-binding protein 9 isoform X4

      UniProtKB/TrEMBL
      B7ZML1

    14. XM_054314021.1 → XP_054169996.1  chromodomain-helicase-DNA-binding protein 9 isoform X5

      UniProtKB/TrEMBL
      B7ZML1

    15. XM_054314022.1 → XP_054169997.1  chromodomain-helicase-DNA-binding protein 9 isoform X6

      UniProtKB/TrEMBL
      B7ZML1

    16. XM_054314030.1 → XP_054170005.1  chromodomain-helicase-DNA-binding protein 9 isoform X7

      UniProtKB/TrEMBL
      B7ZML1

    17. XM_054314007.1 → XP_054169982.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      UniProtKB/TrEMBL
      B7ZML1

    18. XM_054314031.1 → XP_054170006.1  chromodomain-helicase-DNA-binding protein 9 isoform X7

      UniProtKB/TrEMBL
      B7ZML1

    19. XM_054314010.1 → XP_054169985.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      UniProtKB/TrEMBL
      B7ZML1

    20. XM_054314026.1 → XP_054170001.1  chromodomain-helicase-DNA-binding protein 9 isoform X7

      UniProtKB/TrEMBL
      B7ZML1

    21. XM_054314006.1 → XP_054169981.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      UniProtKB/TrEMBL
      B7ZML1

    22. XM_054314027.1 → XP_054170002.1  chromodomain-helicase-DNA-binding protein 9 isoform X7

      UniProtKB/TrEMBL
      B7ZML1

    23. XM_054314005.1 → XP_054169980.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      UniProtKB/TrEMBL
      B7ZML1

    24. XM_054314012.1 → XP_054169987.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      UniProtKB/TrEMBL
      B7ZML1

    25. XM_054314014.1 → XP_054169989.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      UniProtKB/TrEMBL
      B7ZML1

    26. XM_054314015.1 → XP_054169990.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      UniProtKB/TrEMBL
      B7ZML1

    27. XM_054314032.1 → XP_054170007.1  chromodomain-helicase-DNA-binding protein 9 isoform X7

      UniProtKB/TrEMBL
      B7ZML1

    28. XM_054314028.1 → XP_054170003.1  chromodomain-helicase-DNA-binding protein 9 isoform X7

      UniProtKB/TrEMBL
      B7ZML1

    29. XM_054314013.1 → XP_054169988.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      UniProtKB/TrEMBL
      B7ZML1

    30. XM_054314035.1 → XP_054170010.1  chromodomain-helicase-DNA-binding protein 9 isoform X9

      UniProtKB/TrEMBL
      Q461N2

    31. XM_054314036.1 → XP_054170011.1  chromodomain-helicase-DNA-binding protein 9 isoform X10

      UniProtKB/TrEMBL
      Q461N2

    32. XM_054314034.1 → XP_054170009.1  chromodomain-helicase-DNA-binding protein 9 isoform X8

      UniProtKB/TrEMBL
      B7ZML1

    33. XM_054314023.1 → XP_054169998.1  chromodomain-helicase-DNA-binding protein 9 isoform X7

      UniProtKB/TrEMBL
      B7ZML1

    34. XM_054314004.1 → XP_054169979.1  chromodomain-helicase-DNA-binding protein 9 isoform X1

      UniProtKB/TrEMBL
      B7ZML1

    35. XM_054314037.1 → XP_054170012.1  chromodomain-helicase-DNA-binding protein 9 isoform X11

      UniProtKB/TrEMBL
      Q461N2

    RNA

    1. XR_008484740.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_015287.1: Suppressed sequence

      Description
      NM_015287.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3L8U1.2 GenPept UniProtKB/Swiss-Prot:Q3L8U1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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