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    CRTC2 CREB regulated transcription coactivator 2 [ Homo sapiens (human) ]

    Gene ID: 200186, updated on 10-Dec-2024

    Summary

    Official Symbol
    CRTC2provided by HGNC
    Official Full Name
    CREB regulated transcription coactivator 2provided by HGNC
    Primary source
    HGNC:HGNC:27301
    See related
    Ensembl:ENSG00000160741 MIM:608972; AllianceGenome:HGNC:27301
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TORC2; TORC-2
    Summary
    This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010]
    Expression
    Ubiquitous expression in spleen (RPKM 17.9), bone marrow (RPKM 17.3) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CRTC2 in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (153947675..153958612, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (153084936..153095873, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153920151..153931088, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene GATA zinc finger domain containing 2B Neighboring gene adipose differentiation-related protein pseudogene Neighboring gene Sharpr-MPRA regulatory region 14566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153877149-153877650 Neighboring gene Sharpr-MPRA regulatory region 2699 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1755 Neighboring gene uncharacterized LOC101928059 Neighboring gene Sharpr-MPRA regulatory region 4321 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:153897582-153897755 Neighboring gene DENN domain containing 4B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1757 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:153918384-153918884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1760 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1762 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:153935601-153936800 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:153939664-153940520 Neighboring gene solute carrier family 39 member 1 Neighboring gene microRNA 6737 Neighboring gene cAMP responsive element binding protein 3 like 4 Neighboring gene jumping translocation breakpoint

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of CREB regulated transcription coactivator 2 (CRTC2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cAMP response element binding protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to cAMP IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of CREB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    CREB-regulated transcription coactivator 2
    Names
    transducer of regulated cAMP response element-binding protein (CREB) 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181715.3NP_859066.1  CREB-regulated transcription coactivator 2

      See identical proteins and their annotated locations for NP_859066.1

      Status: REVIEWED

      Source sequence(s)
      AY360172, AY726597, BC053562, BM987537
      Consensus CDS
      CCDS30875.1
      UniProtKB/Swiss-Prot
      Q53ET0, Q6UUV8, Q7Z3X7, Q8N332
      Related
      ENSP00000357622.1, ENST00000368633.2
      Conserved Domains (3) summary
      pfam12884
      Location:1872
      TORC_N; Transducer of regulated CREB activity, N terminus
      pfam12885
      Location:168320
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:615692
      TORC_C; Transducer of regulated CREB activity, C terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      153947675..153958612 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017000577.2XP_016856066.1  CREB-regulated transcription coactivator 2 isoform X4

    2. XM_005244946.2XP_005245003.1  CREB-regulated transcription coactivator 2 isoform X1

      Related
      ENST00000487235.5
      Conserved Domains (3) summary
      pfam12884
      Location:1872
      TORC_N; Transducer of regulated CREB activity, N terminus
      pfam12885
      Location:168325
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:620697
      TORC_C; Transducer of regulated CREB activity, C terminus
    3. XM_017000576.1XP_016856065.1  CREB-regulated transcription coactivator 2 isoform X3

    4. XM_017000575.1XP_016856064.1  CREB-regulated transcription coactivator 2 isoform X2

    5. XM_017000579.2XP_016856068.1  CREB-regulated transcription coactivator 2 isoform X5

    6. XM_047448820.1XP_047304776.1  CREB-regulated transcription coactivator 2 isoform X6

    7. XM_047448823.1XP_047304779.1  CREB-regulated transcription coactivator 2 isoform X7

    RNA

    1. XR_007095721.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      153084936..153095873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334981.1XP_054190956.1  CREB-regulated transcription coactivator 2 isoform X4

    2. XM_054334978.1XP_054190953.1  CREB-regulated transcription coactivator 2 isoform X1

    3. XM_054334980.1XP_054190955.1  CREB-regulated transcription coactivator 2 isoform X3

    4. XM_054334979.1XP_054190954.1  CREB-regulated transcription coactivator 2 isoform X2

    5. XM_054334982.1XP_054190957.1  CREB-regulated transcription coactivator 2 isoform X5

    6. XM_054334983.1XP_054190958.1  CREB-regulated transcription coactivator 2 isoform X6

    7. XM_054334984.1XP_054190959.1  CREB-regulated transcription coactivator 2 isoform X7

    RNA

    1. XR_008485960.1 RNA Sequence