AS3MT arsenite methyltransferase [Homo sapiens (human)] - Gene

Summary

Official Symbol: AS3MTprovided by HGNC
Official Full Name: arsenite methyltransferaseprovided by HGNC
Primary source: HGNC:HGNC:17452
See related: Ensembl:ENSG00000214435 MIM:611806; AllianceGenome:HGNC:17452
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CYT19
Summary: AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008]
Expression: Biased expression in adrenal (RPKM 88.8), liver (RPKM 11.0) and 5 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q24.32

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (102869470..102901899)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (103755254..103787669)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (104629227..104661656)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association between arsenic (+3 oxidation state) methyltransferase gene polymorphisms and arsenic methylation capacity in rural residents of northern China: a cross-sectional study.
Title: Association between arsenic (+3 oxidation state) methyltransferase gene polymorphisms and arsenic methylation capacity in rural residents of northern China: a cross-sectional study.
AS3MT facilitates NLRP3 inflammasome activation by m[6]A modification during arsenic-induced hepatic insulin resistance.
Title: AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance.
As3MT is related to relative RNAs and base modifications of p53 in workers exposed to arsenic.
Title: As3MT is related to relative RNAs and base modifications of p53 in workers exposed to arsenic.
Arsenic metabolism, N6AMT1 and AS3MT single nucleotide polymorphisms, and their interaction on gestational diabetes mellitus in Chinese pregnant women.
Title: Arsenic metabolism, N6AMT1 and AS3MT single nucleotide polymorphisms, and their interaction on gestational diabetes mellitus in Chinese pregnant women.
Functional characterization of the schizophrenia associated gene AS3MT identifies a role in neuronal development.
Title: Functional characterization of the schizophrenia associated gene AS3MT identifies a role in neuronal development.
Single molecule in situ hybridization reveals distinct localizations of schizophrenia risk-related transcripts SNX19 and AS3MT in human brain.
Title: Single molecule in situ hybridization reveals distinct localizations of schizophrenia risk-related transcripts SNX19 and AS3MT in human brain.
Association between the polymorphism of three genes involved in the methylation and efflux of arsenic (As3MT, MRP1, and P-gp) with lung cancer in a Mexican cohort.
Title: Association between the polymorphism of three genes involved in the methylation and efflux of arsenic (As3MT, MRP1, and P-gp) with lung cancer in a Mexican cohort.
The VNTR of the AS3MT gene is associated with brain activations during a memory span task and their training-induced plasticity.
Title: The VNTR of the AS3MT gene is associated with brain activations during a memory span task and their training-induced plasticity.
A Human-Specific Schizophrenia Risk Tandem Repeat Affects Alternative Splicing of a Human-Unique Isoform AS3MTd2d3 and Mushroom Dendritic Spine Density.
Title: A Human-Specific Schizophrenia Risk Tandem Repeat Affects Alternative Splicing of a Human-Unique Isoform AS3MTd2d3 and Mushroom Dendritic Spine Density.
Arsenic Methyltransferase and Methylation of Inorganic Arsenic.
Title: Arsenic Methyltransferase and Methylation of Inorganic Arsenic.

Submit: New GeneRIF Correction See all GeneRIFs (82)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A comprehensive family-based replication study of schizophrenia genes. EBI GWAS Catalog EBI GWAS CatalogPubMed
Biological insights from 108 schizophrenia-associated genetic loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association analysis identifies 13 new risk loci for schizophrenia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies chromosome 10q24.32 variants associated with arsenic metabolism and toxicity phenotypes in Bangladesh. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies eight loci associated with blood pressure. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D16S779 (e-PCR)
- UniSTS:65821

D8S2278 (e-PCR)
- UniSTS:473906

D8S2279 (e-PCR)
- UniSTS:473907

MARC_17614-17615:1019141787:1 (e-PCR)
- UniSTS:268356

STS-N70305 (e-PCR)
- UniSTS:80210

RH36905 (e-PCR)
- UniSTS:87932

RH44877 (e-PCR)
- UniSTS:12678

D11S3114 (e-PCR)
- UniSTS:152207

MARC_14453-14454:1010434240:1 (e-PCR)
- UniSTS:267675

GDB:631802 (e-PCR)
- UniSTS:158429

Readthrough BORCS7-ASMT

Readthrough gene: BORCS7-ASMT, Included gene: BORCS7

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables arsenite methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arsenite methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables arsenite methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables arsenite methyltransferase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in arsonoacetate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in arsonoacetate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in methylation	IDA Inferred from Direct Assay more info	PubMed
involved_in methylation	TAS Traceable Author Statement more info
involved_in toxin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in toxin metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: arsenite methyltransferase

Names: S-adenosyl-L-methionine:arsenic(III) methyltransferase; S-adenosylmethionine:arsenic (III) methyltransferase; arsenic (+3 oxidation state) methyltransferase; methylarsonite methyltransferase; methyltransferase cyt19

NP_065733.2

EC 2.1.1.137

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.