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    ATP2B1 ATPase plasma membrane Ca2+ transporting 1 [ Homo sapiens (human) ]

    Gene ID: 490, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ATP2B1provided by HGNC
    Official Full Name
    ATPase plasma membrane Ca2+ transporting 1provided by HGNC
    Primary source
    HGNC:HGNC:814
    See related
    Ensembl:ENSG00000070961 MIM:108731; AllianceGenome:HGNC:814
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRD66; PMCA1; PMCA1kb
    Summary
    The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 34.3), bone marrow (RPKM 16.4) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ATP2B1 in Genome Data Viewer
    Location:
    12q21.33
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (89588049..89709366, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (89569850..89691243, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (89981826..90103143, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene POC1 centriolar protein B Neighboring gene POC1B-GALNT4 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4694 Neighboring gene POC1B antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4695 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4697 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4698 Neighboring gene uncharacterized LOC107984543 Neighboring gene ATP2B1 antisense RNA 1 Neighboring gene RNA, 5S ribosomal pseudogene 365 Neighboring gene mitochondrial ribosomal protein L2 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Deletions in the A(L) region of the h4xb plasma membrane Ca(2+) pump. High apparent affinity for Ca(2+) of a deletion mutant resembling the alternative spliced form h4zb. de Tezanos Pinto F, et al. FEBS Lett, 2006 Mar 6. PMID 16488415
    2. Common variants in the ATP2B1 gene are associated with hypertension and arterial stiffness in Chinese population. Wang Y, et al. Mol Biol Rep, 2013 Feb. PMID 23079715
    3. Expression, purification, and characterization of isoform 1 of the plasma membrane Ca2+ pump: focus on calpain sensitivity. Guerini D, et al. J Biol Chem, 2003 Oct 3. PMID 12851406
    4. Polymorphism near the ATP2B1 gene is associated with hypertension risk in East Asians: a meta-analysis involving 15 909 cases and 18 529 controls. Xi B, et al. Blood Press, 2012 Apr. PMID 22229515
    5. De novo variants in ATP2B1 lead to neurodevelopmental delay. Rahimi MJ, et al. Am J Hum Genet, 2022 May 5. PMID 35358416, Free PMC Article

    See all (197) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ATP2B1 gene polymorphisms associated with resistant hypertension in the Japanese population.
      Title: ATP2B1 gene polymorphisms associated with resistant hypertension in the Japanese population.
    2. Association between polymorphism and haplotype of ATP2B1 gene and skeletal fluorosis in Han population.
      Title: Association between polymorphism and haplotype of ATP2B1 gene and skeletal fluorosis in Han population.
    3. The Plasma Membrane Ca[2+]-ATPase, a Molecular Target for Tau-induced Cytosolic Calcium Dysregulation.
      Title: The Plasma Membrane Ca(2+)-ATPase, a Molecular Target for Tau-induced Cytosolic Calcium Dysregulation.
    4. ATP2B1-AS1 exacerbates sepsis-induced cell apoptosis and inflammation by regulating miR-23a-3p/TLR4 axis.
      Title: ATP2B1-AS1 exacerbates sepsis-induced cell apoptosis and inflammation by regulating miR-23a-3p/TLR4 axis.
    5. Re-wiring and gene expression changes of AC025034.1 and ATP2B1 play complex roles in early-to-late breast cancer progression.
      Title: Re-wiring and gene expression changes of AC025034.1 and ATP2B1 play complex roles in early-to-late breast cancer progression.
    6. De novo variants in ATP2B1 lead to neurodevelopmental delay.
      Title: De novo variants in ATP2B1 lead to neurodevelopmental delay.
    7. ATP2B1 gene rs71454161, rs73196661 and rs73196675 polymorphisms in eclampsia.
      Title: ATP2B1 gene rs71454161, rs73196661 and rs73196675 polymorphisms in eclampsia.
    8. ATP2B1 genotypes rs2070759 and rs2681472 polymorphisms and risk of hypertension in Saudi population.
      Title: ATP2B1 genotypes rs2070759 and rs2681472 polymorphisms and risk of hypertension in Saudi population.
    9. Plasma membrane calcium ATPase 1 regulates human umbilical vein endothelial cell angiogenesis and viability.
      Title: Plasma membrane calcium ATPase 1 regulates human umbilical vein endothelial cell angiogenesis and viability.
    10. Sorcin Activates the Brain PMCA and Blocks the Inhibitory Effects of Molecular Markers of Alzheimer's Disease on the Pump Activity.
      Title: Sorcin Activates the Brain PMCA and Blocks the Inhibitory Effects of Molecular Markers of Alzheimer's Disease on the Pump Activity.
    Submit: New GeneRIF Correction See all GeneRIFs (59)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Intellectual developmental disorder, autosomal dominant 66
    MedGen: C5677000 OMIM: 619910 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.
    EBI GWAS Catalog
    Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
    EBI GWAS Catalog
    Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels.
    EBI GWAS Catalog
    Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
    EBI GWAS Catalog
    Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
    EBI GWAS Catalog
    Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.
    EBI GWAS Catalog
    Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci.
    EBI GWAS Catalog
    Genome-wide association study of blood pressure and hypertension.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu HIV-1 Vpu is identified to have a physical interaction with ATPase, Ca++ transporting, plasma membrane 1 (ATP2B1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables P-type calcium transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type calcium transporter activity TAS
    Traceable Author Statement
    more info
    		  
    enables calcium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular function inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion export across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport TAS
    Traceable Author Statement
    more info
    		  
    involved_in negative regulation of cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cytosolic calcium ion concentration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of bone mineralization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of blood pressure ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cardiac conduction TAS
    Traceable Author Statement
    more info
    		  
    involved_in regulation of cellular response to insulin stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of vascular associated smooth muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in immunological synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in photoreceptor ribbon synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in presynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in synaptic vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    plasma membrane calcium-transporting ATPase 1
    Names
    ATPase, Ca++ transporting, plasma membrane 1
    plasma membrane calcium pump
    NP_001001323.1
    NP_001353449.1
    NP_001353450.1
    NP_001353451.1
    NP_001353452.1
    NP_001353453.1
    NP_001353454.1
    NP_001353455.1
    NP_001353456.1
    NP_001353457.1
    NP_001353458.1
    NP_001353459.1
    NP_001353460.1
    NP_001353461.1
    NP_001399975.1
    NP_001399976.1
    NP_001399977.1
    NP_001399978.1
    NP_001399979.1
    NP_001399980.1
    NP_001399981.1
    NP_001399982.1
    NP_001399983.1
    NP_001399984.1
    NP_001399985.1
    NP_001399986.1
    NP_001399987.1
    NP_001399988.1
    NP_001399989.1
    NP_001673.2
    XP_016874846.1
    XP_024304761.1
    XP_047284845.1
    XP_047284846.1
    XP_047284847.1
    XP_047284848.1
    XP_047284849.1
    XP_047284850.1
    XP_047284852.1
    XP_047284853.1
    XP_047284854.1
    XP_047284856.1
    XP_054228102.1
    XP_054228103.1
    XP_054228104.1
    XP_054228105.1
    XP_054228106.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029485.2 RefSeqGene

      Range
      5516..126305
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001001323.2 → NP_001001323.1  plasma membrane calcium-transporting ATPase 1 isoform 1a

      See identical proteins and their annotated locations for NP_001001323.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), as well as variant 6, encodes isoform 1a, also known as hPMCA1a.
      Source sequence(s)
      AC009522, AC025034, AC068641
      Consensus CDS
      CCDS41817.1
      UniProtKB/Swiss-Prot
      P20020
      Related
      ENSP00000447041.2, ENST00000551310.2
      Conserved Domains (2) summary
      TIGR01517
      Location:15 → 1064
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1103 → 1142
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    2. NM_001366520.1 → NP_001353449.1  plasma membrane calcium-transporting ATPase 1 isoform 1b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variants 2, 4, 5, 16, and 17, encodes isoform 1b.
      Source sequence(s)
      AC009522, AC025034, AC068641
      Consensus CDS
      CCDS9035.1
      UniProtKB/Swiss-Prot
      P20020, Q12992, Q12993, Q13819, Q13820, Q13821, Q16504, Q93082
      Conserved Domains (2) summary
      TIGR01517
      Location:15 → 1064
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1103 → 1149
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    3. NM_001366521.1 → NP_001353450.1  plasma membrane calcium-transporting ATPase 1 isoform 1b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 2, 3, 5, 16, and 17, encodes isoform 1b.
      Source sequence(s)
      AC009522, AC025034, AC068641
      Consensus CDS
      CCDS9035.1
      UniProtKB/Swiss-Prot
      P20020, Q12992, Q12993, Q13819, Q13820, Q13821, Q16504, Q93082
      Related
      ENSP00000392043.3, ENST00000428670.8
      Conserved Domains (2) summary
      TIGR01517
      Location:15 → 1064
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1103 → 1149
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    4. NM_001366522.1 → NP_001353451.1  plasma membrane calcium-transporting ATPase 1 isoform 1b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 2-4, 16, and 17, encodes isoform 1b.
      Source sequence(s)
      AC009522, AC025034, AC068641
      Consensus CDS
      CCDS9035.1
      UniProtKB/Swiss-Prot
      P20020, Q12992, Q12993, Q13819, Q13820, Q13821, Q16504, Q93082
      Conserved Domains (2) summary
      TIGR01517
      Location:15 → 1064
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1103 → 1149
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    5. NM_001366523.1 → NP_001353452.1  plasma membrane calcium-transporting ATPase 1 isoform 1a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variant 1, encodes isoform 1a.
      Source sequence(s)
      AC009522, AC025034, AC068641
      Consensus CDS
      CCDS41817.1
      Related
      ENSP00000352054.3, ENST00000359142.8
      Conserved Domains (2) summary
      TIGR01517
      Location:15 → 1064
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1103 → 1142
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    6. NM_001366524.1 → NP_001353453.1  plasma membrane calcium-transporting ATPase 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variant 8, encodes isoform 2.
      Source sequence(s)
      AC009522, AC025034, AC068641
      Conserved Domains (2) summary
      TIGR01517
      Location:15 → 1064
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1103 → 1178
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    7. NM_001366525.1 → NP_001353454.1  plasma membrane calcium-transporting ATPase 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variant 7, encodes isoform 2.
      Source sequence(s)
      AC009522, AC025034, AC068641
      Conserved Domains (2) summary
      TIGR01517
      Location:15 → 1064
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1103 → 1178
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    8. NM_001366526.1 → NP_001353455.1  plasma membrane calcium-transporting ATPase 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variant 10, encodes isoform 3.
      Source sequence(s)
      AC009522, AC025034, AC068641
      Consensus CDS
      CCDS91736.1
      Related
      ENSP00000516172.1, ENST00000705822.1
      Conserved Domains (2) summary
      TIGR01517
      Location:15 → 1064
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1103 → 1142
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    9. NM_001366527.1 → NP_001353456.1  plasma membrane calcium-transporting ATPase 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variant 9, encodes isoform 3.
      Source sequence(s)
      AC009522, AC025034, AC068641
      Consensus CDS
      CCDS91736.1
      Conserved Domains (2) summary
      TIGR01517
      Location:15 → 1064
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1103 → 1142
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    10. NM_001366528.1 → NP_001353457.1  plasma membrane calcium-transporting ATPase 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC009522, AC025034, AC068641
      Conserved Domains (2) summary
      pfam12424
      Location:1067 → 1106
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      cl27747
      Location:15 → 1023
      E1-E2_ATPase; E1-E2 ATPase

    11. NM_001366529.1 → NP_001353458.1  plasma membrane calcium-transporting ATPase 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC009522, AC025034, AC068641
      Conserved Domains (2) summary
      TIGR01517
      Location:15 → 1023
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1067 → 1106
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    12. NM_001366530.1 → NP_001353459.1  plasma membrane calcium-transporting ATPase 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC009522, AC025034, AC068641
      Conserved Domains (2) summary
      TIGR01517
      Location:15 → 998
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1037 → 1076
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    13. NM_001366531.1 → NP_001353460.1  plasma membrane calcium-transporting ATPase 1 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variant 15, encodes isoform 7.
      Source sequence(s)
      AC009522, AC025034, AC068641
      UniProtKB/TrEMBL
      Q59H63
      Conserved Domains (2) summary
      pfam12424
      Location:916 → 955
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      cl27747
      Location:15 → 877
      E1-E2_ATPase; E1-E2 ATPase

    14. NM_001366532.1 → NP_001353461.1  plasma membrane calcium-transporting ATPase 1 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variant 14, encodes isoform 7.
      Source sequence(s)
      AC009522, AC025034, AC068641
      UniProtKB/TrEMBL
      Q59H63
      Conserved Domains (2) summary
      pfam12424
      Location:916 → 955
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      cl27747
      Location:15 → 877
      E1-E2_ATPase; E1-E2 ATPase

    15. NM_001413046.1 → NP_001399975.1  plasma membrane calcium-transporting ATPase 1 isoform 1b

      Status: REVIEWED

      Source sequence(s)
      AC009522, AC025034, AC068641
      UniProtKB/Swiss-Prot
      P20020, Q12992, Q12993, Q13819, Q13820, Q13821, Q16504, Q93082

    16. NM_001413047.1 → NP_001399976.1  plasma membrane calcium-transporting ATPase 1 isoform 1b

      Status: REVIEWED

      Source sequence(s)
      AC009522, AC025034, AC068641
      UniProtKB/Swiss-Prot
      P20020, Q12992, Q12993, Q13819, Q13820, Q13821, Q16504, Q93082

    17. NM_001413048.1 → NP_001399977.1  plasma membrane calcium-transporting ATPase 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC009522, AC025034, AC068641

    18. NM_001413049.1 → NP_001399978.1  plasma membrane calcium-transporting ATPase 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC009522, AC025034, AC068641

    19. NM_001413050.1 → NP_001399979.1  plasma membrane calcium-transporting ATPase 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC009522, AC025034, AC068641

    20. NM_001413051.1 → NP_001399980.1  plasma membrane calcium-transporting ATPase 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC009522, AC025034, AC068641

    21. NM_001413052.1 → NP_001399981.1  plasma membrane calcium-transporting ATPase 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC009522, AC025034, AC068641

    22. NM_001413053.1 → NP_001399982.1  plasma membrane calcium-transporting ATPase 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC009522, AC025034, AC068641

    23. NM_001413054.1 → NP_001399983.1  plasma membrane calcium-transporting ATPase 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC009522, AC025034, AC068641

    24. NM_001413055.1 → NP_001399984.1  plasma membrane calcium-transporting ATPase 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC009522, AC025034, AC068641

    25. NM_001413056.1 → NP_001399985.1  plasma membrane calcium-transporting ATPase 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC009522, AC025034, AC068641

    26. NM_001413057.1 → NP_001399986.1  plasma membrane calcium-transporting ATPase 1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC009522, AC025034, AC068641

    27. NM_001413058.1 → NP_001399987.1  plasma membrane calcium-transporting ATPase 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC009522, AC025034, AC068641

    28. NM_001413059.1 → NP_001399988.1  plasma membrane calcium-transporting ATPase 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC009522, AC025034, AC068641

    29. NM_001413060.1 → NP_001399989.1  plasma membrane calcium-transporting ATPase 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC009522, AC025034, AC068641

    30. NM_001682.3 → NP_001673.2  plasma membrane calcium-transporting ATPase 1 isoform 1b

      See identical proteins and their annotated locations for NP_001673.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a segment in the coding region, which leads to a frameshift, compared to variant 1. The resulting isoform (1b) contains a longer and distinct C-terminus compared to isoform 1a. Variants 2-5, 16, and 17 all encode the same isoform (1b).
      Source sequence(s)
      AC009522, AC025034, AC068641
      Consensus CDS
      CCDS9035.1
      UniProtKB/Swiss-Prot
      P20020, Q12992, Q12993, Q13819, Q13820, Q13821, Q16504, Q93082
      Conserved Domains (2) summary
      TIGR01517
      Location:15 → 1064
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1103 → 1149
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    RNA

    1. NR_182093.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC009522, AC025034, AC068641

    2. NR_182094.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC009522, AC025034, AC068641

    3. NR_182095.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC009522, AC025034, AC068641

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      89588049..89709366 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428898.1 → XP_047284854.1  plasma membrane calcium-transporting ATPase 1 isoform X3

    2. XM_017019357.3 → XP_016874846.1  plasma membrane calcium-transporting ATPase 1 isoform X3

      Conserved Domains (2) summary
      TIGR01517
      Location:15 → 1023
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1067 → 1142
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    3. XM_024448993.2 → XP_024304761.1  plasma membrane calcium-transporting ATPase 1 isoform X4

      Conserved Domains (2) summary
      pfam12424
      Location:1067 → 1106
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      cl27747
      Location:15 → 1023
      E1-E2_ATPase; E1-E2 ATPase

    4. XM_047428890.1 → XP_047284846.1  plasma membrane calcium-transporting ATPase 1 isoform X1

    5. XM_047428892.1 → XP_047284848.1  plasma membrane calcium-transporting ATPase 1 isoform X1

    6. XM_047428893.1 → XP_047284849.1  plasma membrane calcium-transporting ATPase 1 isoform X1

    7. XM_047428894.1 → XP_047284850.1  plasma membrane calcium-transporting ATPase 1 isoform X1

    8. XM_047428897.1 → XP_047284853.1  plasma membrane calcium-transporting ATPase 1 isoform X2

      UniProtKB/Swiss-Prot
      P20020, Q12992, Q12993, Q13819, Q13820, Q13821, Q16504, Q93082

    9. XM_047428889.1 → XP_047284845.1  plasma membrane calcium-transporting ATPase 1 isoform X1

    10. XM_047428891.1 → XP_047284847.1  plasma membrane calcium-transporting ATPase 1 isoform X1

    11. XM_047428896.1 → XP_047284852.1  plasma membrane calcium-transporting ATPase 1 isoform X2

      UniProtKB/Swiss-Prot
      P20020, Q12992, Q12993, Q13819, Q13820, Q13821, Q16504, Q93082

    12. XM_047428900.1 → XP_047284856.1  plasma membrane calcium-transporting ATPase 1 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      89569850..89691243 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372130.1 → XP_054228105.1  plasma membrane calcium-transporting ATPase 1 isoform X6

    2. XM_054372129.1 → XP_054228104.1  plasma membrane calcium-transporting ATPase 1 isoform X3

    3. XM_054372128.1 → XP_054228103.1  plasma membrane calcium-transporting ATPase 1 isoform X2

      UniProtKB/Swiss-Prot
      P20020, Q12992, Q12993, Q13819, Q13820, Q13821, Q16504, Q93082

    4. XM_054372127.1 → XP_054228102.1  plasma membrane calcium-transporting ATPase 1 isoform X1

    5. XM_054372131.1 → XP_054228106.1  plasma membrane calcium-transporting ATPase 1 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20020.4 GenPept UniProtKB/Swiss-Prot:P20020

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