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    DBI diazepam binding inhibitor, acyl-CoA binding protein [ Homo sapiens (human) ]

    Gene ID: 1622, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DBIprovided by HGNC
    Official Full Name
    diazepam binding inhibitor, acyl-CoA binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:2690
    See related
    Ensembl:ENSG00000155368 MIM:125950; AllianceGenome:HGNC:2690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EP; ACBP; ACBD1; CCK-RP
    Summary
    This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in prostate (RPKM 97.8), liver (RPKM 93.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DBI in Genome Data Viewer
    Location:
    2q14.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (119366977..119372543)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (119800515..119806082)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (120124553..120130119)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene STEAP3 metalloreductase Neighboring gene STEAP3 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:120011987-120012930 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:120013256-120014122 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:120016992-120017765 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11902 Neighboring gene uncharacterized LOC105373581 Neighboring gene NANOG hESC enhancer GRCh37_chr2:120049626-120050127 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120051788-120052288 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120052289-120052789 Neighboring gene chromosome 2 open reading frame 76 Neighboring gene NANOG hESC enhancer GRCh37_chr2:120064909-120065410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11903 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16447 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16448 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16449 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11904 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16451 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11905 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120189865-120190371 Neighboring gene transmembrane protein 37 Neighboring gene secretin receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120231245-120231796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120232347-120232897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120238515-120239026 Neighboring gene VISTA enhancer hs1941 Neighboring gene SCTR antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Diazepam binding inhibitor and dehydroepiandrosterone sulphate plasma levels in borderline personality disorder adolescents. Conti E, et al. Neuropsychobiology, 2014. PMID 24401326
    2. ACTH-induced mitochondrial DBI receptor (MDR) and diazepam binding inhibitor (DBI) expression in adrenals of hypophysectomized rats is not cause-effect related to its immediate steroidogenic action. Cavallaro S, et al. Life Sci, 1993. PMID 8396705
    3. A human gene encoding diazepam-binding inhibitor/acy1-CoA-binding protein: transcription and hormonal regulation in the androgen-sensitive human prostatic adenocarcinoma cell line LNCaP. Swinnen JV, et al. DNA Cell Biol, 1996 Mar. PMID 8634149
    4. Diazepam binding inhibitor (DBI) in the plasma of pediatric and adult epileptic patients. Ferrarese C, et al. Epilepsy Res, 1998 Jan. PMID 9477145
    5. Diazepam binding inhibitor and total cholesterol plasma levels in cirrhosis and hepatocellular carcinoma. Venturini I, et al. Regul Pept, 1998 Apr 24. PMID 9657356

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer diagnosis and an inhibitor of immunosurveillance.
      Title: Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer diagnosis and an inhibitor of immunosurveillance.
    2. Acyl coenzyme A binding protein (ACBP): An aging- and disease-relevant "autophagy checkpoint".
      Title: Acyl coenzyme A binding protein (ACBP): An aging- and disease-relevant "autophagy checkpoint".
    3. Targeting fatty acid oxidation via Acyl-CoA binding protein hinders glioblastoma invasion.
      Title: Targeting fatty acid oxidation via Acyl-CoA binding protein hinders glioblastoma invasion.
    4. Acyl-CoA binding protein (ACBP) is highly expressed in the developing human kidney.
      Title: Acyl-CoA binding protein (ACBP) is highly expressed in the developing human kidney.
    5. Serum DBI and biomarkers of neuroinflammation in Alzheimer's disease and delirium.
      Title: Serum DBI and biomarkers of neuroinflammation in Alzheimer's disease and delirium.
    6. Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity.
      Title: Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity.
    7. By subgrouping individuals with ASD based on clinical phenotypes, and then performing an integrated transcriptome-proteome analysis, we identified DBI as a novel candidate protein for ASD with severe language impairment.
      Title: Phenotypic subgrouping and multi-omics analyses reveal reduced diazepam-binding inhibitor (DBI) protein levels in autism spectrum disorder with severe language impairment.
    8. was no significant difference in the rs2276596 genotype and allele frequencies of the DBI gene between these psychoses and healthy controls
      Title: No Relationships between Psychosis and the Diazepam Binding Inhibitor rs2276596 (C/A) Polymorphism in Japanese: An Exploratory Study.
    9. ACBP increases the activity of ceramide synthase 2 (CerS2) by more than 2-fold and CerS3 activity by 7-fold. ACBP binds very-long-chain acyl-CoA esters, which is required for its ability to stimulate CerS activity.
      Title: Regulation of very-long acyl chain ceramide synthesis by acyl-CoA-binding protein.
    10. Serum endozepine-4 levels are increased in hepatic coma.
      Title: Endozepine-4 levels are increased in hepatic coma.
    Submit: New GeneRIF Correction See all GeneRIFs (31)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC70414

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables benzodiazepine receptor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables fatty-acyl-CoA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables long-chain fatty acyl-CoA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of protein lipidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylcholine acyl-chain remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of CoA-transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of phospholipid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in perinuclear endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-lipid complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    acyl-CoA-binding protein
    Names
    GABA receptor modulator
    acyl coenzyme A binding protein
    acyl-Coenzyme A binding domain containing 1
    cholecystokinin-releasing peptide, trypsin-sensitive
    diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
    diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)
    diazepam-binding inhibitor
    endozepine
    epididymis secretory sperm binding protein
    NP_001073331.1
    NP_001073332.1
    NP_001171488.1
    NP_001171512.1
    NP_001171513.1
    NP_001171514.1
    NP_001269562.1
    NP_001269563.1
    NP_001269564.1
    NP_001269565.1
    NP_001339361.1
    NP_065438.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079862.4 → NP_001073331.1  acyl-CoA-binding protein isoform 3

      See identical proteins and their annotated locations for NP_001073331.1

      Status: REVIEWED

      Source sequence(s)
      AC016736
      Consensus CDS
      CCDS42740.1
      UniProtKB/Swiss-Prot
      B8ZWD2, B8ZWD6, B8ZWD7, P07108, P08869, Q4VWZ6, Q53SQ7, Q6IB48, Q9UCI8
      Related
      ENSP00000348116.3, ENST00000355857.8
      Conserved Domains (1) summary
      cd00435
      Location:2 → 86
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    2. NM_001079863.3 → NP_001073332.1  acyl-CoA-binding protein isoform 2

      See identical proteins and their annotated locations for NP_001073332.1

      Status: REVIEWED

      Source sequence(s)
      AC016736
      Consensus CDS
      CCDS42741.1
      UniProtKB/Swiss-Prot
      P07108
      Related
      ENSP00000376815.2, ENST00000393103.2
      Conserved Domains (1) summary
      cd00435
      Location:5 → 87
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    3. NM_001178017.3 → NP_001171488.1  acyl-CoA-binding protein isoform 4

      See identical proteins and their annotated locations for NP_001171488.1

      Status: REVIEWED

      Source sequence(s)
      AC016736
      Consensus CDS
      CCDS54391.1
      UniProtKB/Swiss-Prot
      P07108
      Related
      ENSP00000486361.1, ENST00000627305.2
      Conserved Domains (1) summary
      cd00435
      Location:74 → 147
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    4. NM_001178041.4 → NP_001171512.1  acyl-CoA-binding protein isoform 5

      See identical proteins and their annotated locations for NP_001171512.1

      Status: REVIEWED

      Source sequence(s)
      AC016736
      Consensus CDS
      CCDS54390.1
      UniProtKB/Swiss-Prot
      P07108
      Related
      ENSP00000486281.1, ENST00000627093.2
      Conserved Domains (1) summary
      cd00435
      Location:55 → 128
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    5. NM_001178042.4 → NP_001171513.1  acyl-CoA-binding protein isoform 1

      See identical proteins and their annotated locations for NP_001171513.1

      Status: REVIEWED

      Source sequence(s)
      AC016736
      Consensus CDS
      CCDS2126.1
      UniProtKB/TrEMBL
      A0A024RAF2
      Conserved Domains (1) summary
      cd00435
      Location:30 → 103
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    6. NM_001178043.4 → NP_001171514.1  acyl-CoA-binding protein isoform 6

      See identical proteins and their annotated locations for NP_001171514.1

      Status: REVIEWED

      Source sequence(s)
      AC016736
      Consensus CDS
      CCDS74568.1
      UniProtKB/TrEMBL
      B8ZWD1
      Related
      ENSP00000442917.2, ENST00000535617.5
      Conserved Domains (1) summary
      cd00435
      Location:23 → 96
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    7. NM_001282633.3 → NP_001269562.1  acyl-CoA-binding protein isoform 1

      See identical proteins and their annotated locations for NP_001269562.1

      Status: REVIEWED

      Source sequence(s)
      AC016736
      Consensus CDS
      CCDS2126.1
      UniProtKB/TrEMBL
      A0A024RAF2
      Related
      ENSP00000439012.1, ENST00000535757.5
      Conserved Domains (1) summary
      cd00435
      Location:30 → 103
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    8. NM_001282634.3 → NP_001269563.1  acyl-CoA-binding protein isoform 1

      See identical proteins and their annotated locations for NP_001269563.1

      Status: REVIEWED

      Source sequence(s)
      AC016736
      Consensus CDS
      CCDS2126.1
      UniProtKB/TrEMBL
      A0A024RAF2
      Related
      ENSP00000386486.1, ENST00000409094.5
      Conserved Domains (1) summary
      cd00435
      Location:30 → 103
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    9. NM_001282635.3 → NP_001269564.1  acyl-CoA-binding protein isoform 1

      See identical proteins and their annotated locations for NP_001269564.1

      Status: REVIEWED

      Source sequence(s)
      AC016736
      Consensus CDS
      CCDS2126.1
      UniProtKB/TrEMBL
      A0A024RAF2
      Related
      ENSP00000311117.4, ENST00000311521.8
      Conserved Domains (1) summary
      cd00435
      Location:30 → 103
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    10. NM_001282636.3 → NP_001269565.1  acyl-CoA-binding protein isoform 7

      See identical proteins and their annotated locations for NP_001269565.1

      Status: REVIEWED

      Source sequence(s)
      AC016736
      UniProtKB/TrEMBL
      B8ZWD8
      Conserved Domains (1) summary
      cl00221
      Location:1 → 62
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    11. NM_001352432.3 → NP_001339361.1  acyl-CoA-binding protein isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC016736
      UniProtKB/TrEMBL
      B8ZWD8
      Related
      ENST00000460901.1
      Conserved Domains (1) summary
      cl00221
      Location:1 → 62
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    12. NM_020548.9 → NP_065438.1  acyl-CoA-binding protein isoform 1

      See identical proteins and their annotated locations for NP_065438.1

      Status: REVIEWED

      Source sequence(s)
      AC016736
      Consensus CDS
      CCDS2126.1
      UniProtKB/TrEMBL
      A0A024RAF2
      Conserved Domains (1) summary
      cd00435
      Location:30 → 103
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      119366977..119372543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      119800515..119806082
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07108.2 GenPept UniProtKB/Swiss-Prot:P07108

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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