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    CAPG capping actin protein, gelsolin like [ Homo sapiens (human) ]

    Gene ID: 822, updated on 3-Dec-2024

    Summary

    Official Symbol
    CAPGprovided by HGNC
    Official Full Name
    capping actin protein, gelsolin likeprovided by HGNC
    Primary source
    HGNC:HGNC:1474
    See related
    Ensembl:ENSG00000042493 MIM:153615; AllianceGenome:HGNC:1474
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCP; AFCP; HEL-S-66
    Summary
    This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2012]
    Expression
    Broad expression in lung (RPKM 44.7), esophagus (RPKM 37.5) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CAPG in Genome Data Viewer
    Location:
    2p11.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (85391602..85419540, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (85393613..85421559, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85621876..85641139, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ELMO domain containing 3 Neighboring gene RNA, 7SL, cytoplasmic 113, pseudogene Neighboring gene U7 small nuclear RNA Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85628953-85629452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16122 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11697 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:85640593-85641094 Neighboring gene uncharacterized LOC105374841 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16124 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85645284-85645819 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16126 Neighboring gene SH2 domain containing 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85658733-85659404 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85659405-85660075 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85660076-85660746 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11699 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11700 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85665369-85665885 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85665886-85666401 Neighboring gene RNA, 7SL, cytoplasmic 251, pseudogene Neighboring gene RNA, U7 small nuclear 64 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Interaction of HIV-1 Tat with CAPG in T-cells is identified by a proteomic strategy based on affinity chromatography coupled with mass spectrometry PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of capping protein gelsolin-like (CAPG) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cadherin binding HDA PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin filament severing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell projection assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT involved_in extracellular matrix disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in positive regulation of podosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein-containing complex assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of F-actin capping protein complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in Flemming body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    macrophage-capping protein
    Names
    actin-regulatory protein CAP-G
    capping protein (actin filament), gelsolin-like
    epididymis secretory protein Li 66
    gelsolin-like capping protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256139.2NP_001243068.1  macrophage-capping protein isoform 1

      See identical proteins and their annotated locations for NP_001243068.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 all encode the same isoform (1).
      Source sequence(s)
      AK130130, AK313898, AU099216, BU626913
      Consensus CDS
      CCDS1974.1
      UniProtKB/Swiss-Prot
      B8ZZS7, D6W5K8, P40121, Q53SA7
      UniProtKB/TrEMBL
      B2R9S4, V9HW69
      Related
      ENSP00000386965.1, ENST00000409724.5
      Conserved Domains (3) summary
      cd11289
      Location:137225
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:17120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:251346
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    2. NM_001256140.2NP_001243069.1  macrophage-capping protein isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK130130, AK225374, BU626913
      Consensus CDS
      CCDS58715.1
      UniProtKB/TrEMBL
      B2R9S4
      Related
      ENSP00000387063.1, ENST00000409921.5
      Conserved Domains (3) summary
      cd11289
      Location:137208
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:17120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:236331
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    3. NM_001320732.2NP_001307661.1  macrophage-capping protein isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 all encode the same isoform (1).
      Source sequence(s)
      BG762391, FJ224312
      Consensus CDS
      CCDS1974.1
      UniProtKB/Swiss-Prot
      B8ZZS7, D6W5K8, P40121, Q53SA7
      UniProtKB/TrEMBL
      B2R9S4, V9HW69
      Conserved Domains (3) summary
      cd11289
      Location:137225
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:17120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:251346
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    4. NM_001320733.2NP_001307662.1  macrophage-capping protein isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 all encode the same isoform (1).
      Source sequence(s)
      BG762114, FJ224312
      Consensus CDS
      CCDS1974.1
      UniProtKB/Swiss-Prot
      B8ZZS7, D6W5K8, P40121, Q53SA7
      UniProtKB/TrEMBL
      B2R9S4, V9HW69
      Conserved Domains (3) summary
      cd11289
      Location:137225
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:17120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:251346
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    5. NM_001320734.2NP_001307663.1  macrophage-capping protein isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK130130, BU172582, FJ224312
      UniProtKB/TrEMBL
      B2R9S4
      Conserved Domains (3) summary
      cd11289
      Location:137223
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:17120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:221315
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    6. NM_001747.4NP_001738.2  macrophage-capping protein isoform 1

      See identical proteins and their annotated locations for NP_001738.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1, 2, 4, and 5 all encode the same isoform (1).
      Source sequence(s)
      AK130130, BU626913
      Consensus CDS
      CCDS1974.1
      UniProtKB/Swiss-Prot
      B8ZZS7, D6W5K8, P40121, Q53SA7
      UniProtKB/TrEMBL
      B2R9S4, V9HW69
      Related
      ENSP00000263867.4, ENST00000263867.9
      Conserved Domains (3) summary
      cd11289
      Location:137225
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:17120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:251346
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      85391602..85419540 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047445951.1XP_047301907.1  macrophage-capping protein isoform X1

      UniProtKB/TrEMBL
      B2R9S4
    2. XM_047445948.1XP_047301904.1  macrophage-capping protein isoform X1

      UniProtKB/TrEMBL
      B2R9S4
    3. XM_047445950.1XP_047301906.1  macrophage-capping protein isoform X1

      UniProtKB/TrEMBL
      B2R9S4
    4. XM_047445947.1XP_047301903.1  macrophage-capping protein isoform X1

      UniProtKB/TrEMBL
      B2R9S4
    5. XM_047445949.1XP_047301905.1  macrophage-capping protein isoform X1

      UniProtKB/TrEMBL
      B2R9S4
    6. XM_047445952.1XP_047301908.1  macrophage-capping protein isoform X1

      UniProtKB/TrEMBL
      B2R9S4
    7. XM_047445953.1XP_047301909.1  macrophage-capping protein isoform X2

      UniProtKB/Swiss-Prot
      B8ZZS7, D6W5K8, P40121, Q53SA7
      UniProtKB/TrEMBL
      B2R9S4, V9HW69
    8. XM_011533122.2XP_011531424.1  macrophage-capping protein isoform X2

      See identical proteins and their annotated locations for XP_011531424.1

      UniProtKB/Swiss-Prot
      B8ZZS7, D6W5K8, P40121, Q53SA7
      UniProtKB/TrEMBL
      B2R9S4, V9HW69
      Conserved Domains (3) summary
      cd11289
      Location:137225
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:17120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:251346
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    9. XM_011533123.2XP_011531425.1  macrophage-capping protein isoform X2

      See identical proteins and their annotated locations for XP_011531425.1

      UniProtKB/Swiss-Prot
      B8ZZS7, D6W5K8, P40121, Q53SA7
      UniProtKB/TrEMBL
      B2R9S4, V9HW69
      Conserved Domains (3) summary
      cd11289
      Location:137225
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:17120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:251346
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    10. XM_047445954.1XP_047301910.1  macrophage-capping protein isoform X2

      UniProtKB/Swiss-Prot
      B8ZZS7, D6W5K8, P40121, Q53SA7
      UniProtKB/TrEMBL
      B2R9S4, V9HW69

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      85393613..85421559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344102.1XP_054200077.1  macrophage-capping protein isoform X1

      UniProtKB/TrEMBL
      B2R9S4
    2. XM_054344101.1XP_054200076.1  macrophage-capping protein isoform X1

      UniProtKB/TrEMBL
      B2R9S4
    3. XM_054344099.1XP_054200074.1  macrophage-capping protein isoform X1

      UniProtKB/TrEMBL
      B2R9S4
    4. XM_054344100.1XP_054200075.1  macrophage-capping protein isoform X1

      UniProtKB/TrEMBL
      B2R9S4
    5. XM_054344104.1XP_054200079.1  macrophage-capping protein isoform X2

      UniProtKB/TrEMBL
      B2R9S4
    6. XM_054344106.1XP_054200081.1  macrophage-capping protein isoform X2

      UniProtKB/TrEMBL
      B2R9S4
    7. XM_054344103.1XP_054200078.1  macrophage-capping protein isoform X2

      UniProtKB/TrEMBL
      B2R9S4
    8. XM_054344105.1XP_054200080.1  macrophage-capping protein isoform X2

      UniProtKB/TrEMBL
      B2R9S4