SCTR secretin receptor [Homo sapiens (human)] - Gene

Summary

Official Symbol: SCTRprovided by HGNC
Official Full Name: secretin receptorprovided by HGNC
Primary source: HGNC:HGNC:10608
See related: Ensembl:ENSG00000080293 MIM:182098; AllianceGenome:HGNC:10608
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SR
Summary: The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism. [provided by RefSeq, Jul 2008]
Expression: Biased expression in duodenum (RPKM 6.3), pancreas (RPKM 4.3) and 5 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q14.2

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (119439843..119524483, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (119873301..119957984, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (120197419..120282059, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of Secretin and its Receptor Along the Intestinal Tract in Type 2 Diabetes Patients and Healthy Controls.
Title: Expression of Secretin and its Receptor Along the Intestinal Tract in Type 2 Diabetes Patients and Healthy Controls.
Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes.
Title: Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes.
Structure of the human secretin receptor coupled to an engineered heterotrimeric G protein.
Title: Structure of the human secretin receptor coupled to an engineered heterotrimeric G protein.
SCTR hypermethylation is a diagnostic biomarker in colorectal cancer.
Title: SCTR hypermethylation is a diagnostic biomarker in colorectal cancer.
Structure and dynamics of the active Gs-coupled human secretin receptor.
Title: Structure and dynamics of the active Gs-coupled human secretin receptor.
High secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early-stage primary biliary cholangitis.
Title: Secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early-stage primary biliary cholangitis.
elevated in primary sclerosing cholangitis liver samples compared to healthy controls
Title: The secretin/secretin receptor axis modulates liver fibrosis through changes in transforming growth factor-β1 biliary secretion in mice.
Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors.
Title: Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors.
Cysteine trapping identified charge-charge interactions between secretin and secretin receptor residues in TM5, TM6, ECL2, and ECL3 domains.
Title: Use of Cysteine Trapping to Map Spatial Approximations between Residues Contributing to the Helix N-capping Motif of Secretin and Distinct Residues within Each of the Extracellular Loops of Its Receptor.
Our findings indicate that SCTR suppresses the proliferation of normal breast cells, while the gene stimulates the proliferation and migration of cancer cells being downregulated by promoter methylation.
Title: SCTR regulates cell cycle-related genes toward anti-proliferation in normal breast cells while having pro-proliferation activity in breast cancer cells.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH68868 (e-PCR)
- UniSTS:71982

SHGC-104924 (e-PCR)
- UniSTS:169027

STS-U28281 (e-PCR)
- UniSTS:11943

RH79136 (e-PCR)
- UniSTS:84988

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	IPI Inferred from Physical Interaction more info	PubMed
enables secretin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables secretin receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in diet induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular water homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of appetite	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to nutrient levels	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasmic microtubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: secretin receptor

Names: pancreatic secretin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029904.1 RefSeqGene

Range

4970..89610

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002980.3 → NP_002971.2 secretin receptor precursor

See identical proteins and their annotated locations for NP_002971.2

Status: REVIEWED

Source sequence(s)

AC013275

Consensus CDS

CCDS2127.1

UniProtKB/Swiss-Prot

P47872, Q12961, Q13213, Q53T00

UniProtKB/TrEMBL

B2RBF3, Q8IV17

Related

ENSP00000019103.6, ENST00000019103.8

Conserved Domains (2) summary

pfam00002
Location:139 → 384

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02793
Location:64 → 126

HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

119439843..119524483 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011511621.3 → XP_011509923.1 secretin receptor isoform X3

UniProtKB/TrEMBL

B2RBF3, Q8IV17

Conserved Domains (2) summary

pfam00002
Location:139 → 389

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02793
Location:64 → 126

HRM; Hormone receptor domain
XM_047445401.1 → XP_047301357.1 secretin receptor isoform X5
XM_047445400.1 → XP_047301356.1 secretin receptor isoform X2
XM_047445399.1 → XP_047301355.1 secretin receptor isoform X1
XM_017004670.2 → XP_016860159.2 secretin receptor isoform X4
XM_047445403.1 → XP_047301359.1 secretin receptor isoform X7
XM_047445402.1 → XP_047301358.1 secretin receptor isoform X6
XM_047445404.1 → XP_047301360.1 secretin receptor isoform X8