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    LEPR leptin receptor [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574126, updated on 17-Aug-2024

    Summary

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    Official Symbol
    LEPRprovided by VGNC
    Official Full Name
    leptin receptorprovided by VGNC
    Primary source
    VGNC:VGNC:81429
    See related
    Ensembl:ENSMMUG00000003265
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    OBR
    Orthologs
    human mouse all
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    Genomic context

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    See LEPR in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (158798340..158896008, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (65271597..65369629)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106999122 Neighboring gene phosphodiesterase 4B Neighboring gene U4 spliceosomal RNA Neighboring gene polypeptide N-acetylgalactosaminyltransferase 11-like Neighboring gene small nucleolar RNA U13 Neighboring gene U2 spliceosomal RNA Neighboring gene leptin receptor overlapping transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Monkey leptin receptor mRNA: sequence, tissue distribution, and mRNA expression in the adipose tissue of normal, hyperinsulinemic, and type 2 diabetic rhesus monkeys. Hotta K, et al. Obes Res, 1998 Sep. PMID 9738551
    2. Effect of fasting on cocaine-amphetamine-regulated transcript, neuropeptide Y, and leptin receptor expression in the non-human primate hypothalamus. Van Vugt DA, et al. Neuroendocrinology, 2006. PMID 17124379
    3. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A 2-day fast increased leptin receptor (Ob-R) expression in the ventromedial nucleus (VMN).
      Title: Effect of fasting on cocaine-amphetamine-regulated transcript, neuropeptide Y, and leptin receptor expression in the non-human primate hypothalamus.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leptin receptor
    Names
    LEP-R
    OB receptor
    OB-R

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032819.1 → NP_001027991.1  leptin receptor precursor

      See identical proteins and their annotated locations for NP_001027991.1

      Status: PROVISIONAL

      Source sequence(s)
      AF225874
      UniProtKB/Swiss-Prot
      Q9MYK9, Q9MYL0, Q9MYL1, Q9MYL2
      Conserved Domains (3) summary
      cd00063
      Location:235 → 328
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:739 → 810
      fn3; Fibronectin type III domain
      pfam06328
      Location:331 → 418
      Lep_receptor_Ig; Ig-like C2-type domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      158798340..158896008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015141353.2 → XP_014996839.2  leptin receptor isoform X2

      UniProtKB/Swiss-Prot
      Q9MYK9, Q9MYL0, Q9MYL1, Q9MYL2
      UniProtKB/TrEMBL
      F7DIQ3
      Related
      ENSMMUP00000004351.4, ENSMMUT00000004617.4
      Conserved Domains (3) summary
      smart00060
      Location:739 → 818
      FN3; Fibronectin type 3 domain
      cd00063
      Location:235 → 328
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:331 → 418
      Lep_receptor_Ig; Ig-like C2-type domain

    2. XM_015141349.2 → XP_014996835.2  leptin receptor isoform X1

      UniProtKB/Swiss-Prot
      Q9MYK9, Q9MYL0, Q9MYL1, Q9MYL2
      Conserved Domains (3) summary
      smart00060
      Location:739 → 818
      FN3; Fibronectin type 3 domain
      cd00063
      Location:235 → 328
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:331 → 418
      Lep_receptor_Ig; Ig-like C2-type domain

    3. XM_015141359.2 → XP_014996845.1  leptin receptor isoform X4

      UniProtKB/TrEMBL
      F7DIP7
      Related
      ENSMMUP00000004352.4, ENSMMUT00000004618.4
      Conserved Domains (3) summary
      cd00063
      Location:235 → 328
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:739 → 810
      fn3; Fibronectin type III domain
      pfam06328
      Location:331 → 418
      Lep_receptor_Ig; Ig-like C2-type domain

    4. XM_015141356.2 → XP_014996842.1  leptin receptor isoform X3

      Conserved Domains (3) summary
      cd00063
      Location:235 → 328
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:739 → 810
      fn3; Fibronectin type III domain
      pfam06328
      Location:331 → 418
      Lep_receptor_Ig; Ig-like C2-type domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9MYL0.2 GenPept UniProtKB/Swiss-Prot:Q9MYL0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.