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    DNMT3B DNA methyltransferase 3 beta [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 711553, updated on 17-Aug-2024

    Summary

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    Official Symbol
    DNMT3Bprovided by VGNC
    Official Full Name
    DNA methyltransferase 3 betaprovided by VGNC
    Primary source
    VGNC:VGNC:71960
    See related
    Ensembl:ENSMMUG00000019474
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See DNMT3B in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 10 NC_041763.1 (67997485..68046324)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 10 NC_027902.1 (31315815..31364942, complement)

    Chromosome 10 - NC_041763.1Genomic Context describing neighboring genes Neighboring gene chromosome 10 C20orf203 homolog Neighboring gene COMM domain containing 7 Neighboring gene microtubule associated protein RP/EB family member 1 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene EF-hand calcium binding domain 8 Neighboring gene 40S ribosomal protein S12-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA (cytosine-5)-methyltransferase 3B
    XP_015004695.2
    XP_015004696.1
    XP_015004697.1
    XP_028684149.1
    XP_028684150.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041763.1 Reference Mmul_10 Primary Assembly

      Range
      67997485..68046324
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015149209.2 → XP_015004695.2  DNA (cytosine-5)-methyltransferase 3B isoform X1

      UniProtKB/TrEMBL
      A0A1D5RIZ5
      Related
      ENSMMUP00000025594.4, ENSMMUT00000027362.4
      Conserved Domains (3) summary
      cd05835
      Location:223 → 309
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
      COG0270
      Location:554 → 736
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      cd11728
      Location:411 → 530
      ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)

    2. XM_015149210.2 → XP_015004696.1  DNA (cytosine-5)-methyltransferase 3B isoform X3

      UniProtKB/TrEMBL
      A0A1D5QWU6, I2CWK3
      Conserved Domains (3) summary
      cd05835
      Location:223 → 309
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
      COG0270
      Location:554 → 716
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      cd11728
      Location:411 → 530
      ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)

    3. XM_015149211.2 → XP_015004697.1  DNA (cytosine-5)-methyltransferase 3B isoform X4

      UniProtKB/TrEMBL
      A0A5F8AIR1
      Conserved Domains (3) summary
      cd05835
      Location:181 → 267
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
      COG0270
      Location:512 → 674
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      cd11728
      Location:369 → 488
      ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)

    4. XM_028828316.1 → XP_028684149.1  DNA (cytosine-5)-methyltransferase 3B isoform X2

      UniProtKB/TrEMBL
      A0A5F8AIR1
      Related
      ENSMMUP00000076853.1, ENSMMUT00000096086.1
      Conserved Domains (3) summary
      cd05835
      Location:181 → 267
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
      COG0270
      Location:512 → 694
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      cd11728
      Location:369 → 488
      ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)

    5. XM_028828317.1 → XP_028684150.1  DNA (cytosine-5)-methyltransferase 3B isoform X5

      UniProtKB/TrEMBL
      A0A1D5QWU6
      Related
      ENSMMUP00000052526.2, ENSMMUT00000054891.2
      Conserved Domains (3) summary
      cd05835
      Location:223 → 309
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
      COG0270
      Location:554 → 716
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      cd11728
      Location:411 → 530
      ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
    Nucleotide Protein
    Heading Accession and Version

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