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    SCN8A sodium voltage-gated channel alpha subunit 8 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 695972, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SCN8Aprovided by VGNC
    Official Full Name
    sodium voltage-gated channel alpha subunit 8provided by VGNC
    Primary source
    VGNC:VGNC:76989
    See related
    Ensembl:ENSMMUG00000000415
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See SCN8A in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 11 NC_041764.1 (51204385..51418408)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 11 NC_027903.1 (49898075..50114166)

    Chromosome 11 - NC_041764.1Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene polypeptide N-acetylgalactosaminyltransferase 6 Neighboring gene uncharacterized LOC114670847 Neighboring gene solute carrier family 4 member 8 Neighboring gene heterogeneous nuclear ribonucleoprotein A3-like Neighboring gene fidgetin like 2 Neighboring gene ankyrin repeat domain 33

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables voltage-gated sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in membrane depolarization during action potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuronal action potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of voltage-gated sodium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sodium channel protein type 8 subunit alpha
    Names
    sodium channel, voltage gated, type VIII, alpha subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041764.1 Reference Mmul_10 Primary Assembly

      Range
      51204385..51418408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028829495.1 → XP_028685328.1  sodium channel protein type 8 subunit alpha isoform X1

      UniProtKB/TrEMBL
      G7N706
      Conserved Domains (6) summary
      smart00015
      Location:1905 → 1926
      IQ; Calmodulin-binding motif
      cd13433
      Location:1476 → 1528
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1208 → 1484
      Ion_trans; Ion transport protein
      pfam06512
      Location:1002 → 1203
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:502 → 703
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1791 → 1854
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    2. XM_028829497.1 → XP_028685330.1  sodium channel protein type 8 subunit alpha isoform X3

      UniProtKB/TrEMBL
      F7ADS8, G7N706
      Related
      ENSMMUP00000064417.1, ENSMMUT00000089898.1
      Conserved Domains (6) summary
      smart00015
      Location:1894 → 1915
      IQ; Calmodulin-binding motif
      cd13433
      Location:1465 → 1517
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1197 → 1473
      Ion_trans; Ion transport protein
      pfam06512
      Location:991 → 1192
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:502 → 692
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1780 → 1843
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    3. XM_028829498.1 → XP_028685331.1  sodium channel protein type 8 subunit alpha isoform X4

      UniProtKB/TrEMBL
      F7ADR2, G7N706
      Related
      ENSMMUP00000000558.4, ENSMMUT00000000607.4
      Conserved Domains (6) summary
      smart00015
      Location:1894 → 1915
      IQ; Calmodulin-binding motif
      cd13433
      Location:1465 → 1517
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1197 → 1473
      Ion_trans; Ion transport protein
      pfam06512
      Location:991 → 1192
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:502 → 692
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1780 → 1843
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    4. XM_028829499.1 → XP_028685332.1  sodium channel protein type 8 subunit alpha isoform X5

      UniProtKB/TrEMBL
      F7AD73
      Conserved Domains (6) summary
      smart00015
      Location:1853 → 1874
      IQ; Calmodulin-binding motif
      cd13433
      Location:1424 → 1476
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1481 → 1735
      Ion_trans; Ion transport protein
      pfam06512
      Location:991 → 1192
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:502 → 692
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1739 → 1802
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    5. XM_028829496.1 → XP_028685329.1  sodium channel protein type 8 subunit alpha isoform X2

      UniProtKB/TrEMBL
      G7N706
      Conserved Domains (6) summary
      smart00015
      Location:1905 → 1926
      IQ; Calmodulin-binding motif
      cd13433
      Location:1476 → 1528
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1208 → 1484
      Ion_trans; Ion transport protein
      pfam06512
      Location:1002 → 1203
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:502 → 703
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1791 → 1854
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    Nucleotide Protein
    Heading Accession and Version

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