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    PTPN4 protein tyrosine phosphatase non-receptor type 4 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 695516, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PTPN4provided by VGNC
    Official Full Name
    protein tyrosine phosphatase non-receptor type 4provided by VGNC
    Primary source
    VGNC:VGNC:76605
    See related
    Ensembl:ENSMMUG00000005610
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PTPN4 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 12 NC_041765.1 (11126470..11361422, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 12 NC_027904.1 (11177665..11413151, complement)

    Chromosome 12 - NC_041765.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 185B Neighboring gene erythrocyte membrane protein band 4.1 like 5 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC114671306 Neighboring gene uncharacterized LOC100428376 Neighboring gene uncharacterized LOC114671307 Neighboring gene transmembrane protein 177

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type 4
    NP_001253553.1
    XP_014965373.1
    XP_028686236.1
    XP_028686237.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001266624.1 → NP_001253553.1  tyrosine-protein phosphatase non-receptor type 4

      See identical proteins and their annotated locations for NP_001253553.1

      Status: PROVISIONAL

      Source sequence(s)
      JU476581
      UniProtKB/TrEMBL
      A0A5F8A8X3, F6WK37
      Related
      ENSMMUP00000007416.2, ENSMMUT00000007891.4
      Conserved Domains (5) summary
      smart00295
      Location:30 → 222
      B41; Band 4.1 homologues
      cd13189
      Location:216 → 310
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00595
      Location:517 → 602
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam08736
      Location:325 → 365
      FA; FERM adjacent (FA)
      cl28904
      Location:641 → 914
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041765.1 Reference Mmul_10 Primary Assembly

      Range
      11126470..11361422 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015109887.2 → XP_014965373.1  tyrosine-protein phosphatase non-receptor type 4 isoform X2

      UniProtKB/TrEMBL
      A0A5F8A8X3
      Conserved Domains (5) summary
      cd00992
      Location:399 → 486
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:100 → 194
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      cd14473
      Location:6 → 98
      FERM_B-lobe; FERM domain B-lobe
      pfam08736
      Location:207 → 249
      FA; FERM adjacent (FA)
      cl28904
      Location:525 → 798
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    2. XM_028830403.1 → XP_028686236.1  tyrosine-protein phosphatase non-receptor type 4 isoform X1

      UniProtKB/TrEMBL
      A0A5F8A8X3, F6WK37
      Conserved Domains (5) summary
      smart00295
      Location:30 → 222
      B41; Band 4.1 homologues
      cd13189
      Location:216 → 310
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00595
      Location:517 → 602
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam08736
      Location:325 → 365
      FA; FERM adjacent (FA)
      cl28904
      Location:641 → 914
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    3. XM_028830404.1 → XP_028686237.1  tyrosine-protein phosphatase non-receptor type 4 isoform X1

      UniProtKB/TrEMBL
      A0A5F8A8X3, F6WK37
      Conserved Domains (5) summary
      smart00295
      Location:30 → 222
      B41; Band 4.1 homologues
      cd13189
      Location:216 → 310
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00595
      Location:517 → 602
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam08736
      Location:325 → 365
      FA; FERM adjacent (FA)
      cl28904
      Location:641 → 914
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    Nucleotide Protein
    Heading Accession and Version

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