MSRB1 methionine sulfoxide reductase B1 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: MSRB1provided by VGNC
Official Full Name: methionine sulfoxide reductase B1provided by VGNC
Primary source: VGNC:VGNC:99524
See related: Ensembl:ENSMMUG00000007936
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as: SEPX1
Summary: The protein encoded by this gene belongs to the methionine-R-sulfoxide reductase B (MsrB) family. Members of this family function as repair enzymes that protect proteins from oxidative stress by catalyzing the reduction of methionine-R-sulfoxides to methionines. This protein is highly expressed in liver and kidney, and is localized to the nucleus and cytosol. It is the only member of the MsrB family that is a selenoprotein, containing a selenocysteine (Sec) residue at its active site. It also has the highest methionine-R-sulfoxide reductase activity compared to other members containing cysteine in place of Sec. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A pseudogene of this locus has been identified on chromosome 19. [provided by RefSeq, Aug 2017]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	20	NC_041773.1 (1964370..1970332, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	20	NC_027912.1 (1923800..1929473, complement)

Chromosome 20 - NC_041773.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables peptide-methionine (R)-S-oxide reductase activity	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: methionine-R-sulfoxide reductase B1

Names: selenoprotein X, 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001346686.2 → NP_001333615.2 methionine-R-sulfoxide reductase B1

Status: REVIEWED

Source sequence(s)

QNVO02000290

UniProtKB/TrEMBL

A0A1D5Q8E9, F7HSX6

Related

ENSMMUP00000010414.4, ENSMMUT00000011106.4

Conserved Domains (1) summary

PRK05550
Location:7 → 114

PRK05550; bifunctional methionine sulfoxide reductase B/A protein; Provisional

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041773.1 Reference Mmul_10 Primary Assembly

Range

1964370..1970332 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001114750.2: Suppressed sequence

Description

NM_001114750.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.