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    SCN1A sodium voltage-gated channel alpha subunit 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 704086, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SCN1Aprovided by VGNC
    Official Full Name
    sodium voltage-gated channel alpha subunit 1provided by VGNC
    Primary source
    VGNC:VGNC:76982
    See related
    Ensembl:ENSMMUG00000008407
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See SCN1A in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 12 NC_041765.1 (53132437..53296293, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 12 NC_027904.1 (52906602..53073318, complement)

    Chromosome 12 - NC_041765.1Genomic Context describing neighboring genes Neighboring gene polypeptide N-acetylgalactosaminyltransferase 3 Neighboring gene uncharacterized LOC114671340 Neighboring gene tetratricopeptide repeat domain 21B Neighboring gene uncharacterized LOC106992602 Neighboring gene sodium voltage-gated channel alpha subunit 9 Neighboring gene L-lactate dehydrogenase B chain pseudogene Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables voltage-gated sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in membrane depolarization during action potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuronal action potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of voltage-gated sodium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sodium channel protein type 1 subunit alpha
    Names
    sodium channel, voltage-gated, type I, alpha subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041765.1 Reference Mmul_10 Primary Assembly

      Range
      53132437..53296293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028830802.1 → XP_028686635.1  sodium channel protein type 1 subunit alpha isoform X5

      UniProtKB/TrEMBL
      G7N878
      Conserved Domains (5) summary
      cd13433
      Location:1456 → 1508
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1189 → 1464
      Ion_trans; Ion transport protein
      pfam06512
      Location:978 → 1185
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:510 → 690
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1780 → 1827
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    2. XM_028830797.1 → XP_028686630.1  sodium channel protein type 1 subunit alpha isoform X3

      UniProtKB/TrEMBL
      G7N878
      Conserved Domains (5) summary
      cd13433
      Location:1473 → 1525
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1206 → 1481
      Ion_trans; Ion transport protein
      pfam06512
      Location:995 → 1202
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:510 → 707
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1797 → 1844
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    3. XM_001101023.4 → XP_001101023.1  sodium channel protein type 1 subunit alpha isoform X1

      See identical proteins and their annotated locations for XP_001101023.1

      UniProtKB/TrEMBL
      A0A1D5QX02, G7N878
      Conserved Domains (5) summary
      cd13433
      Location:1484 → 1536
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1217 → 1492
      Ion_trans; Ion transport protein
      pfam06512
      Location:1006 → 1213
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:510 → 708
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1800 → 1863
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    4. XM_028830800.1 → XP_028686633.1  sodium channel protein type 1 subunit alpha isoform X3

      UniProtKB/TrEMBL
      G7N878
      Conserved Domains (5) summary
      cd13433
      Location:1473 → 1525
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1206 → 1481
      Ion_trans; Ion transport protein
      pfam06512
      Location:995 → 1202
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:510 → 707
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1797 → 1844
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    5. XM_028830801.1 → XP_028686634.1  sodium channel protein type 1 subunit alpha isoform X4

      UniProtKB/TrEMBL
      G7N878
      Conserved Domains (5) summary
      cd13433
      Location:1472 → 1524
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1205 → 1480
      Ion_trans; Ion transport protein
      pfam06512
      Location:994 → 1201
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:509 → 706
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1796 → 1843
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    6. XM_028830803.1 → XP_028686636.1  sodium channel protein type 1 subunit alpha isoform X5

      UniProtKB/TrEMBL
      G7N878
      Conserved Domains (5) summary
      cd13433
      Location:1456 → 1508
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1189 → 1464
      Ion_trans; Ion transport protein
      pfam06512
      Location:978 → 1185
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:510 → 690
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1780 → 1827
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    7. XM_028830798.1 → XP_028686631.1  sodium channel protein type 1 subunit alpha isoform X3

      UniProtKB/TrEMBL
      G7N878
      Conserved Domains (5) summary
      cd13433
      Location:1473 → 1525
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1206 → 1481
      Ion_trans; Ion transport protein
      pfam06512
      Location:995 → 1202
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:510 → 707
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1797 → 1844
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    8. XM_028830795.1 → XP_028686628.1  sodium channel protein type 1 subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A1D5QX02, G7N878
      Related
      ENSMMUP00000052582.1, ENSMMUT00000063716.2
      Conserved Domains (5) summary
      cd13433
      Location:1484 → 1536
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1217 → 1492
      Ion_trans; Ion transport protein
      pfam06512
      Location:1006 → 1213
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:510 → 708
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1800 → 1863
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    9. XM_028830804.1 → XP_028686637.1  sodium channel protein type 1 subunit alpha isoform X6

      UniProtKB/TrEMBL
      G7N878
      Conserved Domains (5) summary
      cd13433
      Location:1455 → 1507
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1188 → 1463
      Ion_trans; Ion transport protein
      pfam06512
      Location:977 → 1184
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:509 → 689
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1779 → 1826
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    10. XM_015110268.2 → XP_014965754.1  sodium channel protein type 1 subunit alpha isoform X4

      UniProtKB/TrEMBL
      G7N878
      Conserved Domains (5) summary
      cd13433
      Location:1472 → 1524
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1205 → 1480
      Ion_trans; Ion transport protein
      pfam06512
      Location:994 → 1201
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:509 → 706
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1796 → 1843
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    11. XM_001100928.4 → XP_001100928.1  sodium channel protein type 1 subunit alpha isoform X5

      See identical proteins and their annotated locations for XP_001100928.1

      UniProtKB/TrEMBL
      G7N878
      Conserved Domains (5) summary
      cd13433
      Location:1456 → 1508
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1189 → 1464
      Ion_trans; Ion transport protein
      pfam06512
      Location:978 → 1185
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:510 → 690
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1780 → 1827
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    12. XM_001101115.4 → XP_001101115.1  sodium channel protein type 1 subunit alpha isoform X3

      See identical proteins and their annotated locations for XP_001101115.1

      UniProtKB/TrEMBL
      G7N878
      Conserved Domains (5) summary
      cd13433
      Location:1473 → 1525
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1206 → 1481
      Ion_trans; Ion transport protein
      pfam06512
      Location:995 → 1202
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:510 → 707
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1797 → 1844
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    13. XM_028830794.1 → XP_028686627.1  sodium channel protein type 1 subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A1D5QX02, G7N878
      Conserved Domains (5) summary
      cd13433
      Location:1484 → 1536
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1217 → 1492
      Ion_trans; Ion transport protein
      pfam06512
      Location:1006 → 1213
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:510 → 708
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1800 → 1863
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    14. XM_028830796.1 → XP_028686629.1  sodium channel protein type 1 subunit alpha isoform X2

      UniProtKB/TrEMBL
      G7N878
      Conserved Domains (5) summary
      cd13433
      Location:1483 → 1535
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1216 → 1491
      Ion_trans; Ion transport protein
      pfam06512
      Location:1005 → 1212
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:509 → 717
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1807 → 1854
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    Nucleotide Protein
    Heading Accession and Version

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