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    EPHA4 EPH receptor A4 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 704857, updated on 17-Aug-2024

    Summary

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    Official Symbol
    EPHA4provided by VGNC
    Official Full Name
    EPH receptor A4provided by VGNC
    Primary source
    VGNC:VGNC:72237
    Locus tag
    EGK_04837
    See related
    Ensembl:ENSMMUG00000012364
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See EPHA4 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 12 NC_041765.1 (108865619..109022125, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 12 NC_027904.1 (103622921..103780103, complement)

    Chromosome 12 - NC_041765.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114671532 Neighboring gene uncharacterized LOC114671429 Neighboring gene 60S ribosomal protein L23-like Neighboring gene uncharacterized LOC114671533

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane-ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ephrin type-A receptor 4
    NP_001247799.1
    XP_028686341.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001260870.1 → NP_001247799.1  ephrin type-A receptor 4 precursor

      See identical proteins and their annotated locations for NP_001247799.1

      Status: PROVISIONAL

      Source sequence(s)
      JU333343
      UniProtKB/TrEMBL
      A0A1D5QL11, A0A8J8XFI3, F7EIX4, G7N911, H9FR39
      Related
      ENSMMUP00000016238.4, ENSMMUT00000017337.4
      Conserved Domains (5) summary
      cd09545
      Location:911 → 981
      SAM_EPH-A4; SAM domain of EPH-A4 subfamily of tyrosine kinase receptors
      cd10482
      Location:30 → 203
      EphR_LBD_A4; Ligand Binding Domain of Ephrin type-A Receptor 4
      cd00063
      Location:441 → 532
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:616 → 882
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam14575
      Location:562 → 618
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041765.1 Reference Mmul_10 Primary Assembly

      Range
      108865619..109022125 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028830508.1 → XP_028686341.1  ephrin type-A receptor 4 isoform X1

      UniProtKB/TrEMBL
      A0A1D5QL11
      Conserved Domains (5) summary
      cd09545
      Location:911 → 981
      SAM_EPH-A4; SAM domain of EPH-A4 subfamily of tyrosine kinase receptors
      cd10482
      Location:30 → 203
      EphR_LBD_A4; Ligand Binding Domain of Ephrin type-A Receptor 4
      cd00063
      Location:441 → 532
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:616 → 882
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam14575
      Location:562 → 616
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    RNA

    1. XR_003721161.1 RNA Sequence

    2. XR_003721162.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials