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    DICER1 dicer 1, ribonuclease III [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 702516, updated on 17-Aug-2024

    Summary

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    Official Symbol
    DICER1provided by VGNC
    Official Full Name
    dicer 1, ribonuclease IIIprovided by VGNC
    Primary source
    VGNC:VGNC:71638
    See related
    Ensembl:ENSMMUG00000023305
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See DICER1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (157272988..157344317, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (157354224..157425528, complement)

    Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L15-like Neighboring gene goosecoid homeobox Neighboring gene microRNA mir-3173 Neighboring gene calmin Neighboring gene uncharacterized LOC106999560

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables deoxyribonuclease I activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ribonuclease III activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic DNA fragmentation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in pre-miRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in siRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RISC complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    endoribonuclease Dicer
    NP_001244801.1
    XP_014999915.1
    XP_014999916.1
    XP_014999917.1
    XP_028706126.1
    XP_028706127.1
    XP_028706128.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001257872.1 → NP_001244801.1  endoribonuclease Dicer

      See identical proteins and their annotated locations for NP_001244801.1

      Status: PROVISIONAL

      Source sequence(s)
      JU333682
      UniProtKB/TrEMBL
      A0A5F7ZPU4, F6SLC3, F7FAP2
      Related
      ENSMMUP00000032603.1, ENSMMUT00000039532.3
      Conserved Domains (7) summary
      smart00535
      Location:1294 → 1385
      RIBOc; Ribonuclease III family
      COG0571
      Location:1664 → 1916
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:886 → 1008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271 → 365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      pfam03368
      Location:630 → 718
      Dicer_dimer; Dicer dimerization domain
      cd18802
      Location:372 → 564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42 → 239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041760.1 Reference Mmul_10 Primary Assembly

      Range
      157272988..157344317 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015144431.2 → XP_014999917.1  endoribonuclease Dicer isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZPU4, F6SLC3, F7FAP2
      Related
      ENSMMUP00000072640.1, ENSMMUT00000106317.1
      Conserved Domains (7) summary
      smart00535
      Location:1294 → 1385
      RIBOc; Ribonuclease III family
      COG0571
      Location:1664 → 1916
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:886 → 1008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271 → 365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      pfam03368
      Location:630 → 718
      Dicer_dimer; Dicer dimerization domain
      cd18802
      Location:372 → 564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42 → 239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

    2. XM_015144429.2 → XP_014999915.1  endoribonuclease Dicer isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZPU4, F6SLC3, F7FAP2
      Conserved Domains (7) summary
      smart00535
      Location:1294 → 1385
      RIBOc; Ribonuclease III family
      COG0571
      Location:1664 → 1916
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:886 → 1008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271 → 365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      pfam03368
      Location:630 → 718
      Dicer_dimer; Dicer dimerization domain
      cd18802
      Location:372 → 564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42 → 239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

    3. XM_028850293.1 → XP_028706126.1  endoribonuclease Dicer isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZPU4, F6SLC3, F7FAP2
      Conserved Domains (7) summary
      smart00535
      Location:1294 → 1385
      RIBOc; Ribonuclease III family
      COG0571
      Location:1664 → 1916
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:886 → 1008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271 → 365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      pfam03368
      Location:630 → 718
      Dicer_dimer; Dicer dimerization domain
      cd18802
      Location:372 → 564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42 → 239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

    4. XM_028850295.1 → XP_028706128.1  endoribonuclease Dicer isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZPU4, F6SLC3, F7FAP2
      Conserved Domains (7) summary
      smart00535
      Location:1294 → 1385
      RIBOc; Ribonuclease III family
      COG0571
      Location:1664 → 1916
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:886 → 1008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271 → 365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      pfam03368
      Location:630 → 718
      Dicer_dimer; Dicer dimerization domain
      cd18802
      Location:372 → 564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42 → 239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

    5. XM_028850294.1 → XP_028706127.1  endoribonuclease Dicer isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZPU4, F6SLC3, F7FAP2
      Conserved Domains (7) summary
      smart00535
      Location:1294 → 1385
      RIBOc; Ribonuclease III family
      COG0571
      Location:1664 → 1916
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:886 → 1008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271 → 365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      pfam03368
      Location:630 → 718
      Dicer_dimer; Dicer dimerization domain
      cd18802
      Location:372 → 564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42 → 239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

    6. XM_015144430.2 → XP_014999916.1  endoribonuclease Dicer isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZPU4, F6SLC3, F7FAP2
      Conserved Domains (7) summary
      smart00535
      Location:1294 → 1385
      RIBOc; Ribonuclease III family
      COG0571
      Location:1664 → 1916
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:886 → 1008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271 → 365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      pfam03368
      Location:630 → 718
      Dicer_dimer; Dicer dimerization domain
      cd18802
      Location:372 → 564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42 → 239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    Nucleotide Protein
    Heading Accession and Version

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