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    LOC703026 S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 703026, updated on 1-Aug-2024

    Summary

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    Gene symbol
    LOC703026
    Gene description
    S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
    See related
    Ensembl:ENSMMUG00000030374
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    TYW1
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    Genomic context

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    See LOC703026 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (52770114..53020076, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (49026977..49277883, complement)

    Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene polypeptide N-acetylgalactosaminyltransferase 17 Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene calneuron 1 Neighboring gene microRNA mir-4650 Neighboring gene transmembrane protein 248 Neighboring gene SBDS ribosome maturation factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in wybutosine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tRNA wybutosine-synthesizing protein 1 homolog; S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
    Names
    tRNA-yW synthesizing protein 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041756.1 Reference Mmul_10 Primary Assembly

      Range
      52770114..53020076 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015133369.2 → XP_014988855.1  S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase isoform X1

      UniProtKB/TrEMBL
      F7EUW4, G7MP27, H9FWN2, I0FT30
      Related
      ENSMMUP00000035344.2, ENSMMUT00000042344.3
      Conserved Domains (4) summary
      cd01335
      Location:412 → 604
      Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
      PRK13762
      Location:351 → 662
      PRK13762; tRNA-modifying enzyme; Provisional
      pfam00258
      Location:81 → 232
      Flavodoxin_1; Flavodoxin
      pfam08608
      Location:594 → 657
      Wyosine_form; Wyosine base formation

    2. XM_028845708.1 → XP_028701541.1  S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase isoform X2

      UniProtKB/TrEMBL
      G7MP27, H9FWN2
      Related
      ENSMMUP00000035342.3, ENSMMUT00000042342.3
      Conserved Domains (2) summary
      PRK13762
      Location:351 → 656
      PRK13762; tRNA-modifying enzyme; Provisional
      pfam00258
      Location:81 → 232
      Flavodoxin_1
    Nucleotide Protein
    Heading Accession and Version

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