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    CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 699460, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CADprovided by VGNC
    Official Full Name
    carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotaseprovided by VGNC
    Primary source
    VGNC:VGNC:106158
    Locus tag
    EGK_05157
    See related
    Ensembl:ENSMMUG00000010269
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See CAD in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 13 NC_041766.1 (81710539..81738749, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 13 NC_027905.1 (27508537..27536243)

    Chromosome 13 - NC_041766.1Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 54 Neighboring gene urocortin Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 gamma Neighboring gene solute carrier family 30 member 3 Neighboring gene all-trans retinoic acid induced differentiation factor Neighboring gene solute carrier family 5 member 6 Neighboring gene transcription factor 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables amino acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables aspartate carbamoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in L-arginine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in glutamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of carbamoyl-phosphate synthase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CAD protein
    XP_014967435.1
    XP_014967437.1
    XP_014967438.1
    XP_014967439.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041766.1 Reference Mmul_10 Primary Assembly

      Range
      81710539..81738749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015111951.2 → XP_014967437.1  CAD protein isoform X2

      UniProtKB/TrEMBL
      H9YY08
      Conserved Domains (13) summary
      cd01744
      Location:178 → 354
      GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
      PRK09060
      Location:1429 → 1810
      PRK09060; dihydroorotase; Validated
      PRK00856
      Location:1920 → 2256
      pyrB; aspartate carbamoyltransferase catalytic subunit; Provisional
      PRK12564
      Location:1 → 355
      PRK12564; carbamoyl phosphate synthase small subunit; Reviewed
      cd01316
      Location:1460 → 1806
      CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
      cd01423
      Location:1313 → 1438
      MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
      TIGR01369
      Location:391 → 1440
      CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
      pfam00185
      Location:2072 → 2253
      OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
      pfam00988
      Location:2 → 138
      CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
      pfam02729
      Location:1925 → 2065
      OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
      pfam02786
      Location:514 → 716
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
      pfam02787
      Location:801 → 921
      CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerization domain
      cl17255
      Location:1048 → 1245
      ATP-grasp_4; ATP-grasp domain

    2. XM_015111952.2 → XP_014967438.1  CAD protein isoform X3

      UniProtKB/TrEMBL
      F6PVP0, H9YY08
      Related
      ENSMMUP00000013443.4, ENSMMUT00000014353.4
      Conserved Domains (13) summary
      cd01744
      Location:178 → 354
      GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
      PRK09060
      Location:1429 → 1810
      PRK09060; dihydroorotase; Validated
      PRK00856
      Location:1937 → 2241
      pyrB; aspartate carbamoyltransferase catalytic subunit; Provisional
      PRK12564
      Location:1 → 355
      PRK12564; carbamoyl phosphate synthase small subunit; Reviewed
      cd01316
      Location:1460 → 1806
      CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
      cd01423
      Location:1313 → 1438
      MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
      TIGR01369
      Location:391 → 1440
      CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
      pfam00185
      Location:2089 → 2238
      OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
      pfam00988
      Location:2 → 138
      CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
      pfam02729
      Location:1942 → 2082
      OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
      pfam02786
      Location:514 → 716
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
      pfam02787
      Location:801 → 921
      CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerization domain
      cl17255
      Location:1048 → 1245
      ATP-grasp_4; ATP-grasp domain

    3. XM_015111949.2 → XP_014967435.1  CAD protein isoform X1

      UniProtKB/TrEMBL
      H9YY08
      Conserved Domains (13) summary
      cd01744
      Location:178 → 354
      GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
      PRK09060
      Location:1429 → 1810
      PRK09060; dihydroorotase; Validated
      PRK00856
      Location:1937 → 2273
      pyrB; aspartate carbamoyltransferase catalytic subunit; Provisional
      PRK12564
      Location:1 → 355
      PRK12564; carbamoyl phosphate synthase small subunit; Reviewed
      cd01316
      Location:1460 → 1806
      CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
      cd01423
      Location:1313 → 1438
      MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
      TIGR01369
      Location:391 → 1440
      CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
      pfam00185
      Location:2089 → 2270
      OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
      pfam00988
      Location:2 → 138
      CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
      pfam02729
      Location:1942 → 2082
      OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
      pfam02786
      Location:514 → 716
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
      pfam02787
      Location:801 → 921
      CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerization domain
      cl17255
      Location:1048 → 1245
      ATP-grasp_4; ATP-grasp domain

    4. XM_015111953.2 → XP_014967439.1  CAD protein isoform X4

      UniProtKB/TrEMBL
      A0A8J8YIH3, G7N9N2, H9YY08, I0FH53
      Related
      ENSMMUP00000055041.1, ENSMMUT00000068715.2
      Conserved Domains (13) summary
      cd01744
      Location:178 → 354
      GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
      PRK09060
      Location:1429 → 1810
      PRK09060; dihydroorotase; Validated
      PRK00856
      Location:1920 → 2224
      pyrB; aspartate carbamoyltransferase catalytic subunit; Provisional
      PRK12564
      Location:1 → 355
      PRK12564; carbamoyl phosphate synthase small subunit; Reviewed
      cd01316
      Location:1460 → 1806
      CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
      cd01423
      Location:1313 → 1438
      MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
      TIGR01369
      Location:391 → 1440
      CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
      pfam00185
      Location:2072 → 2221
      OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
      pfam00988
      Location:2 → 138
      CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
      pfam02729
      Location:1925 → 2065
      OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
      pfam02786
      Location:514 → 716
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
      pfam02787
      Location:801 → 921
      CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerization domain
      cl17255
      Location:1048 → 1245
      ATP-grasp_4; ATP-grasp domain
    Nucleotide Protein
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