U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 699460, updated on 18-Sep-2024

    Summary

    Official Symbol
    CADprovided by VGNC
    Official Full Name
    carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotaseprovided by VGNC
    Primary source
    VGNC:VGNC:106158
    Locus tag
    EGK_05157
    See related
    Ensembl:ENSMMUG00000010269
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CAD in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 13 NC_041766.1 (81710539..81738749, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 13 NC_027905.1 (27508537..27536243)

    Chromosome 13 - NC_041766.1Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 54 Neighboring gene urocortin Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 gamma Neighboring gene solute carrier family 30 member 3 Neighboring gene all-trans retinoic acid induced differentiation factor Neighboring gene solute carrier family 5 member 6 Neighboring gene transcription factor 23

    Genomic regions, transcripts, and products

    General protein information

    Preferred Names
    CAD protein
    XP_014967435.1
    XP_014967437.1
    XP_014967438.1
    XP_014967439.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041766.1 Reference Mmul_10 Primary Assembly

      Range
      81710539..81738749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015111951.2XP_014967437.1  CAD protein isoform X2

      UniProtKB/TrEMBL
      H9YY08
      Conserved Domains (13) summary
      cd01744
      Location:178354
      GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
      PRK09060
      Location:14291810
      PRK09060; dihydroorotase; Validated
      PRK00856
      Location:19202256
      pyrB; aspartate carbamoyltransferase catalytic subunit; Provisional
      PRK12564
      Location:1355
      PRK12564; carbamoyl phosphate synthase small subunit; Reviewed
      cd01316
      Location:14601806
      CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
      cd01423
      Location:13131438
      MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
      TIGR01369
      Location:3911440
      CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
      pfam00185
      Location:20722253
      OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
      pfam00988
      Location:2138
      CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
      pfam02729
      Location:19252065
      OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
      pfam02786
      Location:514716
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
      pfam02787
      Location:801921
      CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerization domain
      cl17255
      Location:10481245
      ATP-grasp_4; ATP-grasp domain
    2. XM_015111952.2XP_014967438.1  CAD protein isoform X3

      UniProtKB/TrEMBL
      F6PVP0, H9YY08
      Related
      ENSMMUP00000013443.4, ENSMMUT00000014353.4
      Conserved Domains (13) summary
      cd01744
      Location:178354
      GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
      PRK09060
      Location:14291810
      PRK09060; dihydroorotase; Validated
      PRK00856
      Location:19372241
      pyrB; aspartate carbamoyltransferase catalytic subunit; Provisional
      PRK12564
      Location:1355
      PRK12564; carbamoyl phosphate synthase small subunit; Reviewed
      cd01316
      Location:14601806
      CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
      cd01423
      Location:13131438
      MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
      TIGR01369
      Location:3911440
      CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
      pfam00185
      Location:20892238
      OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
      pfam00988
      Location:2138
      CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
      pfam02729
      Location:19422082
      OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
      pfam02786
      Location:514716
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
      pfam02787
      Location:801921
      CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerization domain
      cl17255
      Location:10481245
      ATP-grasp_4; ATP-grasp domain
    3. XM_015111949.2XP_014967435.1  CAD protein isoform X1

      UniProtKB/TrEMBL
      H9YY08
      Conserved Domains (13) summary
      cd01744
      Location:178354
      GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
      PRK09060
      Location:14291810
      PRK09060; dihydroorotase; Validated
      PRK00856
      Location:19372273
      pyrB; aspartate carbamoyltransferase catalytic subunit; Provisional
      PRK12564
      Location:1355
      PRK12564; carbamoyl phosphate synthase small subunit; Reviewed
      cd01316
      Location:14601806
      CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
      cd01423
      Location:13131438
      MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
      TIGR01369
      Location:3911440
      CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
      pfam00185
      Location:20892270
      OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
      pfam00988
      Location:2138
      CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
      pfam02729
      Location:19422082
      OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
      pfam02786
      Location:514716
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
      pfam02787
      Location:801921
      CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerization domain
      cl17255
      Location:10481245
      ATP-grasp_4; ATP-grasp domain
    4. XM_015111953.2XP_014967439.1  CAD protein isoform X4

      UniProtKB/TrEMBL
      A0A8J8YIH3, G7N9N2, H9YY08, I0FH53
      Related
      ENSMMUP00000055041.1, ENSMMUT00000068715.2
      Conserved Domains (13) summary
      cd01744
      Location:178354
      GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
      PRK09060
      Location:14291810
      PRK09060; dihydroorotase; Validated
      PRK00856
      Location:19202224
      pyrB; aspartate carbamoyltransferase catalytic subunit; Provisional
      PRK12564
      Location:1355
      PRK12564; carbamoyl phosphate synthase small subunit; Reviewed
      cd01316
      Location:14601806
      CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
      cd01423
      Location:13131438
      MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
      TIGR01369
      Location:3911440
      CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
      pfam00185
      Location:20722221
      OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
      pfam00988
      Location:2138
      CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
      pfam02729
      Location:19252065
      OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
      pfam02786
      Location:514716
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
      pfam02787
      Location:801921
      CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerization domain
      cl17255
      Location:10481245
      ATP-grasp_4; ATP-grasp domain