SPTAN1 spectrin alpha, non-erythrocytic 1 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: SPTAN1provided by VGNC
Official Full Name: spectrin alpha, non-erythrocytic 1provided by VGNC
Primary source: VGNC:VGNC:77869
See related: Ensembl:ENSMMUG00000009327
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 59

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	15	NC_041768.1 (11941174..12027838, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	15	NC_027907.1 (10222314..10308821, complement)

Chromosome 15 - NC_041768.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

SHGC-8025 (e-PCR)
- UniSTS:85777

G28277 (e-PCR)
- UniSTS:14395

RH36410 (e-PCR)
- UniSTS:82245

RH103052 (e-PCR)
- UniSTS:97386

D9S1671E (e-PCR)
- UniSTS:147341

RH12836 (e-PCR)
- UniSTS:26298

D9S183E (e-PCR)
- UniSTS:34291

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables actin filament binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cell junction	IEA Inferred from Electronic Annotation more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info	PubMed
located_in cortical actin cytoskeleton	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: spectrin alpha chain, non-erythrocytic 1

Names: spectrin alpha chain, brain; spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001266024.2 → NP_001252953.1 spectrin alpha chain, non-erythrocytic 1

See identical proteins and their annotated locations for NP_001252953.1

Status: PROVISIONAL

Source sequence(s)

JU476928

UniProtKB/TrEMBL

G7NFS0, H9EN73

Conserved Domains (5) summary

cd11808
Location:971 → 1023

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2332 → 2400

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:679 → 890

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:1663 → 1767

Spectrin; Spectrin repeat

pfam08726
Location:2407 → 2475

EFhand_Ca_insen; Ca2+ insensitive EF hand

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041768.1 Reference Mmul_10 Primary Assembly

Range

11941174..12027838 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015116634.2 → XP_014972120.1 spectrin alpha chain, non-erythrocytic 1 isoform X13

UniProtKB/TrEMBL

H9F6V7

Conserved Domains (5) summary

cd11808
Location:971 → 1023

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2307 → 2375

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:679 → 890

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:1638 → 1742

Spectrin; Spectrin repeat

pfam08726
Location:2382 → 2450

EFhand_Ca_insen; Ca2+ insensitive EF hand
XM_015116629.2 → XP_014972115.1 spectrin alpha chain, non-erythrocytic 1 isoform X8

UniProtKB/TrEMBL

H9F6V7

Conserved Domains (5) summary

cd11808
Location:971 → 1023

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2333 → 2401

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:679 → 890

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:1643 → 1747

Spectrin; Spectrin repeat

pfam08726
Location:2408 → 2476

EFhand_Ca_insen; Ca2+ insensitive EF hand
XM_015116624.2 → XP_014972110.1 spectrin alpha chain, non-erythrocytic 1 isoform X3

UniProtKB/TrEMBL

F7HLP9

Related

ENSMMUP00000012219.4, ENSMMUT00000013037.4

Conserved Domains (5) summary

cd11808
Location:971 → 1023

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2353 → 2421

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:679 → 890

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:1663 → 1767

Spectrin; Spectrin repeat

pfam08726
Location:2428 → 2496

EFhand_Ca_insen; Ca2+ insensitive EF hand
XM_028834421.1 → XP_028690254.1 spectrin alpha chain, non-erythrocytic 1 isoform X12

UniProtKB/TrEMBL

F7HJP9, H9F6V7

Related

ENSMMUP00000012223.4, ENSMMUT00000013041.4

Conserved Domains (5) summary

cd11808
Location:971 → 1023

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2312 → 2380

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:679 → 890

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:1643 → 1747

Spectrin; Spectrin repeat

pfam08726
Location:2387 → 2455

EFhand_Ca_insen; Ca2+ insensitive EF hand
XM_015116633.2 → XP_014972119.1 spectrin alpha chain, non-erythrocytic 1 isoform X11

UniProtKB/TrEMBL

H9F6V7

Conserved Domains (6) summary

cd11808
Location:983 → 1035

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2319 → 2387

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:691 → 902

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:1650 → 1754

Spectrin; Spectrin repeat

pfam08726
Location:2394 → 2462

EFhand_Ca_insen; Ca2+ insensitive EF hand

pfam13499
Location:2322 → 2387

EF-hand_7; EF-hand domain pair
XM_015116632.2 → XP_014972118.1 spectrin alpha chain, non-erythrocytic 1 isoform X10

UniProtKB/TrEMBL

H9F6V7

Conserved Domains (6) summary

cd11808
Location:983 → 1035

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2324 → 2392

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:691 → 902

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:1655 → 1759

Spectrin; Spectrin repeat

pfam08726
Location:2399 → 2467

EFhand_Ca_insen; Ca2+ insensitive EF hand

pfam13499
Location:2327 → 2392

EF-hand_7; EF-hand domain pair
XM_015116625.2 → XP_014972111.1 spectrin alpha chain, non-erythrocytic 1 isoform X4

UniProtKB/TrEMBL

H9F6V7

Conserved Domains (6) summary

cd11808
Location:983 → 1035

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2345 → 2413

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:691 → 902

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:1655 → 1759

Spectrin; Spectrin repeat

pfam08726
Location:2420 → 2488

EFhand_Ca_insen; Ca2+ insensitive EF hand

pfam13499
Location:2348 → 2413

EF-hand_7; EF-hand domain pair
XM_015116627.2 → XP_014972113.1 spectrin alpha chain, non-erythrocytic 1 isoform X6

UniProtKB/TrEMBL

G7NFS0

Conserved Domains (6) summary

cd11808
Location:983 → 1035

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2339 → 2407

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:691 → 902

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:1670 → 1774

Spectrin; Spectrin repeat

pfam08726
Location:2414 → 2482

EFhand_Ca_insen; Ca2+ insensitive EF hand

pfam13499
Location:2342 → 2407

EF-hand_7; EF-hand domain pair
XM_015116623.2 → XP_014972109.1 spectrin alpha chain, non-erythrocytic 1 isoform X2

UniProtKB/TrEMBL

F7HLP9

Conserved Domains (6) summary

cd11808
Location:983 → 1035

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2360 → 2428

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:691 → 902

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:1670 → 1774

Spectrin; Spectrin repeat

pfam08726
Location:2435 → 2503

EFhand_Ca_insen; Ca2+ insensitive EF hand

pfam13499
Location:2363 → 2428

EF-hand_7; EF-hand domain pair
XM_015116628.2 → XP_014972114.1 spectrin alpha chain, non-erythrocytic 1 isoform X7

UniProtKB/TrEMBL

G7NFS0

Related

ENSMMUP00000012218.4, ENSMMUT00000013036.4

Conserved Domains (6) summary

cd11808
Location:983 → 1035

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2338 → 2406

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:691 → 902

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:1675 → 1779

Spectrin; Spectrin repeat

pfam08726
Location:2413 → 2481

EFhand_Ca_insen; Ca2+ insensitive EF hand

pfam13499
Location:2341 → 2406

EF-hand_7; EF-hand domain pair
XM_015116626.2 → XP_014972112.1 spectrin alpha chain, non-erythrocytic 1 isoform X5

UniProtKB/TrEMBL

G7NFS0

Conserved Domains (6) summary

cd11808
Location:983 → 1035

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2344 → 2412

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:691 → 902

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:1675 → 1779

Spectrin; Spectrin repeat

pfam08726
Location:2419 → 2487

EFhand_Ca_insen; Ca2+ insensitive EF hand

pfam13499
Location:2347 → 2412

EF-hand_7; EF-hand domain pair
XM_015116622.2 → XP_014972108.1 spectrin alpha chain, non-erythrocytic 1 isoform X1

UniProtKB/TrEMBL

F7HLP9

Conserved Domains (6) summary

cd11808
Location:983 → 1035

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2365 → 2433

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:691 → 902

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:1675 → 1779

Spectrin; Spectrin repeat

pfam08726
Location:2440 → 2508

EFhand_Ca_insen; Ca2+ insensitive EF hand

pfam13499
Location:2368 → 2433

EF-hand_7; EF-hand domain pair
XM_015116630.2 → XP_014972116.1 spectrin alpha chain, non-erythrocytic 1 isoform X9

UniProtKB/TrEMBL

A0A1D5QJZ8, A0A5K1TXE9, G7NFS0

Related

ENSMMUP00000048371.2, ENSMMUT00000071942.2

Conserved Domains (5) summary

cd11808
Location:971 → 1023

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2327 → 2395

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:679 → 890

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:1658 → 1762

Spectrin; Spectrin repeat

pfam08726
Location:2402 → 2470

EFhand_Ca_insen; Ca2+ insensitive EF hand