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    DEFA1B defensin alpha 1B [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574196, updated on 10-Oct-2024

    Summary

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    Gene symbol
    DEFA1B
    Gene description
    defensin alpha 1B
    See related
    Ensembl:ENSMMUG00000018517
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    MNP1A
    Orthologs
    human all
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    Genomic context

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    See DEFA1B in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 8 NC_041761.1 (7732022..7734526, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 8 NC_027900.1 (7160687..7163194, complement)

    Chromosome 8 - NC_041761.1Genomic Context describing neighboring genes Neighboring gene demidefensin 2 Neighboring gene demidefensin 1 Neighboring gene uncharacterized LOC106999660 Neighboring gene alpha-defensin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation, characterization, cDNA cloning, and antimicrobial properties of two distinct subfamilies of alpha-defensins from rhesus macaque leukocytes. Tang YQ, et al. Infect Immun, 1999 Nov. PMID 10531277, Free PMC Article
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in antibacterial humoral response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in disruption of plasma membrane integrity in another organism IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in innate immune response in mucosa IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neutrophil defensin 1; neutrophil defensin 8
    Names
    Neutrophil defensin 3
    Neutrophil defensin 8
    RMAD-1
    RMAD-3
    RMAD-8
    alpha-defensin 1A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032862.1 → NP_001028034.1  neutrophil defensin 1 precursor

      See identical proteins and their annotated locations for NP_001028034.1

      Status: PROVISIONAL

      Source sequence(s)
      AF184160
      UniProtKB/TrEMBL
      Q9TTZ9, Q9TU00
      Related
      ENSMMUP00000024362.4, ENSMMUT00000026035.4
      Conserved Domains (2) summary
      pfam00323
      Location:68 → 96
      Defensin_1; Mammalian defensin
      pfam00879
      Location:1 → 52
      Defensin_propep; Defensin propeptide

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041761.1 Reference Mmul_10 Primary Assembly

      Range
      7732022..7734526 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015144691.2 → XP_015000177.1  neutrophil defensin 8 isoform X1

      UniProtKB/Swiss-Prot
      P60030, P60032
      Conserved Domains (2) summary
      pfam00323
      Location:68 → 96
      Defensin_1; Mammalian defensin
      pfam00879
      Location:1 → 52
      Defensin_propep; Defensin propeptide
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60030.1 GenPept UniProtKB/Swiss-Prot:P60030
    P60031.1 GenPept UniProtKB/Swiss-Prot:P60031
    P60032.1 GenPept UniProtKB/Swiss-Prot:P60032

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials