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    LOC712294 E3 ubiquitin-protein ligase HERC2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 712294, updated on 9-Nov-2023

    Summary

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    Gene symbol
    LOC712294
    Gene description
    E3 ubiquitin-protein ligase HERC2
    See related
    Ensembl:ENSMMUG00000004370
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    HERC2
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    Genomic context

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    See LOC712294 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    93
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (693715..914275)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (5153930..5376962, complement)

    Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase HERC2 Neighboring gene NIPA magnesium transporter 1 Neighboring gene golgin subfamily A member 6-like protein 7 Neighboring gene uncharacterized LOC114679313 Neighboring gene OCA2 melanosomal transmembrane protein Neighboring gene uncharacterized LOC114679314 Neighboring gene 60S ribosomal protein L5 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase HERC2
    Names
    HECT and RLD domain containing E3 ubiquitin protein ligase 2
    hect domain and RLD 2
    XP_014997211.2
    XP_014997212.2
    XP_014997213.2
    XP_014997214.2
    XP_028706443.1
    XP_028706444.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041760.1 Reference Mmul_10 Primary Assembly

      Range
      693715..914275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015141725.2 → XP_014997211.2  E3 ubiquitin-protein ligase HERC2 isoform X1

      UniProtKB/TrEMBL
      A0A5K1ULJ0, F6V4X1
      Related
      ENSMMUP00000033982.3, ENSMMUT00000040954.3
      Conserved Domains (8) summary
      cd08664
      Location:2765 → 2910
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      COG5184
      Location:2952 → 3322
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4421 → 4792
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:2706 → 2750
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:2460 → 2507
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
      pfam00173
      Location:1211 → 1282
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam06701
      Location:1870 → 1929
      MIB_HERC2; Mib_herc2
      pfam11515
      Location:2554 → 2631
      Cul7; Mouse development and cellular proliferation protein Cullin-7

    2. XM_015141726.2 → XP_014997212.2  E3 ubiquitin-protein ligase HERC2 isoform X2

      UniProtKB/TrEMBL
      H9G1F0
      Related
      ENSMMUP00000033985.3, ENSMMUT00000040957.3
      Conserved Domains (8) summary
      cd08664
      Location:2760 → 2905
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      COG5184
      Location:2947 → 3317
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4416 → 4787
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:2701 → 2745
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:2455 → 2502
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
      pfam00173
      Location:1206 → 1277
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam06701
      Location:1865 → 1924
      MIB_HERC2; Mib_herc2
      pfam11515
      Location:2549 → 2626
      Cul7; Mouse development and cellular proliferation protein Cullin-7

    3. XM_028850611.1 → XP_028706444.1  E3 ubiquitin-protein ligase HERC2 isoform X4

      UniProtKB/TrEMBL
      A0A5K1ULJ0
      Conserved Domains (8) summary
      cd08664
      Location:2580 → 2725
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      COG5184
      Location:2767 → 3137
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4236 → 4607
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:2521 → 2565
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:2275 → 2322
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
      pfam00173
      Location:1026 → 1097
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam06701
      Location:1685 → 1744
      MIB_HERC2; Mib_herc2
      pfam11515
      Location:2369 → 2446
      Cul7; Mouse development and cellular proliferation protein Cullin-7

    4. XM_015141727.2 → XP_014997213.2  E3 ubiquitin-protein ligase HERC2 isoform X5

      UniProtKB/TrEMBL
      A0A5F8AB92
      Conserved Domains (8) summary
      cd08664
      Location:2124 → 2269
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      COG5184
      Location:2311 → 2681
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:3780 → 4151
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:2065 → 2109
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:1819 → 1866
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
      pfam00173
      Location:570 → 641
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam06701
      Location:1229 → 1288
      MIB_HERC2; Mib_herc2
      pfam11515
      Location:1913 → 1990
      Cul7; Mouse development and cellular proliferation protein Cullin-7

    5. XM_028850610.1 → XP_028706443.1  E3 ubiquitin-protein ligase HERC2 isoform X3

      UniProtKB/TrEMBL
      F7FRY8
      Related
      ENSMMUP00000005845.4, ENSMMUT00000006214.4
      Conserved Domains (8) summary
      cd08664
      Location:2590 → 2735
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      COG5184
      Location:2777 → 3147
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4246 → 4617
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:2531 → 2575
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:2285 → 2332
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
      pfam00173
      Location:1036 → 1107
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam06701
      Location:1695 → 1754
      MIB_HERC2; Mib_herc2
      pfam11515
      Location:2379 → 2456
      Cul7; Mouse development and cellular proliferation protein Cullin-7

    6. XM_015141728.2 → XP_014997214.2  E3 ubiquitin-protein ligase HERC2 isoform X6

      UniProtKB/TrEMBL
      F7FRY8
      Conserved Domains (8) summary
      cd08664
      Location:1836 → 1981
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      COG5184
      Location:2023 → 2393
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:3492 → 3863
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:1777 → 1821
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:1531 → 1578
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
      pfam00173
      Location:282 → 353
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam06701
      Location:941 → 1000
      MIB_HERC2; Mib_herc2
      pfam11515
      Location:1625 → 1702
      Cul7; Mouse development and cellular proliferation protein Cullin-7
    Nucleotide Protein
    Heading Accession and Version

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