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    CHRNA7 cholinergic receptor nicotinic alpha 7 subunit [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574230, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CHRNA7provided by VGNC
    Official Full Name
    cholinergic receptor nicotinic alpha 7 subunitprovided by VGNC
    Primary source
    VGNC:VGNC:109119
    See related
    Ensembl:ENSMMUG00000022577
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    nica7
    Orthologs
    human all
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    Genomic context

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    See CHRNA7 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (6122838..6267790, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (7904212..8048782)

    Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene golgin subfamily A member 2 pseudogene Neighboring gene golgin subfamily A member 8S Neighboring gene putative uncharacterized protein DKFZp434L187 Neighboring gene ribosomal protein L3-like Neighboring gene small nucleolar RNA SNORA18 Neighboring gene OTU deubiquitinase 7A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex. Yang Y, et al. Proc Natl Acad Sci U S A, 2013 Jul 16. PMID 23818597, Free PMC Article
    2. The ly-6 protein, lynx1, is an endogenous inhibitor of nicotinic signaling in airway epithelium. Fu XW, et al. Am J Physiol Lung Cell Mol Physiol, 2012 Oct 15. PMID 22923641, Free PMC Article
    3. Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells. Proskocil BJ, et al. Endocrinology, 2004 May. PMID 14764638
    4. Nicotine activates and up-regulates nicotinic acetylcholine receptors in bronchial epithelial cells. Fu XW, et al. Am J Respir Cell Mol Biol, 2009 Jul. PMID 19097990, Free PMC Article
    5. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nicotinic alpha7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex.
      Title: Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex.
    2. Lynx1 appears to act as a negative modulator of alpha7 nAChR-induced events by inhibiting Src activation.
      Title: The ly-6 protein, lynx1, is an endogenous inhibitor of nicotinic signaling in airway epithelium.
    3. Chronic nicotine exposure up-regulates nAChR activity in developing lung, and that nAChR activity can be further modified by tyrosine phosphorylation.
      Title: Nicotine activates and up-regulates nicotinic acetylcholine receptors in bronchial epithelial cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables acetylcholine-gated monoatomic cation-selective channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neuronal acetylcholine receptor subunit alpha-7
    Names
    cholinergic receptor, nicotinic, alpha 7 (neuronal)
    nicotinic acetylcholine receptor alpha7
    nicotinic acetylcholine receptor subunit alpha7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032883.1 → NP_001028055.1  neuronal acetylcholine receptor subunit alpha-7 precursor

      See identical proteins and their annotated locations for NP_001028055.1

      Status: PROVISIONAL

      Source sequence(s)
      AF486623
      UniProtKB/Swiss-Prot
      Q866A2
      UniProtKB/TrEMBL
      G7MW91
      Related
      ENSMMUP00000029721.4, ENSMMUT00000031766.4
      Conserved Domains (3) summary
      TIGR00860
      Location:3 → 490
      LIC; Cation transporter family protein
      pfam02931
      Location:26 → 230
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:237 → 486
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041760.1 Reference Mmul_10 Primary Assembly

      Range
      6122838..6267790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001445798.2 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q866A2.1 GenPept UniProtKB/Swiss-Prot:Q866A2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.