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    TLN1 talin 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 696298, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TLN1provided by VGNC
    Official Full Name
    talin 1provided by VGNC
    Primary source
    VGNC:VGNC:78371
    Locus tag
    EGK_07566
    See related
    Ensembl:ENSMMUG00000031856
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    talin-1
    Orthologs
    human mouse all
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    Genomic context

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    See TLN1 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    60
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 15 NC_041768.1 (48471238..48506252)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 15 NC_027907.1 (48525484..48560512)

    Chromosome 15 - NC_041768.1Genomic Context describing neighboring genes Neighboring gene glucosylceramidase beta 2 Neighboring gene uncharacterized LOC106993704 Neighboring gene cAMP responsive element binding protein 3 Neighboring gene tropomyosin 2 Neighboring gene Rho guanine nucleotide exchange factor 39 Neighboring gene carbonic anhydrase 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in platelet aggregation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    talin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041768.1 Reference Mmul_10 Primary Assembly

      Range
      48471238..48506252
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015117466.2 → XP_014972952.1  talin-1 isoform X4

      UniProtKB/TrEMBL
      A0A5F7ZMX7, A0A8J8XDX9, F7HL22, G7NFD2
      Related
      ENSMMUP00000066972.1, ENSMMUT00000105821.1
      Conserved Domains (10) summary
      cd12150
      Location:1654 → 1826
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:88 → 313
      B41; Band 4.1 homologues
      smart00307
      Location:2336 → 2532
      ILWEQ; I/LWEQ domain
      cd10569
      Location:309 → 400
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:204 → 313
      FERM_M; FERM central domain
      pfam08913
      Location:1849 → 1973
      VBS; Vinculin Binding Site
      pfam09141
      Location:491 → 652
      Talin_middle; Talin, middle domain
      pfam09379
      Location:90 → 186
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:4 → 83
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:607 → 759
      I_LWEQ; I/LWEQ domain

    2. XM_015117462.2 → XP_014972948.1  talin-1 isoform X1

      UniProtKB/TrEMBL
      F7HL22
      Conserved Domains (9) summary
      cd12150
      Location:1671 → 1843
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:88 → 313
      B41; Band 4.1 homologues
      smart00307
      Location:2354 → 2550
      ILWEQ; I/LWEQ domain
      cd10569
      Location:309 → 400
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:1866 → 1990
      VBS; Vinculin Binding Site
      cd17171
      Location:2 → 85
      FERM_F0_TLN1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-1 (TLN1)
      cd17173
      Location:86 → 197
      FERM_F1_TLN1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-1 (TLN1)
      pfam09141
      Location:491 → 652
      Talin_middle; Talin, middle domain
      cl19756
      Location:839 → 935
      I_LWEQ; I/LWEQ domain

    3. XM_015117463.2 → XP_014972949.1  talin-1 isoform X1

      UniProtKB/TrEMBL
      F7HL22
      Conserved Domains (9) summary
      cd12150
      Location:1671 → 1843
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:88 → 313
      B41; Band 4.1 homologues
      smart00307
      Location:2354 → 2550
      ILWEQ; I/LWEQ domain
      cd10569
      Location:309 → 400
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:1866 → 1990
      VBS; Vinculin Binding Site
      cd17171
      Location:2 → 85
      FERM_F0_TLN1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-1 (TLN1)
      cd17173
      Location:86 → 197
      FERM_F1_TLN1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-1 (TLN1)
      pfam09141
      Location:491 → 652
      Talin_middle; Talin, middle domain
      cl19756
      Location:839 → 935
      I_LWEQ; I/LWEQ domain

    4. XM_028835069.1 → XP_028690902.1  talin-1 isoform X2

      UniProtKB/TrEMBL
      A0A1D5REJ7, F7HL22
      Related
      ENSMMUP00000058740.2, ENSMMUT00000054208.2
      Conserved Domains (9) summary
      cd12150
      Location:1671 → 1843
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:88 → 313
      B41; Band 4.1 homologues
      smart00307
      Location:2353 → 2549
      ILWEQ; I/LWEQ domain
      cd10569
      Location:309 → 400
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:1866 → 1990
      VBS; Vinculin Binding Site
      pfam09141
      Location:491 → 652
      Talin_middle; Talin, middle domain
      cd17171
      Location:2 → 85
      FERM_F0_TLN1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-1 (TLN1)
      cd17173
      Location:86 → 197
      FERM_F1_TLN1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-1 (TLN1)
      cl19756
      Location:839 → 929
      I_LWEQ; I/LWEQ domain

    5. XM_028835068.1 → XP_028690901.1  talin-1 isoform X1

      UniProtKB/TrEMBL
      F7HL22
      Conserved Domains (9) summary
      cd12150
      Location:1671 → 1843
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:88 → 313
      B41; Band 4.1 homologues
      smart00307
      Location:2354 → 2550
      ILWEQ; I/LWEQ domain
      cd10569
      Location:309 → 400
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:1866 → 1990
      VBS; Vinculin Binding Site
      cd17171
      Location:2 → 85
      FERM_F0_TLN1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-1 (TLN1)
      cd17173
      Location:86 → 197
      FERM_F1_TLN1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-1 (TLN1)
      pfam09141
      Location:491 → 652
      Talin_middle; Talin, middle domain
      cl19756
      Location:839 → 935
      I_LWEQ; I/LWEQ domain

    6. XM_028835070.1 → XP_028690903.1  talin-1 isoform X3

      UniProtKB/TrEMBL
      F7HL22
      Related
      ENSMMUP00000039464.3, ENSMMUT00000046424.3
      Conserved Domains (9) summary
      cd12150
      Location:1654 → 1826
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:88 → 313
      B41; Band 4.1 homologues
      smart00307
      Location:2337 → 2533
      ILWEQ; I/LWEQ domain
      cd10569
      Location:309 → 400
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:1849 → 1973
      VBS; Vinculin Binding Site
      cd17171
      Location:2 → 85
      FERM_F0_TLN1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-1 (TLN1)
      cd17173
      Location:86 → 197
      FERM_F1_TLN1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-1 (TLN1)
      pfam09141
      Location:491 → 652
      Talin_middle; Talin, middle domain
      cl19756
      Location:607 → 759
      I_LWEQ; I/LWEQ domain

    7. XM_028835071.1 → XP_028690904.1  talin-1 isoform X5

      UniProtKB/TrEMBL
      F7HL22
      Conserved Domains (7) summary
      cd12150
      Location:1383 → 1555
      talin-RS; rod-segment of the talin C-terminal domain
      smart00307
      Location:2066 → 2262
      ILWEQ; I/LWEQ domain
      cd10569
      Location:21 → 112
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:1578 → 1702
      VBS; Vinculin Binding Site
      pfam09141
      Location:203 → 364
      Talin_middle; Talin, middle domain
      cl09511
      Location:1 → 25
      FERM_B-lobe; FERM domain B-lobe
      cl19756
      Location:551 → 647
      I_LWEQ; I/LWEQ domain
    Nucleotide Protein
    Heading Accession and Version

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