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    APC2 APC regulator of WNT signaling pathway 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 707345, updated on 17-Aug-2024

    Summary

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    Official Symbol
    APC2provided by VGNC
    Official Full Name
    APC regulator of WNT signaling pathway 2provided by VGNC
    Primary source
    VGNC:VGNC:69888
    See related
    Ensembl:ENSMMUG00000003053
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See APC2 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (1239016..1266638)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 19 NC_027911.1 (1247697..1275272)

    Chromosome 19 - NC_041772.1Genomic Context describing neighboring genes Neighboring gene DAZ associated protein 1 Neighboring gene ribosomal protein S15 Neighboring gene chromosome 19 C19orf25 homolog Neighboring gene proprotein convertase subtilisin/kexin type 4 Neighboring gene receptor accessory protein 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables gamma-catenin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell fate specification IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of microtubule depolymerization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in pattern specification process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of beta-catenin destruction complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of catenin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasmic microtubule IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenomatous polyposis coli protein 2
    Names
    APC2, WNT signaling pathway regulator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041772.1 Reference Mmul_10 Primary Assembly

      Range
      1239016..1266638
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015122353.2 → XP_014977839.1  adenomatous polyposis coli protein 2 isoform X2

      UniProtKB/TrEMBL
      I2CYF3
      Conserved Domains (8) summary
      cd00020
      Location:600 → 718
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:1284 → 1305
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:1650 → 1667
      SAMP; SAMP Motif
      pfam05956
      Location:1810 → 2134
      APC_basic; APC basic domain
      pfam11414
      Location:148 → 229
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:721 → 968
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16689
      Location:30 → 81
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      sd00043
      Location:551 → 584
      ARM; armadillo repeat [structural motif]

    2. XM_015122354.2 → XP_014977840.1  adenomatous polyposis coli protein 2 isoform X3

      UniProtKB/TrEMBL
      F6VET0, I2CYF3
      Related
      ENSMMUP00000004073.4, ENSMMUT00000004321.4
      Conserved Domains (8) summary
      cd00020
      Location:599 → 717
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:1283 → 1304
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:1649 → 1666
      SAMP; SAMP Motif
      pfam05956
      Location:1809 → 2133
      APC_basic; APC basic domain
      pfam11414
      Location:148 → 228
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:720 → 967
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16689
      Location:30 → 81
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      sd00043
      Location:550 → 583
      ARM; armadillo repeat [structural motif]

    3. XM_015122352.2 → XP_014977838.2  adenomatous polyposis coli protein 2 isoform X1

      UniProtKB/TrEMBL
      I2CYF3
      Conserved Domains (11) summary
      smart00185
      Location:697 → 737
      ARM; Armadillo/beta-catenin-like repeats
      PHA03247
      Location:1597 → 2051
      PHA03247; large tegument protein UL36; Provisional
      PRK07764
      Location:2131 → 2380
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      PRK12323
      Location:1432 → 1658
      PRK12323; DNA polymerase III subunits gamma and tau; Provisional
      pfam16689
      Location:89 → 140
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      sd00043
      Location:610 → 643
      ARM; armadillo repeat [structural motif]
      pfam05956
      Location:1869 → 2196
      APC_basic; APC basic domain
      pfam10473
      Location:65 → 169
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam11414
      Location:207 → 288
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:780 → 1027
      Arm_APC_u3; Armadillo-associated region on APC
      pfam05923
      Location:1343 → 1364
      APC_r; APC repeat
    Nucleotide Protein
    Heading Accession and Version

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