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    RGS12 regulator of G protein signaling 12 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 699927, updated on 17-Aug-2024

    Summary

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    Official Symbol
    RGS12provided by VGNC
    Official Full Name
    regulator of G protein signaling 12provided by VGNC
    Primary source
    VGNC:VGNC:100266
    See related
    Ensembl:ENSMMUG00000007154
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See RGS12 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 5 NC_041758.1 (3406839..3562316)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 5 NC_027897.1 (3588577..3729967)

    Chromosome 5 - NC_041758.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene huntingtin Neighboring gene Myb/SANT DNA binding domain containing 1 Neighboring gene HGF activator Neighboring gene docking protein 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regulator of G-protein signaling 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041758.1 Reference Mmul_10 Primary Assembly

      Range
      3406839..3562316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028848273.1 → XP_028704106.1  regulator of G-protein signaling 12 isoform X1

      UniProtKB/TrEMBL
      A0A1D5QJ26, G7MFT0
      Related
      ENSMMUP00000048048.2, ENSMMUT00000057558.2
      Conserved Domains (9) summary
      cd08742
      Location:716 → 830
      RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
      smart00390
      Location:1188 → 1209
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      cd00992
      Location:20 → 96
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13162
      Location:228 → 359
      PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
      pfam16611
      Location:1106 → 1176
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16612
      Location:1254 → 1374
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:836 → 949
      RGS12_us1; Unstructured region of RGS12
      cd17136
      Location:962 → 1031
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      cd17138
      Location:1032 → 1104
      RBD2_RGS12; Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12)

    2. XM_015137901.2 → XP_014993387.1  regulator of G-protein signaling 12 isoform X2

      UniProtKB/TrEMBL
      H9Z399
      Conserved Domains (7) summary
      smart00455
      Location:1035 → 1104
      RBD; Raf-like Ras-binding domain
      cd01817
      Location:963 → 1035
      RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
      cd08742
      Location:716 → 830
      RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
      cd00992
      Location:20 → 96
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13162
      Location:228 → 359
      PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
      pfam16611
      Location:1106 → 1137
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16613
      Location:836 → 933
      RGS12_us1; Unstructured region of RGS12

    3. XM_015137903.2 → XP_014993389.2  regulator of G-protein signaling 12 isoform X4

      UniProtKB/TrEMBL
      H9EZ84
      Conserved Domains (7) summary
      cd08742
      Location:68 → 182
      RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
      smart00390
      Location:540 → 561
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam16611
      Location:458 → 528
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16612
      Location:606 → 726
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:188 → 301
      RGS12_us1; Unstructured region of RGS12
      cd17136
      Location:314 → 383
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      cl28922
      Location:384 → 456
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    4. XM_015137902.2 → XP_014993388.2  regulator of G-protein signaling 12 isoform X3

      UniProtKB/TrEMBL
      H9EZ84
      Conserved Domains (7) summary
      cd08742
      Location:71 → 185
      RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
      smart00390
      Location:543 → 564
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam16611
      Location:461 → 531
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16612
      Location:609 → 729
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:191 → 304
      RGS12_us1; Unstructured region of RGS12
      cd17136
      Location:317 → 386
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      cl28922
      Location:387 → 459
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    Nucleotide Protein
    Heading Accession and Version

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