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    LRP5 LDL receptor related protein 5 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 721605, updated on 17-Aug-2024

    Summary

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    Official Symbol
    LRP5provided by VGNC
    Official Full Name
    LDL receptor related protein 5provided by VGNC
    Primary source
    VGNC:VGNC:101301
    See related
    Ensembl:ENSMMUG00000031237
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See LRP5 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 14 NC_041767.1 (6323377..6464987, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 14 NC_027906.1 (6181373..6285459, complement)

    Chromosome 14 - NC_041767.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 6 regulatory subunit 3 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC114672220 Neighboring gene uncharacterized LOC106993178 Neighboring gene chromosome 14 C11orf24 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables Wnt receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables Wnt-protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    low-density lipoprotein receptor-related protein 5
    Names
    low density lipoprotein receptor-related protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041767.1 Reference Mmul_10 Primary Assembly

      Range
      6323377..6464987 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028833138.1 → XP_028688971.1  low-density lipoprotein receptor-related protein 5 isoform X1

      Conserved Domains (7) summary
      smart00135
      Location:405 → 447
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00112
      Location:1346 → 1380
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:717 → 753
      NHL; NHL repeat [structural motif]
      pfam00058
      Location:160 → 200
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      cl18310
      Location:682 → 875
      NHL; NHL repeat unit of beta-propeller proteins
      pfam00057
      Location:1268 → 1305
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam14670
      Location:296 → 333
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    2. XM_028833139.1 → XP_028688972.1  low-density lipoprotein receptor-related protein 5 isoform X2

      UniProtKB/TrEMBL
      F7CJV4
      Related
      ENSMMUP00000037689.3, ENSMMUT00000044668.3
      Conserved Domains (7) summary
      smart00135
      Location:405 → 447
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00112
      Location:1333 → 1367
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:717 → 753
      NHL; NHL repeat [structural motif]
      pfam00058
      Location:160 → 200
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      cl18310
      Location:682 → 875
      NHL; NHL repeat unit of beta-propeller proteins
      pfam00057
      Location:1255 → 1292
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam14670
      Location:296 → 333
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    Nucleotide Protein
    Heading Accession and Version

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