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    PDE10A phosphodiesterase 10A [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 714983, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PDE10Aprovided by VGNC
    Official Full Name
    phosphodiesterase 10Aprovided by VGNC
    Primary source
    VGNC:VGNC:75908
    See related
    Ensembl:ENSMMUG00000023614
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PDE10A in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (4739016..5415945)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 4 NC_027896.1 (166516725..166795430, complement)

    Chromosome 4 - NC_041757.1Genomic Context describing neighboring genes Neighboring gene mitochondrial import receptor subunit TOM6 homolog pseudogene Neighboring gene uncharacterized LOC114677372 Neighboring gene putative uncharacterized protein FLJ36797 Neighboring gene putative transcriptional regulator encoded by LINC00473 Neighboring gene uncharacterized LOC106998194 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC106998130 Neighboring gene chromosome 4 C6orf118 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of cGMP-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
    XP_001105004.2
    XP_014993138.1
    XP_014993139.1
    XP_014993141.1
    XP_028702818.1
    XP_028702819.1
    XP_028702820.1
    XP_028702821.1
    XP_028702822.1
    XP_028702823.1
    XP_028702824.1
    XP_028702825.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041757.1 Reference Mmul_10 Primary Assembly

      Range
      4739016..5415945
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028846987.1 → XP_028702820.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X3

      UniProtKB/TrEMBL
      F7HBA5, G7MR66
      Related
      ENSMMUP00000031087.4, ENSMMUT00000033220.4
      Conserved Domains (3) summary
      smart00065
      Location:294 → 449
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:541 → 773
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam01590
      Location:118 → 261
      GAF; GAF domain

    2. XM_028846991.1 → XP_028702824.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X7

      UniProtKB/TrEMBL
      A0A5F7ZVN1
      Conserved Domains (3) summary
      smart00065
      Location:197 → 352
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:444 → 676
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam01590
      Location:21 → 164
      GAF; GAF domain

    3. XM_028846986.1 → XP_028702819.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X2

      UniProtKB/TrEMBL
      G7MR66
      Conserved Domains (3) summary
      smart00065
      Location:335 → 490
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:582 → 814
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam01590
      Location:159 → 302
      GAF; GAF domain

    4. XM_028846988.1 → XP_028702821.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X3

      UniProtKB/TrEMBL
      F7HBA5, G7MR66
      Conserved Domains (3) summary
      smart00065
      Location:294 → 449
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:541 → 773
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam01590
      Location:118 → 261
      GAF; GAF domain

    5. XM_028846985.1 → XP_028702818.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1

      UniProtKB/TrEMBL
      G7MR66
      Conserved Domains (3) summary
      smart00065
      Location:370 → 525
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:617 → 849
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam01590
      Location:194 → 337
      GAF; GAF domain

    6. XM_028846989.1 → XP_028702822.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X4

      UniProtKB/TrEMBL
      G7MR66
      Conserved Domains (3) summary
      smart00065
      Location:267 → 422
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:514 → 746
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam01590
      Location:91 → 234
      GAF; GAF domain

    7. XM_028846990.1 → XP_028702823.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X5

      UniProtKB/TrEMBL
      A0A5F8AUT3
      Related
      ENSMMUP00000080756.1, ENSMMUT00000102153.1
      Conserved Domains (3) summary
      smart00065
      Location:277 → 432
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:524 → 756
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam01590
      Location:101 → 244
      GAF; GAF domain

    8. XM_015137652.2 → XP_014993138.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X4

      UniProtKB/TrEMBL
      G7MR66
      Conserved Domains (3) summary
      smart00065
      Location:267 → 422
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:514 → 746
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam01590
      Location:91 → 234
      GAF; GAF domain

    9. XM_015137655.2 → XP_014993141.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X6

      UniProtKB/TrEMBL
      A0A1D5Q6B3, G7MR66
      Related
      ENSMMUP00000043579.1, ENSMMUT00000071718.2
      Conserved Domains (3) summary
      smart00065
      Location:260 → 415
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:507 → 739
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam01590
      Location:84 → 227
      GAF; GAF domain

    10. XM_015137653.2 → XP_014993139.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X4

      UniProtKB/TrEMBL
      G7MR66
      Conserved Domains (3) summary
      smart00065
      Location:267 → 422
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:514 → 746
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam01590
      Location:91 → 234
      GAF; GAF domain

    11. XM_028846992.1 → XP_028702825.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X7

      UniProtKB/TrEMBL
      A0A5F7ZVN1
      Conserved Domains (3) summary
      smart00065
      Location:197 → 352
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:444 → 676
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam01590
      Location:21 → 164
      GAF; GAF domain

    12. XM_001105004.4 → XP_001105004.2  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X7

      UniProtKB/TrEMBL
      A0A5F7ZVN1
      Related
      ENSMMUP00000069714.1, ENSMMUT00000104862.1
      Conserved Domains (3) summary
      smart00065
      Location:197 → 352
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:444 → 676
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam01590
      Location:21 → 164
      GAF; GAF domain
    Nucleotide Protein
    Heading Accession and Version

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